Protein Alignment ARRDC3 and CG3014

DIOPT Version :10

• Sequence 1: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_649738.1
• Gene: CG3014 / 40922
• FlyBaseID: FBgn0037519
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 105/412 - (25%)
• Similarity: 172/412 - (41%)
• Gaps: 83/412 - (20%)

Human    14 DCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEE 78
            |.||    |||:||:.:|||:.|......||.::.:...|.|||:|  |.:..|.||   ||:..
  Fly    10 DRLN----PVYNSGEYISGRILLRTDKVKRVNAVYVTLEGEAKVQW--SMSGKSETA---NYSGH 65

Human    79 VEYFNHKDILIGHERDD--DNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAE 141
            .:|.        |.|.:  ||:     ...:|.|.|..:..:|....:|. :|.:|.:.|.:...
  Fly    66 QQYL--------HSRTNVFDNT-----LFRAGVHVYVLTLRIPPDCPSTC-KGPYGYIAYTISLT 116

Human   142 LHRPWLLPVKLKKEFTVFEHIDINTPSLLS-PQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPG 205
            :.:||......:|...|.:.:|:|..:..| |......|.||.|.|.||||..:..:...|:||.
  Fly   117 IDKPWGFDEVFRKPIIVVQTLDLNYNAEFSLPVKDENLKYLCHWPCISGPICSTLTLPASGFTPL 181

Human   206 ESIQIFAEIENCSSR--MVVPKAAIYQTQAFYAKGKMKE-------VKQLVANLRGESLSSGKTE 261
            :.:....|::|.|..  ::..:.:|.|...|.::..:|.       ||:|::: |...||..:.|
  Fly   182 QEVPYRLEVDNQSPHYDIIGVEVSIKQHFVFLSRKPVKRNFYSKTLVKELISD-RTLRLSKRQYE 245

Human   262 TWNGKLLKIPPVSP-SILDCS-IIRVEYSLMV-----YVDIPGAMDLFLNLPLVIGTIPLHPFGS 319
            :    .:.:|..:| |.|:.: |:.:.|:|.|     |..    .|..|::|:::||..|...
  Fly   246 S----SICVPMDTPRSTLNPNYIVFLHYTLQVKLKTGYFH----YDTDLSVPIIVGTTSLQHL-- 300

Human   320 RTSSVSSQCSMNMNWLSLSLPERPE-------APPSYAEVVTEEQRRNNLAPVSACDDFERALQG 377
             ..||.:|..:...    ..|||..       .||:     .||.......|  |.|:..|.::.
  Fly   301 -RDSVHTQQPVRRT----PTPERQRLIERVTPRPPT-----VEEDSAGEADP--ATDEPHRVIED 353

Human   378 PLFAYIQEFRFLPPPLYSEIDP 399
            .           .||.|....|
  Fly   354 D-----------EPPSYDSCLP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:425619	40/144 (28%)
		Arrestin_C	187..314	CDD:214976	35/142 (25%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		2/7 (29%)
CG3014	NP_649738.1	Arrestin_N	5..140	CDD:451447	43/152 (28%)
		Arrestin_C	164..294	CDD:214976	33/138 (24%)