Protein Alignment ARRDC3 and CG2641

DIOPT Version :10

• Sequence 1: NP_065852.1
• Gene: ARRDC3 / 57561
• HGNCID: 29263
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_649737.1
• Gene: CG2641 / 40921
• FlyBaseID: FBgn0037518
• Length: 429
• Species: Drosophila melanogaster
• Alignment Length: 444
• Identity: 126/444 - (28%)
• Similarity: 180/444 - (40%)
• Gaps: 83/444 - (18%)

Human    12 SFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYT 76
            ||:.  |...|:|.||:||:||..|..|.|..|..:.|...|.|||||.| |...:....|::||
  Fly     6 SFEL--DRREPIYYSGETVNGRAILTTTSEKSVNEVYILFEGEAKVRWDE-RRTRTRGGKTEHYT 67

Human    77 EEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELP-QTPLATSFEGRHGSVRYWVKA 140
               |||..|...: :.|   .|..|...:..|.|.|.|...|| :.|  :|...::|.:.|.|..
  Fly    68 ---EYFRGKQQYL-YTR---TSVFGSGNLPPGTHTYNFCIPLPLECP--SSVVAQYGKIFYEVSV 123

Human   141 ELHRPWLLPVKLKKEFTVFEHIDIN-TPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTP 204
            .:.|.|......|:..||.:..::| :|.||.|......|..|||.|:|||:..:..|...||.|
  Fly   124 VIDRQWRFNNVFKQPLTVIQTYNLNMSPQLLMPLVREDIKHFCCWPCSSGPVLSTLTIPFGGYAP 188

Human   205 GESIQIFAEIENCSS-------RMVVPKAAIYQTQAFYAKGKMKE--VKQLVANLRGESLSSGKT 260
            |:.|:...||:|.||       .:.:.:...:|.|..:.|.:.||  :.:.....|...||..|.
  Fly   189 GQKIRFTLEIDNQSSGYDLNGIELKLKQIYKFQAQTPHHKTREKEHSLNKSCQQERVLRLSKKKI 253

Human   261 ETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA-MDLFLNLPLVIGTIPLHPFGSRTSSV 324
            |    ..|.||.|.||.....||.|.|.:::.:..... :|....:|:|||||||.......:|.
  Fly   254 E----GTLAIPAVPPSSRTEGIISVSYQVILTISTGDCHVDSDFEVPIVIGTIPLIQSAENPASA 314

Human   325 SSQCSMNMNWLSLSLPERPEA--------PPSY------------------AEVVTEEQRRNNLA 363
            :       .|    :||.|:.        ||||                  .::..:|..|.
  Fly   315 A-------QW----IPETPDTPAGAAADLPPSYDKCKPPTFEEATNFGERFIDIDQDEHNRT--- 365

Human   364 PVSACDDFERALQGPLFAYIQEFRF-----LPPPLYSEIDPNPDQSADDRPSCP 412
                 |||.     |.:.....|..     .||..::...|.|..|....|:.|
  Fly   366 -----DDFI-----PRYPMYTNFAMPSAPPQPPEEFATNQPVPVLSLPHDPTAP 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:425619	47/143 (33%)
		Arrestin_C	187..314	CDD:214976	41/136 (30%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..414		5/20 (25%)
CG2641	NP_649737.1	Arrestin_N	5..148	CDD:425619	50/153 (33%)
		Arrestin_C	171..304	CDD:460676	41/136 (30%)