DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TAOK1 and MCK1

DIOPT Version :9

Sequence 1:	NP_065842.1	Gene:	TAOK1 / 57551	HGNCID:	29259	Length:	1001	Species:	Homo sapiens
Sequence 2:	NP_014092.1	Gene:	MCK1 / 855409	SGDID:	S000005251	Length:	375	Species:	Saccharomyces cerevisiae

Alignment Length:	322	Identity:	82/322 - (25%)
Similarity:	132/322 - (40%)	Gaps:	97/322 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    27 LFTDLREIGHGSFGAV---YFARDVRTNEV--VAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHP 86
            |..:.|:||.|:||.|   |..:| :.|.:  .||||:....:..:       :|::.|:...||
Yeast    34 LVKEYRKIGRGAFGTVVQAYLTQD-KKNWLGPFAIKKVPAHTEYKS-------RELQILRIADHP 90

Human    87 NSIEYKGCYLREHTA--------WLVMEYCLGSASDLLEVHK-------KPLQEVEIAAITHGAL 136
            |.::.:  |...|.:        .|.|| ||..... :|:::       .||:.:.:  .|:...
Yeast    91 NIVKLQ--YFFTHLSPQDNKVYQHLAME-CLPETLQ-IEINRYVTNKLEMPLKHIRL--YTYQIA 149

Human   137 QGLAYLHSHTMIHRDIKAGNILL-TEPGQVKLADFGSASMA---SPANSFVGTPYWMAPEVILAM 197
            :|:.|||...:.|||||..|:|: .|.|.:|:.|||||...   .|:.|::.:.::.|||:|:..
Yeast   150 RGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGC 214

Human   198 DEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSD---------- 252
            .  ||..::|:|.||  |:           |..|.....|.|.:.|.||..|.:.
Yeast   215 T--QYTTQIDIWGLG--CV-----------MGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFI 264

Human   253 YFRN------------FVDSCLQKI----------------------PQDRPTSEELLKHIF 280
            :|.|            |..|..|:.                      ||.|.:...:|.|.|
Yeast   265 FFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQF 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAOK1	NP_065842.1	STKc_TAO1	2..318	CDD:270805	82/322 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..433
		SbcC	<442..>877	CDD:223496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1001
MCK1	NP_014092.1	STKc_GSK3	39..330	CDD:271039	81/317 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910