Protein Alignment TAOK1 and SKM1

DIOPT Version :10

• Sequence 1: NP_065842.1
• Gene: TAOK1 / 57551
• HGNCID: 29259
• Length: 1001
• Species: Homo sapiens
• Sequence 2: NP_014528.1
• Gene: SKM1 / 854036
• SGDID: S000005473
• Length: 655
• Species: Saccharomyces cerevisiae
• Alignment Length: 304
• Identity: 105/304 - (34%)
• Similarity: 155/304 - (50%)
• Gaps: 39/304 - (12%)

Human    23 DPEKLFTDLREIGHGSFGAVYFARDVR-----------------TNEVVAIKKMSYSGKQSTEKW 70
            :|...|..:.:.|.|:.||||.::.::                 ..|.||||::..|   ...|.
Yeast   355 NPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLS---EQPKK 416

Human    71 QDIIKEVKFLQRIKHPNSIEYKGCY-LREHTAWLVMEYCLGSA-SDLLEV--------HKKPLQE 125
            |.|:.|:..:...:..|.:.:...| :.:...|::|||..|.. :|:|:.        |..||.|
Yeast   417 QLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNE 481

Human   126 VEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTP 186
            .::|.|.....|||.:||:..:||||||:.||||...|.||:.|||    .....|...:.||||
Yeast   482 NQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTP 546

Human   187 YWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNE-W 250
            ||||||::   ::..||.|||||||||..||:.|.:||..|.:.:.|||.||.|.||.|:..| .
Yeast   547 YWMAPEIV---NQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESV 608

Human   251 SDYFRNFVDSCLQKIPQDRPTSEELLKHIFV-LRERPETVLIDL 293
            |...:.|:|:|||...:.|.:..:||...|: :...||.:.:.|
Yeast   609 SKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVSL 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TAOK1	NP_065842.1	STKc_TAO1	2..318	CDD:270805	105/304 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..433
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..587
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..1001
SKM1	NP_014528.1	PH_Cla4_Ste20	4..113	CDD:270097
		PBD	122..180	CDD:395634
		STKc_PAK	359..640	CDD:270789	101/286 (35%)