DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGSF9 and DIP-delta

DIOPT Version :9

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_001097508.2 Gene:DIP-delta / 5740816 FlyBaseID:FBgn0085420 Length:469 Species:Drosophila melanogaster


Alignment Length:438 Identity:99/438 - (22%)
Similarity:169/438 - (38%) Gaps:77/438 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYS--PRIDPDYVGRVR 86
            |.|...|||...   |.|.:....|    :.:.|:.....:.:.|...:.|  ||....|.....
  Fly    51 PNVTVAVGRDAN---LPCVVEHLGG----YKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTW 108

Human    87 LQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWV-----HLTVNSPPQFQ--ETPPA 144
            |     |.:.....:|:|:|.|:|             |.:.:     :|.|..||...  |:.|:
  Fly   109 L-----LHVNQAHQDDRGYYMCQV-------------NTNPMISQVGYLQVVVPPNILDIESTPS 155

Human   145 VLEVQELEPVTLRCVARGSPLPHVTWKLR-GKDLG-QGQGQVQVQNG-TLRIRRVERGSSGVYTC 206
            .:.|:|.:.:.:.|.|.|.|.|.:.|:.. |:::. :.:.:|.|.:. .|.:.:|.|...|.|.|
  Fly   156 SVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLC 220

Human   207 QASSTEGSATHATQLLVLG---PPVIVVPPKNSTVNA--SQDVSLACHAEAYPANLTYSWFQDNI 266
            .|  |.|.....::.::|.   .|:|.||  |..|.|  ..||::.||.||:|..:.| |..:::
  Fly   221 IA--TNGVPPSVSKRIILDVEFSPMIWVP--NQLVGAPSGTDVTIDCHTEAHPKAIIY-WVYNSV 280

Human   267 NVFHISRLQPRVRILVDGS---------LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYP 322
            .|.      |..:...|.:         |.:...|..|.|.|.|:..|.|.....:.....:..|
  Fly   281 MVL------PSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLP 339

Human   323 AQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPG-WSQGTEGSLIIALGN 386
            :..:.....|.:......:|  |...|.....:. |..|.|::.|.:|| .|..:.|....|..:
  Fly   340 STPSKQVTHTTVESRENNII--PSSRNDTTKSLQ-TDVGYAMKNDLYPGSASSSSSGGSSSAASS 401

Human   387 EDAL------GEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEY 428
            ..::      |..:....:|:|:.|...:.:...     :.|||..||
  Fly   402 SSSMQTSALPGGVAGNSLSSMGSKGSLAIGKSTF-----YTERPPNEY 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 Ig 24..132 CDD:299845 23/114 (20%)
IG_like 28..110 CDD:214653 18/83 (22%)
I-set 136..223 CDD:254352 23/91 (25%)
Ig 154..220 CDD:143165 18/68 (26%)
Ig_3 226..305 CDD:290638 25/89 (28%)
IG_like 233..319 CDD:214653 23/96 (24%)
Ig 341..404 CDD:299845 15/69 (22%)
IG_like 431..503 CDD:214653
Ig 436..500 CDD:143165
fn3 511..596 CDD:278470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626
FN3 625..715 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
DIP-deltaNP_001097508.2 IG 51..143 CDD:214652 24/116 (21%)
Ig 145..238 CDD:416386 24/94 (26%)
Ig strand A 145..149 CDD:409353 1/3 (33%)
Ig strand A' 154..159 CDD:409353 1/4 (25%)
Ig strand B 165..172 CDD:409353 1/6 (17%)
Ig strand C 178..183 CDD:409353 1/4 (25%)
Ig strand C' 185..187 CDD:409353 0/1 (0%)
Ig strand D 195..199 CDD:409353 1/3 (33%)
Ig strand E 203..209 CDD:409353 1/5 (20%)
Ig strand F 216..223 CDD:409353 4/8 (50%)
Ig strand G 230..238 CDD:409353 1/7 (14%)
Ig 242..333 CDD:416386 27/99 (27%)
Ig strand A' 250..253 CDD:409353 1/2 (50%)
Ig strand B 259..266 CDD:409353 3/6 (50%)
Ig strand C 272..277 CDD:409353 2/5 (40%)
Ig strand C' 281..283 CDD:409353 0/1 (0%)
Ig strand D 289..293 CDD:409353 1/3 (33%)
Ig strand E 295..305 CDD:409353 1/9 (11%)
Ig strand F 314..322 CDD:409353 3/7 (43%)
Ig strand G 325..334 CDD:409353 0/8 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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