DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and dpr12

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	76/312 - (24%)
Similarity:	121/312 - (38%)	Gaps:	68/312 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    43 LLPP----AGRPPLHVIEWLRFGFL-LPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVED 102
            ::||    ..|.|||::| ||...| ||..    |.:..::||       ||..        :.|
  Fly     3 MVPPRLLLRLRRPLHLME-LRILLLCLPTL----LLATTLEPD-------QKSI--------LTD 47

Human   103 QGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAV--LEVQELEPVTLRCVARGSPL 165
            ..|   :..::...|..|...:.   :|..:..|.|:::....  ..||......|.|...|...
  Fly    48 NDW---KKLWMRGGINGDSKLDN---NLDSSDSPMFEDSELMAHNTTVQLGGTAFLVCKVSGVDR 106

Human   166 PHVTWK----LRGKD---LGQGQGQVQVQN-------------GTLRIRRVERGSSGVYTCQASS 210
            ..|.|.    :|.:|   |..| .|:...:             .||:|:.|:|...|:|.||.|:
  Fly   107 VGVNWNQISWIRRRDWHILSSG-AQLYTNDERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVST 170

Human   211 TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQ 275
            ..|..:|...|.|:.|...::......|:....::|.|..|..|....|.::|.|..:  |:.:.
  Fly   171 PTGIISHFVNLQVVVPEAFILGSGELHVDMGSTINLVCIIEKSPTPPQYVYWQKNDRL--INYVD 233

Human   276 PRVRILVDGS------LRLLATQPD--DAGCYTCVPSNGLLHPPSASAYLTV 319
            .|..|.::.:      .||:..:|.  |:|.|||..||    ...||.|:.|
  Fly   234 SRRDITIETTPGPRTQSRLIIREPQVTDSGNYTCSASN----TEPASIYVFV 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	22/93 (24%)
		IG_like	28..110	CDD:214653	19/71 (27%)
		I-set	136..223	CDD:254352	27/108 (25%)
		Ig	154..220	CDD:143165	22/85 (26%)
		Ig_3	226..305	CDD:290638	20/86 (23%)
		IG_like	233..319	CDD:214653	24/93 (26%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr12	NP_652462.3	IG	86..183	CDD:214652	25/97 (26%)
		Ig_3	193..271	CDD:404760	19/79 (24%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	1/3 (33%)
		Ig strand E	250..254	CDD:409353	2/3 (67%)
		Ig strand F	264..269	CDD:409353	3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810