DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and DIP-gamma

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	92/362 - (25%)
Similarity:	134/362 - (37%)	Gaps:	105/362 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    24 PEVVSVVGR----AGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGR 84
            ||.:..:..    ||...:|.|. :...|:   :.:.|||......:.:|             ||
  Fly    39 PEFIGFINNVTYPAGREAILACS-VRNLGK---NKVGWLRASDQTVLALQ-------------GR 86

Human    85 VRLQKGA-----------SLQIEGLRVEDQGWYEC---------RVFFLDQHIPEDDFANGSWVH 129
            |......           .|:|..||..|:|.|.|         :|..:|..:|.|
  Fly    87 VVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINTSPMKKQVGCIDVQVPPD--------- 142

Human   130 LTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWK-------LRGKDLGQGQGQVQVQ 187
             .:|      |...|.|.|||.|..||.|.|.|:|.|.|||:       |..|...:...:|:..
  Fly   143 -IIN------EESSADLAVQEGEDATLTCKATGNPQPRVTWRREDGEMILIRKPGSRELMKVESY 200

Human   188 NG-TLRIRRVERGSSGVYTCQASS-TEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHA 250
            || :||:.|:||...|.|.|.||: ...:.:....|.|...|::..|.:........||.|.|..
  Fly   201 NGSSLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTPLGSDVQLECQV 265

Human   251 EAYPANLTYSWFQD--------NINVFHISRLQPRVRILVDG-------------SLRLLATQ-- 292
            ||.|:.::| |.:.        :::...:....|...:|:||             .:.||..:
  Fly   266 EASPSPVSY-WLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVMLLVVRSF 329

Human   293 -PDDAGCYTCVPSNGL-------------LHPPSASA 315
             |.|.|.|.||.:|.|             || |.|||
  Fly   330 SPSDVGTYHCVSTNSLGRAEGTLRLYEIKLH-PGASA 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	26/131 (20%)
		IG_like	28..110	CDD:214653	20/105 (19%)
		I-set	136..223	CDD:254352	33/95 (35%)
		Ig	154..220	CDD:143165	25/74 (34%)
		Ig_3	226..305	CDD:290638	23/102 (23%)
		IG_like	233..319	CDD:214653	29/120 (24%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	22/108 (20%)
		Ig	47..129	CDD:299845	20/98 (20%)
		Ig	140..238	CDD:299845	36/113 (32%)
		IG_like	247..355	CDD:214653	24/108 (22%)
		Ig	256..351	CDD:299845	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810