DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and dpr17

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	63/282 - (22%)
Similarity:	102/282 - (36%)	Gaps:	86/282 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    17 GADGRGKP-------EVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRF--GFLLPI----FI 68
            |.||.|..       .|:::..:.|....:.|.:...:.:|    :.|:|.  ..::.:    ||
  Fly   396 GGDGAGSAVRRNLTMPVLNITAQMGNHAYMPCQIHRLSDKP----VSWVRMRDNHIISVDETTFI 456

Human    69 ---QF-GLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVH 129
               :| .:|..  |.||..        ||||:.:...|.|||||      |...|...:  :.||
  Fly   457 ADERFQSIYQE--DHDYTW--------SLQIKYVEPSDAGWYEC------QMATEPKLS--AKVH 503

Human   130 LTVNSP--------PQFQETPPAVLEVQELEPVTLRCVARGS--PLPHVTW-----KLRGKD--- 176
            |.:..|        .:|         |:....|.|.|:.||:  |..::.|     |:...|
  Fly   504 LQIVKPKTELIGDQSRF---------VKAGSKVALHCIVRGTLDPPKYIIWFRGQKKISDSDERT 559

Human   177 -------------LGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPV 228
                         :|..|..:    |:|.|..|.:..||.||||.|:   |.:.:..|.||....
  Fly   560 GWYTQLDRNIFGTVGDNQNTI----GSLIIPLVRKEDSGNYTCQPSN---SVSVSVDLHVLSGEY 617

Human   229 IVVPPKNSTVNASQDVSLACHA 250
            ......::....::.....||:
  Fly   618 SASAIMSTAARTTKGGRSTCHS 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	28/124 (23%)
		IG_like	28..110	CDD:214653	22/91 (24%)
		I-set	136..223	CDD:254352	26/109 (24%)
		Ig	154..220	CDD:143165	23/88 (26%)
		Ig_3	226..305	CDD:290638	2/25 (8%)
		IG_like	233..319	CDD:214653	2/18 (11%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	22/96 (23%)
		Ig	415..507	CDD:299845	27/113 (24%)
		IG_like	521..612	CDD:214653	25/97 (26%)
		IGc2	524..605	CDD:197706	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810