DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9 and dpr5

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	163	Identity:	44/163 - (26%)
Similarity:	74/163 - (45%)	Gaps:	16/163 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   191 LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPA 255
            |:|..|::..:|||.||. |||...:.|.:|:|:.....::..:...:.:..|::|.|.|...|.
  Fly   159 LKIVSVQQRDAGVYECQV-STEPKISLAYKLVVVTSKAQILANRELFIQSGSDINLTCIAPQAPG 222

Human   256 NLTYS-WFQDNINVFHISRLQPRV---RILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAY 316
            ..|:. |.:|...|...:|...||   :.:...:|.:...|..|:|.|||...|.    .|.|.:
  Fly   223 PYTHMLWHKDTELVSDSARGGIRVESEQQMKTSNLVISRVQHTDSGNYTCSADNS----NSDSVF 283

Human   317 LTVLYPAQVTAMPPE-------TPLPIGMPGVI 342
            :.::...|..||..|       .|||:.:..|:
  Fly   284 VHIIKSEQHAAMQHELGSRLLLPPLPLLLLAVL 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	13/31 (42%)
		Ig	154..220	CDD:143165	12/28 (43%)
		Ig_3	226..305	CDD:290638	19/82 (23%)
		IG_like	233..319	CDD:214653	22/89 (25%)
		Ig	341..404	CDD:299845	1/2 (50%)
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr5	NP_650080.3	V-set	95..191	CDD:284989	13/32 (41%)
		IG_like	98..179	CDD:214653	9/20 (45%)
		IG_like	206..278	CDD:214653	20/75 (27%)
		Ig	211..278	CDD:143165	19/70 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810