DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9 and dpr20

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	58/266 - (21%)
Similarity:	95/266 - (35%)	Gaps:	89/266 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    25 EVVSVVGRAGESVVLGC--DLLPPAGRPPLHVIEWLRF---------GFLLPIFIQFGLYSPRID 78
            :..::..:||.|:.|.|  .||..      ..:.|:|.         |..|.: :..|:::...|
  Fly   275 QATNLTVQAGSSIHLNCRISLLQD------KTVSWVRHNTQDEGKDNGNALDL-LTVGMHTYTGD 332

Human    79 PDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPP 143
            ..|....:......|:|..::.:|:..|||::   ..|.|     ....::|.||:        |
  Fly   333 KRYKMEFQYPNNWRLKITNVKKDDEAIYECQI---STHPP-----RVIQINLHVNA--------P 381

Human   144 AVLEVQEL-EP-----------VTLRCVARGSPLPH--VTWK----LRGKDLGQGQGQVQVQ--- 187
            .|:.|.|: :|           :.|.||.|...:..  |.||    :...|:.:|...|:.:
  Fly   382 KVMIVDEVGDPLQEKYYEIDSTLQLSCVVRNVAMTSSVVFWKHMDNILNYDVTRGGVSVKTELME 446

Human   188 ---NGTLRIRRVERGSSGVYTCQASSTE-------------------GSAT------------HA 218
               |.||.|.::.:..||.|||..|..:                   |.|.            ||
  Fly   447 DGANSTLSIAKISKTDSGNYTCSISEFQNFTIVVHILNGESFAELHHGGAVGWHSTWWNMVMLHA 511

Human   219 TQLLVL 224
            ..||||
  Fly   512 MALLVL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	23/117 (20%)
		IG_like	28..110	CDD:214653	20/92 (22%)
		I-set	136..223	CDD:254352	30/141 (21%)
		Ig	154..220	CDD:143165	24/108 (22%)
		Ig_3	226..305	CDD:290638
		IG_like	233..319	CDD:214653
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	20/96 (21%)
		Ig	279..378	CDD:299845	23/113 (20%)
		Ig	400..471	CDD:299845	19/70 (27%)
		IG_like	402..480	CDD:214653	20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810