DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGSF9 and robo1

DIOPT Version :10

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster


Alignment Length:1380 Identity:301/1380 - (21%)
Similarity:443/1380 - (32%) Gaps:400/1380 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     2 VWCL-GLAVLSLVISQGADG-RGK---PEVV----SVVGRAGESVVLGCDLLPPAGRPPLHVIEW 57
            :|.| ...:|.||.|.|... ||:   |.::    .:|.:..|...|.|.:   .|:|. ..|||
  Fly    29 MWLLPAWLLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKV---EGKPE-PTIEW 89

Human    58 LRFGFLLPIFIQFGLYSPRIDPDYVG-----RVRLQKGASL---QIEGLRVEDQGWYEC------ 108
            .:.|                :|....     ||:.:.||..   .::|.:.:|.|.|.|      
  Fly    90 FKDG----------------EPVSTNEKKSHRVQFKDGALFFYRTMQGKKEQDGGEYWCVAKNRV 138

Human   109 -----RVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRC-VARGSPLPH 167
                 |...|...:..|||                 ...|....|.:.|...|.| ..:|.|.|.
  Fly   139 GQAVSRHASLQIAVLRDDF-----------------RVEPKDTRVAKGETALLECGPPKGIPEPT 186

Human   168 VTW--------KLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHA-TQLLV 223
            :.|        .|:....|.......|..|.|.|..||....|.|.|.|.:..|:...: .:|:|
  Fly   187 LIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESSYAKLIV 251

Human   224 LGPPVIVVPPKNSTVNASQDVSLACHAEA-YPANLTYSWFQDNINVFHISRLQPRVRILVD-GSL 286
            ...|..:..||:..:...|..:..|.... .|..:.:...:.||.|       .|.|||.| .||
  Fly   252 QVKPYFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPV-------SRARILHDEKSL 309

Human   287 RLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRAN-- 349
            .:....|.|.|.|.|...|. :...||.|.|.|..|...|..|...  .:|:.||::.|..|:  
  Fly   310 EISNITPTDEGTYVCEAHNN-VGQISARASLIVHAPPNFTKRPSNK--KVGLNGVVQLPCMASGN 371

Human   350 -PPLLFVSWTKDGKALQLDKFPGWSQG-----TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSP 408
             ||.:|  |||:|.:..:  ||..|.|     .:|:|.|....::..|.|.|:.::.:    .|.
  Fly   372 PPPSVF--WTKEGVSTLM--FPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFSVV----DSS 428

Human   409 VTRVLLKA------PPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQ--GQAQV 465
            ..||.|:.      ||..|:..........|....:||.|.|:|.|.:.|...|..:|  .:..:
  Fly   429 TVRVFLQVSSLDERPPPIIQIGPANQTLPKGSVATLPCRATGNPSPRIKWFHDGHAVQAGNRYSI 493

Human   466 DSNSSLILRPLTKEAHGHWECSAS---NAVARVATSTNVYVLGTSPHVVTNVSVVALPKGA---- 523
            ...|||.:..|.....|.:.|:||   ...:..||.|......||.|...:.|....|.|.    
  Fly   494 IQGSSLRVDDLQLSDSGTYTCTASGERGETSWAATLTVEKPGSTSLHRAADPSTYPAPPGTPKVL 558

Human   524 NVS-------W-----EPGFDG---GY-LQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVP 572
            |||       |     :||..|   || ::.||         || :...|:..|..||...:.:.
  Fly   559 NVSRTSISLRWAKSQEKPGAVGPIIGYTVEYFS---------PD-LQTGWIVAAQRVGDTQVTIS 613

Human   573 GLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPR 637
            ||.|.|.|.|.|.|:|..|        :|.|.||..|     :...|.....:....|.|.||  
  Fly   614 GLTPGTSYVFLVRAENTQG--------ISVPSGLSNT-----IKTIEADFDAASANDLSAART-- 663

Human   638 GVLLHWDPPELV---------------------PKRLDGYVLEGRQGS------QGWEVLDPAVA 675
              ||.....||:                     .|.::|..:..:..|      ....|:|   |
  Fly   664 --LLTGKSVELIDASAINASAVRLEWMLHVSADEKYVEGLRIHYKDASVPSAQYHSITVMD---A 723

Human   676 GTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSR----------TQLPGL 730
            ..|: .:|..|.|...|||.|..|..:....|||:....|  .|..||.          .|..|.
  Fly   724 SAES-FVVGNLKKYTKYEFFLTPFFETIEGQPSNSKTALT--YEDVPSAPPDNIQIGMYNQTAGW 785

Human   731 L---PQP--------------VLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQ--- 775
            :   |.|              |.||....|  |....|.:.....|||..........||..   
  Fly   786 VRWTPPPSQHHNGNLYGYKIEVSAGNTMKV--LANMTLNATTTSVLLNNLTTGAVYSVRLNSFTK 848

Human   776 --DPP------LIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPD 832
              |.|      |...||.....|.|..||:.|.    :.:|       |.|.:.:....|....:
  Fly   849 AGDGPYSKPISLFMDPTHHVHPPRAHPSGTHDG----RHEG-------QDLTYHNNGNIPPGDIN 902

Human   833 PPSSR-------GPLPLEPIC-------------------------------------------R 847
            |.:.:       ||..:..:|                                           .
  Fly   903 PTTHKKTTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSDNEITALNIN 967

Human   848 GPDGRFV---MGPTVAAPQERSGREQAE---------------------PRTPAQRLARSFDCSS 888
            ..:..::   .|...|...:.||..:::                     .....:.|...::|..
  Fly   968 SKESLWIDHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNNSDGGTDYAEVDTRNLTTFYNCRK 1032

Human   889 SSPSGAP-----------QPLCIEDISPVAPPPAAPPSP----LPGPGPLL-----QYLSLPFFR 933
            |..:..|           ...|.:..|..|...:...||    ..|..|.:     .||..| ..
  Fly  1033 SPDNPTPYATTMIIGTSSSETCTKTTSISADKDSGTHSPYSDAFAGQVPAVPVVKSNYLQYP-VE 1096

Human   934 EMNVDGDW-----PPLEEPSPAAPPDYMDTRRCPTSSFLRSPET-PPVSPRESLPGAVVGAG--- 989
            .:|    |     ||.|.|.|::...|  .:..|.||...|... ..:|..:|:..|.:.:.   
  Fly  1097 PIN----WSEFLPPPPEHPPPSSTYGY--AQGSPESSRKSSKSAGSGISTNQSILNASIHSSSSG 1155

Human   990 -----------ATAEP-------PYTALADWTL-RERLLP------------------GLLP--- 1014
                       |.|.|       |.:|:|..|. |.::.|                  |.:|   
  Fly  1156 GFSAWGVSPQYAVACPPENVYSNPLSAVAGGTQNRYQITPTNQHPPQLPAYFATTGPGGAVPPNH 1220

Human  1015 ---AAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSK 1076
               |..|.:.:...:|..:|...:  |.|.::..:..:|:|.........||.|.:..|..:...
  Fly  1221 LPFATQRHAASEYQAGLNAARCAQ--SRACNSCDALATPSPMQPPPPVPVPEGWYQPVHPNSHPM 1283

Human  1077 RRNTSVDENYEWDSE 1091
            ...:|..:.|:..||
  Fly  1284 HPTSSNHQIYQCSSE 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653 20/100 (20%)
Ig strand B 37..41 CDD:409353 1/3 (33%)
Ig strand C 54..58 CDD:409353 2/3 (67%)
Ig strand E 91..95 CDD:409353 1/6 (17%)
Ig 136..223 CDD:472250 23/96 (24%)
Ig strand B 154..158 CDD:409353 1/3 (33%)
Ig strand C 167..171 CDD:409353 1/11 (9%)
Ig strand E 189..193 CDD:409353 2/3 (67%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig_3 226..305 CDD:464046 21/80 (26%)
Ig <341..404 CDD:472250 20/70 (29%)
Ig strand B 341..344 CDD:409353 1/2 (50%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 2/3 (67%)
Ig strand F 392..397 CDD:409353 2/4 (50%)
Ig 418..503 CDD:472250 23/89 (26%)
Ig strand B 436..440 CDD:409570 0/3 (0%)
Ig strand C 449..453 CDD:409570 0/3 (0%)
Ig strand E 469..473 CDD:409570 3/3 (100%)
FN3 482..>717 CDD:442628 73/284 (26%)
Ig strand F 483..488 CDD:409570 1/4 (25%)
Ig strand G 496..499 CDD:409570 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 3/19 (16%)
FN3 625..715 CDD:238020 26/116 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919 33/251 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988 14/53 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079 12/63 (19%)
PDZ-binding. /evidence=ECO:0000250 1177..1179
robo1NP_476899.1 Ig 56..151 CDD:472250 23/114 (20%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 2/3 (67%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 23/92 (25%)
Ig strand A 158..161 CDD:409389 0/2 (0%)
Ig strand A' 163..167 CDD:409389 0/3 (0%)
Ig strand B 171..178 CDD:409389 2/6 (33%)
Ig strand C 186..191 CDD:409389 1/4 (25%)
Ig strand C' 193..196 CDD:409389 0/2 (0%)
Ig strand D 209..213 CDD:409389 0/3 (0%)
Ig strand E 216..222 CDD:409389 3/5 (60%)
Ig strand F 229..237 CDD:409389 4/7 (57%)
Ig strand G 240..251 CDD:409389 2/10 (20%)
IgI_3_Robo 258..341 CDD:409390 25/90 (28%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 2/8 (25%)
Ig strand C 285..290 CDD:409390 0/4 (0%)
Ig strand C' 293..296 CDD:409390 1/2 (50%)
Ig strand D 299..304 CDD:409390 3/4 (75%)
Ig strand E 305..313 CDD:409390 3/7 (43%)
Ig strand F 320..328 CDD:409390 3/7 (43%)
Ig strand G 331..341 CDD:409390 4/9 (44%)
Ig 346..437 CDD:472250 28/100 (28%)
Ig strand B 362..366 CDD:409353 0/3 (0%)
Ig strand C 375..379 CDD:409353 1/5 (20%)
Ig strand E 402..406 CDD:409353 2/3 (67%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 21/84 (25%)
Ig strand B 462..466 CDD:409544 0/3 (0%)
Ig strand C 475..479 CDD:409544 0/3 (0%)
Ig strand E 497..501 CDD:409544 3/3 (100%)
FN3 507..>916 CDD:442628 106/454 (23%)
Ig strand F 511..516 CDD:409544 1/4 (25%)
Ig strand G 524..527 CDD:409544 0/2 (0%)
FN3 549..637 CDD:238020 30/105 (29%)
fn3 770..855 CDD:394996 17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

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