DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and Dscam1

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	803	Identity:	186/803 - (23%)
Similarity:	283/803 - (35%)	Gaps:	223/803 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    28 SVVGRAGESVV-----LGCDLLPPA-----GRP----------PLHVIEWLRFGFLLPIFIQFGL 72
            ||.|.:.|:|:     |...:.||.     |||          |:..:.|::.|..:      |.
  Fly   331 SVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAI------GH 389

Human    73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN---S 134
            ..|                .|:||.::.||:|.|:|       .:..|..:..:...|.:.   .
  Fly   390 SEP----------------VLRIESVKKEDKGMYQC-------FVRNDQESAEASAELKLGGRFD 431

Human   135 PP----QFQETPPAVLEVQELEP---VTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQN 188
            ||    .|||        :.:||   |.|:|||.|:|.|.::|:|.||.:....    ||....|
  Fly   432 PPVIRQAFQE--------ETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVN 488

Human   189 GT----LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH 249
            |.    |.|..|.....|:|.|.|.|..|.|.|:.:|.|.|.|.|....|.:.| |.:.:.:.|.
  Fly   489 GDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIV-AGETLIVTCP 552

Human   250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGLLHPPSA 313
            ...||.: :..|.:|| ....|:|.|   ::..:|:|.:...:.: |...||||..|...:....
  Fly   553 VAGYPID-SIVWERDN-RALPINRKQ---KVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARG 612

Human   314 SAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ---- 374
            |..:.|:...|:.....|..:.:|....:.|.::.....:.|.|:.:..|...    |:.|
  Fly   613 SLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDY----GFDQVQPQ 673

Human   375 ------GTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
                  ..:.|:| |...:....|..:|...|..||...|  ..:.:..||.:|..|.::.|.:
  Fly   674 MRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYS--VDLTVNVPPRWILEPTDKAFAQ- 735

Human   433 GRELLIPCSAQGDPPPVVSWTK-VG---------------RGLQGQAQVDSNSSLILRPLTKEAH 481
            |.:..:.|.|.|.|.|.|:|.| ||               |..:|...||:        :.|...
  Fly   736 GSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDN--------IQKTNE 792

Human   482 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-----------------------KGA 523
            |::.|.|.|.:            |:....|..:||.|.|                       ||.
  Fly   793 GYYLCEAINGI------------GSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGE 845

Human   524 ----------NVSWEPGFDGGYLQRFSVWYTPL-----AKRPDRMHHDWVSLAVPVGAAHLLVPG 573
                      |:..:|..|..|..|..:..|.:     .||.:|
  Fly   846 KPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTER--------------------- 889

Human   574 LQPHTQYQFSVLAQNKLGS--GPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 636
               .....|:.:|.|..||  ...:.||...|               |:|..|.     |..::.
  Fly   890 ---SDSALFTCVATNAFGSDDASINMIVQEVP---------------EMPYALK-----VLDKSG 931

Human   637 RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPA-VAGTETELLVPGLIKDVLYEFRLVAFA 700
            |.|.|.|..|......||.|::|.::....|..:|.. |.|..||..|..|.....|..|:||..
  Fly   932 RSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAEN 996

Human   701 GSFVSDPSNTANVSTSGLEVYPS 723
            ....|..|....:.|:  |..||
  Fly   997 AIGTSQSSEAVTIITA--EEAPS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	26/123 (21%)
		IG_like	28..110	CDD:214653	24/101 (24%)
		I-set	136..223	CDD:254352	34/101 (34%)
		Ig	154..220	CDD:143165	27/73 (37%)
		Ig_3	226..305	CDD:290638	21/79 (27%)
		IG_like	233..319	CDD:214653	21/86 (24%)
		Ig	341..404	CDD:299845	13/73 (18%)
		IG_like	431..503	CDD:214653	20/87 (23%)
		Ig	436..500	CDD:143165	19/79 (24%)
		fn3	511..596	CDD:278470	21/124 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		3/19 (16%)
		FN3	625..715	CDD:238020	24/90 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	5/11 (45%)
		Ig	269..340	CDD:143165	4/8 (50%)
		IG_like	353..425	CDD:214653	19/100 (19%)
		IGc2	361..413	CDD:197706	16/80 (20%)
		I-set	433..527	CDD:254352	34/101 (34%)
		IGc2	446..517	CDD:197706	25/70 (36%)
		I-set	533..618	CDD:254352	22/90 (24%)
		IGc2	544..607	CDD:197706	17/67 (25%)
		Ig	641..714	CDD:143165	15/78 (19%)
		IGc2	735..804	CDD:197706	20/89 (22%)
		I-set	819..914	CDD:254352	17/118 (14%)
		Ig	833..921	CDD:299845	20/126 (16%)
		FN3	918..1011	CDD:238020	28/112 (25%)
		FN3	1018..1116	CDD:238020	186/803 (23%)
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810