DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and bdl

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	842	Identity:	216/842 - (25%)
Similarity:	317/842 - (37%)	Gaps:	204/842 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAVLSLV----ISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIF 67
            ||:|:::    ||..:..|......::..:.|..||..|.:..|...|..:::.|.:....:
  Fly    17 LALLAIILLMNISCTSAARDHRRQTNLEAKVGSHVVFNCYIDFPFDAPIPYLVHWTKDNKKI--- 78

Human    68 IQFGLYSPRIDPD--YVGRVRLQKG------ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFAN 124
              |..|.......  :.||:.|.:.      ||:.:..:|..|||||.|:|          .|.|
  Fly    79 --FTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQV----------SFPN 131

Human   125 GSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNG 189
            .|                |:|.                                        .||
  Fly   132 RS----------------PSVR----------------------------------------NNG 140

Human   190 TLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYP 254
            |                           |..|.|.|..:|.:||.|.|:...|.....| ...:|
  Fly   141 T---------------------------AYHLAVQGGSLIRIPPVNQTIREGQTAFFHC-VMKHP 177

Human   255 ANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTV 319
            .|...||::|.:.:..:..|..|..:..||||.:..|...|.|.|.|...|......:|.|:|.:
  Fly   178 ENSQASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNI 242

Human   320 LYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIAL 384
            .|.|:|...|||..||.|.|.|:.|..||||||..:.|.|||........||......|||..|.
  Fly   243 QYKAKVIYAPPEVFLPYGQPAVLDCHFRANPPLKNLRWEKDGLLFDSYNVPGVFYKMNGSLFFAK 307

Human   385 GNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSA---QGDP 446
            .:|:..|.|:|||||.|||.|||||..|::..||.|...||..|.|::|....:||.|   .|:.
  Fly   308 VDENHAGSYTCTPYNDLGTDGPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPCEAIDRDGNN 372

Human   447 PPVVSW-TKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHV 510
            .|.:.| .|.|:.|.......|..:|.:..|.:...|.:||||:|..|.:.....:.:...:|..
  Fly   373 RPSIIWGRKDGQPLPADRFSLSGGNLTITGLVEGDRGIYECSATNEAATITAEAELMIENIAPRA 437

Human   511 VTNVSVVALPKGANVSWEPGFDGGYLQ---RFSVWYTPLAKRPDRMHHDWVSLAV-PVGAAHLLV 571
            ..|::..:......:.|:|    |||:   .::|||. |.:.|     :|.:|.| ........|
  Fly   438 PYNLTANSTETCITIRWQP----GYLRPNLEYTVWYR-LMEAP-----EWRTLRVLDKKVMEATV 492

Human   572 PGLQPHTQYQFSVLAQNKLGSGPFSE----IVLSAP--------------EGLPTTPAAPGLPPT 618
            ..|||..:|:|.||:|:|.|.|.||:    ..|.:|              .|..|.||.
  Fly   493 QHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQHDLGQVTAPAG------ 551

Human   619 EIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQG-----SQGWEVLDPAVAG-T 677
                .|..|..|.|:...:|.||||:.|           ::|.:|     .:.|:..:..:.| .
  Fly   552 ----GLGAPWNLTAISNQQGWLLHWEHP-----------VQGLEGLRLYAVRWWKEPEHFLIGHA 601

Human   678 ET---ELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQ-PVLAG 738
            ||   ...:..|.:|.|::.:::|              |.|...:..||...|..:..| .|.|.
  Fly   602 ETFDNYYQLRHLKEDTLFKVQVLA--------------VGTETQQSVPSHELLIDVPSQRKVRAL 652

Human   739 VVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDS 800
            ::|.  .:||..|:..|...|..:|...|.          |....:..|.......||..||
  Fly   653 IIGS--SVGVIFLLCALCAFLYVKRSCLRH----------LFAKDSSASEDEDTAESGDCDS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	25/115 (22%)
		IG_like	28..110	CDD:214653	21/89 (24%)
		I-set	136..223	CDD:254352	7/86 (8%)
		Ig	154..220	CDD:143165	4/65 (6%)
		Ig_3	226..305	CDD:290638	23/78 (29%)
		IG_like	233..319	CDD:214653	25/85 (29%)
		Ig	341..404	CDD:299845	28/62 (45%)
		IG_like	431..503	CDD:214653	20/75 (27%)
		Ig	436..500	CDD:143165	19/67 (28%)
		fn3	511..596	CDD:278470	26/88 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		4/19 (21%)
		FN3	625..715	CDD:238020	20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
bdl	NP_608822.1	IG_like	42..128	CDD:214653	22/100 (22%)
		Ig	43..131	CDD:299845	23/102 (23%)
		I-set	153..242	CDD:254352	27/89 (30%)
		Ig	157..242	CDD:299845	25/85 (29%)
		Ig_2	252..337	CDD:290606	42/84 (50%)
		IG_like	260..327	CDD:214653	30/66 (45%)
		I-set	341..428	CDD:254352	26/86 (30%)
		IGc2	356..419	CDD:197706	19/62 (31%)
		FN3	435..524	CDD:238020	29/98 (30%)
		FN3	554..636	CDD:238020	21/106 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9436
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.780