DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and Fas2

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	216/940 - (22%)
Similarity:	332/940 - (35%)	Gaps:	216/940 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    34 GESVVLGCDLLPPAGRPPLHV-IEWL--RFGFLLPIFIQFGLYSP--RIDPDYVGRVRLQKGASL 93
            |:.::|.|  .|....|.|.. ::|.  |...:||        .|  |..|.........:..:|
  Fly    47 GKPLILTC--RPTVPEPSLVADLQWKDNRNNTILP--------KPNGRNQPPMYTETLPGESLAL 101

Human    94 QIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRC 158
            .|..|.||..|.|.|...:.:..|.|......::|.:|..:.|:.|.....       :...:.|
  Fly   102 MITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLG-------QDYVVMC 159

Human   159 VARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTE-GSATHAT-QL 221
            ..:..|.|.:.|...|..:.....:..||...|.||.|:....|:|||:|:..| |.....| ::
  Fly   160 EVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRV 224

Human   222 LVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQD--NINVFHISRLQ--PRVRILV 282
            .|...|.|:..|.|......:..:..|.|...|.. ..||.:|  .:||....|.|  |:.
  Fly   225 EVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVP-EISWIRDATQLNVATADRFQVNPQT---- 284

Human   283 DGSLRLLATQPDDAGCYTCVPSN--GLLHPPSASAYLTVLYPAQV-------TAMPPETPLPIGM 338
             |.:.:.:...||.|.|||:..|  |::   .....|.||...|:       .|...|..:
  Fly   285 -GLVTISSVSQDDYGTYTCLAKNRAGVV---DQKTKLNVLVRPQIYELYNVTGARTKEIAI---- 341

Human   339 PGVIRCPVRANPPLLFVSW-----------TKDGKAL---QLDKFPGWSQGTEGSLIIALGNEDA 389
              ..|...|..|.:.|..|           ..|.:.:   ..|:..|.|.||   |.|:......
  Fly   342 --TCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGT---LRISNAERSD 401

Human   390 LGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKE--EYFQEVGRELLIPCSAQGDPPPVVSW 452
            .|.|.|...|.  .|.......:.::..|.| ...||  ..|....|:..:.|.|.|.|...:.|
  Fly   402 DGLYQCIARNK--GADAYKTGHITVEFAPDF-SHMKELPPVFSWEQRKANLSCLAMGIPNATIEW 463

Human   453 TKVGRGLQGQAQVDSN---------SSLILRPLTKEAHGHWECSASN-----------AVARVAT 497
            ...||.::.  ..|:|         |.||:.|:|::.:..::|.|:|           ..|||..
  Fly   464 HWNGRKIKD--LYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD 526

Human   498 STNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAV 562
                :|....|..:|..::....:|.  |.|.|..   :..:||.|      .:.::.||
  Fly   527 ----FVSEAKPSQLTATTMTFDIRGP--STELGLP---ILAYSVQY------KEALNPDW----- 571

Human   563 PVGAAH---------LLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPT 618
              ..|:         .:|.||:|.|:|.|...|:|::|.|.:         |:....:.|.....
  Fly   572 --STAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNW---------GVNQQQSTPRRSAP 625

Human   619 EIPPPLSPP----RGLVAVRTPRG--VLLHWDPPELVPKRLDGYVLE---GRQGSQGWEVLDPAV 674
            |.|.||..|    :....|.:|..  ..|.|..|....:.:|.|.::   |.:.|..|..|:.:.
  Fly   626 EEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSC 690

Human   675 AGTE----TELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPV 735
            ...|    |...:..|:.:..|...|.|......|.|::....:|.|::|.....:  .:.....
  Fly   691 NTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAER--QVFSSAA 753

Human   736 LAGV-VGGVCFLGVAV----LVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGS 795
            :.|: :|||..|...|    .:::..|.:....|.|:|                    :||.:
  Fly   754 IVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKR--------------------SPSEI-- 796

Human   796 GSPDSVAKL-KLQG--SPVPSLRQSLLWGDPAGTPSPHP-DPPSSRGPLPL-------EPICRGP 849
               |..||| .|.|  .|:|.....|:...|   |||.| .||...|..|:       ||: |.|
  Fly   797 ---DDEAKLGSLYGWRFPLPYCSGQLVKEPP---PSPLPLPPPVKLGGSPMSTPLDEKEPL-RTP 854

Human   850 ------------DGRFVMGPTVAAPQERSG 867
                        |||||        ..|||
  Fly   855 TGSIKQNSTIEFDGRFV--------HSRSG 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	24/102 (24%)
		IG_like	28..110	CDD:214653	21/80 (26%)
		I-set	136..223	CDD:254352	21/88 (24%)
		Ig	154..220	CDD:143165	19/67 (28%)
		Ig_3	226..305	CDD:290638	22/82 (27%)
		IG_like	233..319	CDD:214653	23/91 (25%)
		Ig	341..404	CDD:299845	17/76 (22%)
		IG_like	431..503	CDD:214653	21/91 (23%)
		Ig	436..500	CDD:143165	20/83 (24%)
		fn3	511..596	CDD:278470	22/93 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		5/19 (26%)
		FN3	625..715	CDD:238020	20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919		33/124 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	23/95 (24%)
		IG_like	144..226	CDD:214653	21/88 (24%)
		IGc2	152..209	CDD:197706	15/63 (24%)
		I-set	230..319	CDD:254352	25/97 (26%)
		IGc2	243..309	CDD:197706	19/71 (27%)
		IG_like	330..424	CDD:214653	20/104 (19%)
		IGc2	339..412	CDD:197706	16/81 (20%)
		Ig	447..518	CDD:143165	17/72 (24%)
		fn3	534..611	CDD:278470	22/94 (23%)
		FN3	640..735	CDD:238020	19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810