DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and rst

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	808	Identity:	167/808 - (20%)
Similarity:	253/808 - (31%)	Gaps:	277/808 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    34 GESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPI------FIQFGLYSPRIDPDYVGRVRLQKGAS 92
            |..|.|.|.::...|     .::|.:..|.|..      |.::.:.....:.||          |
  Fly    42 GARVTLPCRVINKQG-----TLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDY----------S 91

Human    93 LQIEGLRVEDQGWYECRVFFLDQHIPEDDFA-NGSWVHLTVNSPPQFQE-TPPAVLEVQELEPVT 155
            |.|..:.::|...|:|:|    ...||...| ..::..|||..||:..: |...|:...|...|.
  Fly    92 LDIYPVMLDDDARYQCQV----SPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVE 152

Human   156 LRCVA-RGSPLPHVTWKLRGKDLGQGQGQVQVQN-----------------GTLRIRRVERGSSG 202
            :.||: .|.|...:||.       .|.|.|...|                 ..||:...:...:.
  Fly   153 IECVSVGGKPAAEITWI-------DGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNT 210

Human   203 VYTCQASSTEGSATHATQLLV---LGPPVIV-----VP-----------------PKNSTVNASQ 242
            .::|||.:|......:.::.|   ..|.|.|     :|                 ...|.:....
  Fly   211 NFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHS 275

Human   243 DVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS-----LRLLATQPDDAGCYTCV 302
            .|.|.|.|:|.|:::.|.||.::         :|    ::.|.     :|.:..:..|| ...|.
  Fly   276 QVRLECRADANPSDVRYRWFIND---------EP----IIGGQKTEMVIRNVTRKFHDA-IVKCE 326

Human   303 PSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLD 367
            ..|. :.....|..|.:.|.......|......:|....:.|.|.:||....|
  Fly   327 VQNS-VGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIV------------ 378

Human   368 KFPGWSQ-------GTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPK 425
                |.|       ||..:|..::.||.| |.|.|.. |..|.|..|....|.||..|| |...:
  Fly   379 ----WIQHPSDRVVGTSTNLTFSVSNETA-GRYYCKA-NVPGYAEISADAYVYLKGSPA-IGSQR 436

Human   426 EEYFQEVGRELLIPCSAQGDP-PPVVSWTKVGRGLQGQAQVDSN-----------SSLILRPLTK 478
            .:| ..||....|.|.|...| ...||||..|:.:..::..|.:           |:||:|....
  Fly   437 TQY-GLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQA 500

Human   479 EAHGHWECSASN------AVARVATSTNVYVLGTSPHVVTNVSVVA------------------- 518
            ..:|.:.|:..|      |..::....:|.:|.|   :|..:||||
  Fly   501 YHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMT---IVGGISVVAFLLVLTILVVVYIKCKKRT 562

Human   519 -LPK-------------GANVSWEPG------------FDGGYLQ--RFSVWYTP---------- 545
             ||.             |.:...|||            ..|||:.  .:|..|:|
  Fly   563 KLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCST 627

Human   546 ------------------LAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQ---YQFSVLAQNK 589
                              |.::..:.||                   |.|||   ...:.|..:.
  Fly   628 KSNGSSTIMQNNHQNQLQLQQQQQQSHH-------------------QHHTQTTTLPMTFLTNSS 673

Human   590 LGS---------------------GPFSEIVLSAPEG----LPTTPA--------APGLPPTEIP 621
            .||                     ...:.:|.|:|.|    ..||.|        .|......:.
  Fly   674 GGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVD 738

Human   622 PPLSPPRGLVAVRTPRGVLLHWDPPELV 649
            |..|...|...:|:....||  .||..|
  Fly   739 PRYSAIYGNPYLRSSNSSLL--PPPTAV 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	22/104 (21%)
		IG_like	28..110	CDD:214653	17/81 (21%)
		I-set	136..223	CDD:254352	21/105 (20%)
		Ig	154..220	CDD:143165	17/83 (20%)
		Ig_3	226..305	CDD:290638	20/105 (19%)
		IG_like	233..319	CDD:214653	19/90 (21%)
		Ig	341..404	CDD:299845	18/69 (26%)
		IG_like	431..503	CDD:214653	21/89 (24%)
		Ig	436..500	CDD:143165	18/81 (22%)
		fn3	511..596	CDD:278470	27/183 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		5/27 (19%)
		FN3	625..715	CDD:238020	8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
rst	NP_001284835.1	IG_like	34..130	CDD:214653	24/106 (23%)
		Ig	42..114	CDD:299845	18/90 (20%)
		C2-set_2	135..225	CDD:285423	20/96 (21%)
		Ig_3	265..329	CDD:290638	16/77 (21%)
		I-set	346..420	CDD:254352	21/91 (23%)
		Ig	360..425	CDD:299845	21/82 (26%)
		Ig5_KIRREL3-like	428..524	CDD:143235	24/97 (25%)
		IG_like	435..524	CDD:214653	21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900