DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and igcm-2

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	876	Identity:	207/876 - (23%)
Similarity:	333/876 - (38%)	Gaps:	191/876 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    16 QGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPD 80
            |..||    |:.:..|:||..:.|.|.:  .........::|.:.|.|  |...||.....:.|.
Worm    14 QTDDG----EMKAYWGKAGAPITLPCSI--SLFNEESFSLDWRKDGQL--ILSAFGQEQGHVTPT 70

Human    81 YVGRVRLQKGASLQIEGLRVEDQGWYECRV--FFLDQHIPEDDFANGSWVHLTVNSPPQ-FQETP 142
            ..||:.......:.|..:...|.|.|:|.|  |......||    .|....|.||.||. ...:.
Worm    71 LQGRLARDGFLGITIHSVTDGDAGVYQCIVTKFSKQPTRPE----KGLSAKLVVNVPPVIISPSK 131

Human   143 PAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQ 207
            .|::..:....:...|.|.|:|.|.:||. |.:       |:...:..|.:..:|.|..|:|||.
Worm   132 NAIIHKKVGADLIFECKAEGAPSPEITWS-RNE-------QIISTSPVLTLSNLEEGDKGLYTCL 188

Human   208 ASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHIS 272
            |.:.||::|.:..:......::.:.|.|.||....:|...|||.|....::|||..:...:...|
Worm   189 AVNIEGNSTSSIDVRFTKATILDLIPLNKTVIEGSNVFWHCHANAQATAISYSWLFEKKPIKTTS 253

Human   273 -RLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ-VTAMPPETPLP 335
             .|:..:|   .|.|.|...:..|:|.|||...|......|::|||.|.||.: :::..|...:.
Worm   254 LGLRSNIR---SGDLSLQDVRKSDSGWYTCEAKNSAGETTSSTAYLHVFYPPEPLSSHQPVQTVA 315

Human   336 IGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGS--LIIALGNEDALGEYSCTPY 398
            .|....:.|.|.|||.....:|:|:|..|.          |:.|  :||:.......|.|.|...
Worm   316 SGRNTTVSCDVIANPTPTSYTWSKNGHYLP----------TQASSHIIISYAKPGDGGIYGCQAD 370

Human   399 NSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQA 463
            |..| .|....|.:::..||.|...|..|....:|.::.|||...|||.|:|.|.:..:.:
Worm   371 NIAG-KGSIVETHLIVAEPPVFTVAPPSEIKVRLGDQVSIPCQGFGDPMPIVYWIRDKKRI---- 430

Human   464 QVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGA-NVSW 527
               :.|:|..:.:....||.:||..:|:|..::|...:.|..|.|.:.:::....|...: .:||
Worm   431 ---NQSTLTFKKVEHLDHGAYECVVANSVETISTRVMLLVEITKPQMASSIKFTCLNSSSMRISW 492

Human   528 EPGFDGGYLQRFSVWYTPLAKRPDRMHHD----WVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQN 588
            .||::||:.|.|:|          ...:|    |.|:...:.  ..::..|:|...|:.|:.:.|
Worm   493 TPGYNGGFDQTFAV----------HAQNDVTLQWTSIKTSLN--ETILDHLEPFVSYRVSIESVN 545

Human   589 KLGS---------------GP-------FSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLV 631
            ..||               .|       ::|:..:|.||..:........|::...||:
Worm   546 AKGSTNSTTYNRRSCTSLHAPDKLYFCGYNELCWTAAEGASSYRIESRTEPSKNFQPLA------ 604

Human   632 AVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRL 696
                               :.|:.|...|:.       :|      ||:..:          ||:
Worm   605 -------------------EVLETYYRLGKD-------VD------ETKQTI----------FRV 627

Human   697 VAFAGSF-VSDPSNTA------NVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSI 754
            .:...|: .|:|||..      ||.                ||..:||.|.|        :|...
Worm   628 RSTRPSYPPSEPSNALRYGIADNVD----------------LPIFMLAAVFG--------LLFCF 668

Human   755 LAG-----CLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSL 814
            ..|     |..|:.:.::||:.|....|...:...|:........|..|.:....:      |||
Worm   669 ACGLFAWRCFHNKNKKSKRRKSRSNSTPSKTYQDYGRFTYGDGSSSSQPGTETYYE------PSL 727

Human   815 RQSLLWGDPAGTPSPHPDPPSSRGPLPLEPI 845
            |  ||            |....|||..|||:
Worm   728 R--LL------------DDHEWRGPRDLEPV 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	26/109 (24%)
		IG_like	28..110	CDD:214653	19/81 (23%)
		I-set	136..223	CDD:254352	22/87 (25%)
		Ig	154..220	CDD:143165	20/65 (31%)
		Ig_3	226..305	CDD:290638	23/79 (29%)
		IG_like	233..319	CDD:214653	28/86 (33%)
		Ig	341..404	CDD:299845	18/64 (28%)
		IG_like	431..503	CDD:214653	19/71 (27%)
		Ig	436..500	CDD:143165	18/63 (29%)
		fn3	511..596	CDD:278470	21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		3/19 (16%)
		FN3	625..715	CDD:238020	15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919		20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	19/81 (23%)
		Ig	124..200	CDD:386229	22/83 (27%)
		IG_like	214..298	CDD:214653	28/86 (33%)
		Ig_3	309..371	CDD:372822	18/71 (25%)
		Ig	389..467	CDD:386229	23/84 (27%)
		FN3	476..548	CDD:238020	18/83 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I8042
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm15902
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.670