DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK7 and smal

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_723165.2	Gene:	smal / 5740323	FlyBaseID:	FBgn0085409	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	245	Identity:	56/245 - (22%)
Similarity:	82/245 - (33%)	Gaps:	75/245 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   180 GQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVV 244
            |:|:|:.||.     ....||:|||:|.....:...:|.:......|..:.|.|....|
  Fly   701 GKSSHSHSSH-----CSTGGPDHSGIYDDGIGTMNSKATAPMINPYSSGNSSSAAAAAA------ 754

Human   245 ARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRN------ 303
            |.::.|..: .|.:.|.   ...||....:. .:.|..:..||..| ||..:.: :|::
  Fly   755 AEFQRARTY-NFRSYPD---NLXFEASLKLV-AAAPKRITAATASA-GSTTMPK-KPQHLSLVAS 812

Human   304 -AGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEER--------------VTCLP 353
             ||.|.|   |....| ....|||          ..::.|.|...|              |..:|
  Fly   813 TAGGYGC---GTSSKP-KYSLTLH----------NSKLATGGKHLRDGLQQRQHLKAVDGVGLVP 863

Human   354 -PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAA 402
             |..||...|    .||.|.                 |.|:||..|..|:
  Fly   864 VPVTLPVDEV----VGVHLK-----------------AGSEAGAATGEAS 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237	13/49 (27%)
		IG_like	239..>309	CDD:214653	16/76 (21%)
		Ig	250..310	CDD:143165	15/66 (23%)
		IG	348..416	CDD:214652	16/70 (23%)
		IGc2	348..406	CDD:197706	16/70 (23%)
		I-set	420..506	CDD:254352
		Ig	422..506	CDD:299845
		I-set	511..596	CDD:254352
		IGc2	528..582	CDD:197706
		IG_like	606..689	CDD:214653
		IGc2	613..677	CDD:197706
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
smal	NP_723165.2	FA58C	78..234	CDD:214572
smal	NP_723165.2	FA58C	81..233	CDD:238014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910