DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTK7 and Alk

DIOPT Version :9

Sequence 1:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens
Sequence 2:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster


Alignment Length:438 Identity:140/438 - (31%)
Similarity:233/438 - (53%) Gaps:64/438 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   665 EDSGRYTCIAGNSCNIK---HTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYI-I 725
            |...:..||..:..::|   ||...:        .|..|..|   ::.:.:| |.:..||.:| |
  Fly  1068 EFRSKVRCICPDGWSLKRDNHTACEI--------REEAGKSS---FQYLVSI-LMISLAVLFICI 1120

Human   726 AVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 790
            |.|..|.|       .|.|::.:.::              :....:::::.||.|.:....:|..
  Fly  1121 AALIFMLY-------NRYQRKKQSKK--------------RHKMLVEQDLQLTRLRNNIDDSNLN 1164

Human   791 HSTS------------DKMHFP---RSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSL 840
            :...            |....|   |.|||.:..|||..||||::|..:..:....|..|.||:|
  Fly  1165 NFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTL 1229

Human   841 QS--KDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDE 903
            :.  |.|::: ||.:|..:..|.||.|:|.|:|:|.:.:|:|:|||.:..|||::|||.:::..|
  Fly  1230 REDPKREKEE-DFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPE 1293

Human   904 KLKSQPLSTKQKVALCT-QVALGMEHLSNNRFVHKDLAARNCLVSAQ---RQVKVSALGLSKDVY 964
            :   ..|.|.:.:..|. .||.|..::.:.||:|:|:||||||:|::   |.||::..|:|:|:|
  Fly  1294 R---PSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIY 1355

Human   965 NSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1028
            .|:||. ..:|.:|::||.|||.|:|.|::|:|||:||:|:||||:.|..|:.||.:.:|: :|.
  Fly  1356 RSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVM-ELV 1419

Human  1029 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDS 1076
            ....||..|..||..:|::|..||..:|:|||:|..:...|...|.|:
  Fly  1420 VRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDA 1467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK7NP_001257327.1 IG_like 46..120 CDD:214653
IGc2 53..113 CDD:197706
Ig2_PTK7 154..230 CDD:143237
IG_like 239..>309 CDD:214653
Ig 250..310 CDD:143165
IG 348..416 CDD:214652
IGc2 348..406 CDD:197706
I-set 420..506 CDD:254352
Ig 422..506 CDD:299845
I-set 511..596 CDD:254352
IGc2 528..582 CDD:197706
IG_like 606..689 CDD:214653 6/26 (23%)
IGc2 613..677 CDD:197706 3/11 (27%)
PTK_CCK4 798..1071 CDD:133178 112/282 (40%)
STYKc 809..1069 CDD:214568 106/266 (40%)
AlkNP_001261027.1 MAM 288..450 CDD:279023
MAM 288..447 CDD:99706
MAM 505..691 CDD:279023
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 112/280 (40%)
TyrKc 1193..1460 CDD:197581 108/271 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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