DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and sns

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	203/911 - (22%)
Similarity:	314/911 - (34%)	Gaps:	292/911 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    12 SAPTVGSAMEKKEFPTPPGRVGPGTQTAIVFIKQPSSQDALQGRRALLRCEV-EAPGPVHVYWLL 75
            |||....|.::|                  |...|.....|:|..|::|||| ...|.|.  |..
  Fly    62 SAPVPSHAQQQK------------------FRTTPHDLQVLEGAEAMMRCEVANVAGAVQ--WTK 106

Human    76 DGAPVQDTERRFAQGSSLSFAAV-----------DRLQ-------------DSGTFQCVARDDVT 116
            ||         ||    |.|:||           ||.|             |...:||.......
  Fly   107 DG---------FA----LGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARL 158

Human   117 GEEARSANASFNIKWIEAGPVVLKHPA----------SEAEIQPQTQVTLRCHIDGHPRPTYQ-- 169
            ....| |||..         .|:..||          |:.|::....:.|:| |..:.:|..|
  Fly   159 NSAIR-ANAKL---------TVISPPASIEIKGYSHNSKVEVRENQDLQLKC-IVANAKPAAQIV 212

Human   170 WFRDGTPLSDGQSNHTV--SSKER-----NLTLRPAGPEHSGLYSCCA-HSAF------------ 214
            |:|........:...||  |:.:|     :|.|:|...:....|:|.| |.|.
  Fly   213 WYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQL 277

Human   215 ----------------------GQA----CSSQ-------------------------------- 221
                                  ||.    |.|:
  Fly   278 SVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIY 342

Human   222 NFTLSIADESFAR---------------------VVLAPQDVVVARYEEAM------FHCQFS-A 258
            .||....|.. ||                     |:.||..|.|....||.      ..|..: :
  Fly   343 TFTAEAGDNK-ARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPS 406

Human   259 QPPPSLQWLFEDETPITNRSRPPHLRRAT----VFANGSLLLTQ-----VRP-RNAGIYRCIGQG 313
            .||..::|:      :..|    .:|.||    |...|....|.     |.| :.:.:..|.|..
  Fly   407 NPPAEIKWM------VGGR----QVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLN 461

Human   314 -QRGPPIILEATLHLAEIEDMPL----FEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPT 373
             |....::...|:::......||    .|.::..|||.:::.|:...|.|..::.|.....|:.:
  Fly   462 MQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINS 526

Human   374 HGRVYQK---GHELVLANIAESDAGVYTCHAANLAGQ--RRQDVNITVATVPSWLK-KPQDSQLE 432
            ..|...|   ....:|||::::.| .|.|.|:|.|.:  ..|...::|...|..:| :.:..:|.
  Fly   527 VIRAADKSVSAEITILANVSDNQA-QYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELR 590

Human   433 EGKPGYLDC-LTQATPKPTVVWYRNQMLISEDSRFEVFKN--------GTL-----RINSVEVYD 483
            .|....:.| .:.:.|...:.|:::.:.|      |...|        ||:     |:|..:..:
  Fly   591 PGMEATIICDSSSSNPPAKLSWWKDGIPI------EGINNTSKPGLWGGTVSTLEFRVNVTQEMN 649

Human   484 GTWYRCMSSTPA--GSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKP-TIKWE 545
            |..|.|.|:..|  .|......:.||.:.||.|||.........:...|.........| |.||.
  Fly   650 GQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWT 714

Human   546 RADGSSLPE----WVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEP 606
            : ||:::|:    .:..:.|:|:|.|:.|||||.|:|.|||. ||....::.:.|....|.|...
  Fly   715 K-DGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNS-QGGATLNITVVVEYGTTIKSVS 777

Human   607 ERTTVYQGHTALLQCEAQGDPKPL----IQWKGKDRILDPTKLGPRMHI-----FQNGSLVIH-- 660
            |...|..|..|:|.|..:|  |||    ::|:         ::|..|.:     |.||:..:|
  Fly   778 ENIVVNPGEDAMLSCTVEG--KPLTEEHVKWE---------RVGYDMTVKTSTTFANGTSYLHIK 831

Human   661 DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP--------------------GSPP 705
            |...||.|.:.|:|.|..: ..|...:.::.|..||.::.|                    |||.
  Fly   832 DAKREDVGNFRCVADNRVD-NPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPK 895

Human   706 P 706
            |
  Fly   896 P 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653	25/98 (26%)
		IGc2	53..113	CDD:197706	23/84 (27%)
		Ig2_PTK7	154..230	CDD:143237	25/155 (16%)
		IG_like	239..>309	CDD:214653	18/86 (21%)
		Ig	250..310	CDD:143165	14/76 (18%)
		IG	348..416	CDD:214652	17/72 (24%)
		IGc2	348..406	CDD:197706	15/60 (25%)
		I-set	420..506	CDD:254352	20/102 (20%)
		Ig	422..506	CDD:299845	19/100 (19%)
		I-set	511..596	CDD:254352	29/89 (33%)
		IGc2	528..582	CDD:197706	20/58 (34%)
		IG_like	606..689	CDD:214653	25/93 (27%)
		IGc2	613..677	CDD:197706	21/74 (28%)
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
sns	NP_001036532.1	I-set	73..170	CDD:254352	31/139 (22%)
		Ig	76..155	CDD:299845	25/93 (27%)
		IG_like	186..279	CDD:214653	21/93 (23%)
		Ig	197..279	CDD:299845	19/82 (23%)
		IG_like	296..376	CDD:214653	9/80 (11%)
		Ig	300..361	CDD:299845	9/61 (15%)
		Ig	380..454	CDD:299845	18/83 (22%)
		IG_like	490..573	CDD:214653	21/83 (25%)
		Ig	501..560	CDD:299845	15/59 (25%)
		Ig	584..666	CDD:299845	17/87 (20%)
		IG_like	585..666	CDD:214653	17/86 (20%)
		I-set	678..767	CDD:254352	29/90 (32%)
		IGc2	692..757	CDD:197706	22/66 (33%)
		Ig	788..849	CDD:143165	21/71 (30%)
		Ig	885..960	CDD:143165	4/12 (33%)
		FN3	967..1051	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910