DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and sls

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001261304.1	Gene:	sls / 44013	FlyBaseID:	FBgn0086906	Length:	18468	Species:	Drosophila melanogaster

Alignment Length:	1116	Identity:	234/1116 - (20%)
Similarity:	377/1116 - (33%)	Gaps:	353/1116 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    79 PVQDTERRFAQ-----GSSLSFAAVDRLQD---SGTFQCVARDDVTGEE--ARSANASFNIKWIE 133
            |.|...::..|     ....|.::.::.|:   |.|.|.|.|..||.:.  .:....|....::
  Fly     8 PYQQQNQQHQQVQQFSSQEYSHSSQEQHQEQRISRTEQHVQRSQVTTQRQVQQHHGGSIGGAYV- 71

Human   134 AGPVVLKHPASEAEIQPQT--------------QVTLRCHIDGHPRPTYQWFRDGTPLSDGQS-- 182
              |..|.|..::.:|.|..              .......:.|:|:|...|.|.|.||.:.|.
  Fly    72 --PPSLTHVYAQGDISPPVFEQIFKNARFAQGGNALFEGRLRGNPKPFVTWTRKGAPLLESQKFR 134

Human   183 -NHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQA-CSSQNFTLSIADESFARVVLAPQDVVVA 245
             ::..::.:.:|.:...||...|.|:|.|.:.:|:| ||               |.:.|:
  Fly   135 MSYNEATGDVSLLINQIGPGDEGEYTCTARNQYGEAICS---------------VYIQPE----- 179

Human   246 RYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANG----SL------------ 294
                        ..|.|:||       ||.|..:       .:::||    |:
  Fly   180 ------------GAPMPALQ-------PIQNLEK-------NIYSNGYSYTSIEEEFRVDTFEYR 218

Human   295 LLTQVRPRNAGIYRCIGQGQ-----------RGPPIILEATLHLAEIEDMP----LFE--PRVFT 342
            ||.:|..|.| |.|..|..|           :||       ....:|...|    |.|  ..|||
  Fly   219 LLREVSFREA-ITRRSGYEQDSQLSQELDRNQGP-------AQAPQISQKPRSSKLIEGSDAVFT 275

Human   343 A--GSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRV---YQKG-HELVLANIAESDAGVYTCHA 401
            |  ||.           |:|.:.|.|.|.||....:.   |..| ..|.:.|....|.|.||..|
  Fly   276 ARVGSN-----------PKPRLTWFHNGQRLVASQKYEISYSSGVATLRVKNATARDGGHYTLLA 329

Human   402 ANLAG-----------------QRRQDVNITV-------ATVPSWLKKPQDSQLEEGKPGYLDCL 442
            .||.|                 ...:.|::..       |..|:::|...|.::.||:....||.
  Fly   330 ENLQGCVVSSAVLAVEPAAETAYEPKPVDVMAEQLEAGKALPPAFVKAFGDREITEGRMTRFDCR 394

Human   443 TQATPKPTVVWYRNQMLISEDSRFEVFKN----GTLRINSVEVYDGTWYRCMSSTPAGSIEAQAR 503
            ....|.|.|.|..|...:.:|:..::..|    .:|.|.:|...|....:|::...||.:..:|:
  Fly   395 VTGNPYPEVFWLINGRQVRDDASHKILVNESGSHSLMITNVTRLDAGAVQCLARNKAGEVAIEAQ 459

Human   504 VQVLEKLKFTPPPQPQQ----CMEFDKEATVPCSATGREKPTIKWERADG---SSLPE---WVTD 558
            :.||||.:...|...|:    .:...:..|:..:|.|..:|.|.|:: ||   ||..|   .:..
  Fly   460 LNVLEKEQVVAPQFVQRFSTMTVREGEPITMSANAIGTPQPRITWQK-DGVQISSTAERFVGIDG 523

Human   559 NAGTLHFARVTRDDAGNYTCIASN----------------------------------------- 582
            .|..|...|||.:|||.|.|.|.|
  Fly   524 GATCLEIPRVTANDAGWYQCTAQNIAGSTANRARLYVEVPREQPNYEQRRLNLPRPTKVIEPEPI 588

Human   583 -GPQGQIRAHVQLTVAVFITFKVEP-----ERTTVY-------------QGHTALLQCEAQ---- 624
             ||:.....||:         :.:|     |...||             |.....:..||:
  Fly   589 PGPEIIYLRHVE---------RAKPHLRPGEEDRVYPPPQFIIPLQNVQQTEGGRVHMEARIEPV 644

Human   625 GDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYV 689
            |||..:::|....|.|..:.....:..|...:|.:..:...|||.|.|...|:..:..:.|.|.|
  Fly   645 GDPTMVVEWYLNGRPLAASARATSVFKFGFIALDLLSIMGHDSGEYMCRVTNASGVAESRAILSV 709

Human   690 VDKP-VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPE 753
            |.:| :.:.|:.|.|                 :.||..:.....|.:.....::|.:.|:...|.
  Fly   710 VQRPSIEQSSQNPNS-----------------LQYINQLEDYSRYQRTESIDEQLNQAPQFIRPL 757

Human   754 MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK----SE 814
            .:.   |..:.|:   .:..|..:|.:          :..|.::.:.:..| |||...:    ..
  Fly   758 RDL---GEFEEGK---NVHFEAQVTPV----------NDPSMRVEWYKDGL-PITASSRITAIFN 805

Human   815 FGEVFL------AKAQG---------LEEGVAETLVLVKS-------LQSKDEQQQLDFRRELEM 857
            ||.|.|      |:..|         :.|.::::.:.|.|       |...::|:.::...|||.
  Fly   806 FGYVSLNILHLRAEDAGTYTVRAVNRIGEAISQSSIRVHSRSQVTADLGIPEQQRYIEKVEELED 870

Human   858 FGKLNHANVVR-----------------LLGLCREAEPHYMV-LEYVDLGDLKQFLRISKSKDEK 904
            :.|......|:                 .|.|...|..|:.. ||.|  ||  ..:|:...||
  Fly   871 YRKSQQRRHVQEAAEAIAPPQFKTPIQNQLDLREHAHAHFEARLEPV--GD--STMRVEWLKD-- 929

Human   905 LKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALG----------L 959
              .|||....::.  |....|...|:..:....|.....|..       .:|:|          :
  Fly   930 --GQPLEASSRIT--TYHNFGYVALTIKQLTIYDAGTYTCRA-------YNAMGQDTTVAQLTVI 983

Human   960 SKDVYNSEYYH 970
            ||:...||..|
  Fly   984 SKNEIVSESQH 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653	12/50 (24%)
		IGc2	53..113	CDD:197706	9/41 (22%)
		Ig2_PTK7	154..230	CDD:143237	20/79 (25%)
		IG_like	239..>309	CDD:214653	17/85 (20%)
		Ig	250..310	CDD:143165	17/75 (23%)
		IG	348..416	CDD:214652	20/88 (23%)
		IGc2	348..406	CDD:197706	18/61 (30%)
		I-set	420..506	CDD:254352	22/89 (25%)
		Ig	422..506	CDD:299845	21/87 (24%)
		I-set	511..596	CDD:254352	29/136 (21%)
		IGc2	528..582	CDD:197706	22/59 (37%)
		IG_like	606..689	CDD:214653	23/104 (22%)
		IGc2	613..677	CDD:197706	16/67 (24%)
		PTK_CCK4	798..1071	CDD:133178	47/227 (21%)
		STYKc	809..1069	CDD:214568	43/216 (20%)
sls	NP_001261304.1	I-set	87..174	CDD:254352	20/101 (20%)
		Ig	109..175	CDD:143165	20/80 (25%)
		Ig	254..334	CDD:299845	28/90 (31%)
		I-set	255..344	CDD:254352	29/99 (29%)
		I-set	372..462	CDD:254352	22/89 (25%)
		Ig	390..463	CDD:299845	17/72 (24%)
		Ig	471..561	CDD:299845	25/90 (28%)
		I-set	471..560	CDD:254352	25/89 (28%)
		I-set	618..709	CDD:254352	19/90 (21%)
		Ig	645..705	CDD:143165	14/59 (24%)
		DUF1136	715..741	CDD:284093	6/42 (14%)
		IG_like	762..843	CDD:214653	15/94 (16%)
		Ig	779..835	CDD:143165	11/56 (20%)
		I-set	890..982	CDD:254352	22/108 (20%)
		Ig	918..979	CDD:143165	15/75 (20%)
		DUF1136	988..1014	CDD:284093	3/7 (43%)
		I-set	1024..1116	CDD:254352
		Ig	1058..1113	CDD:143165
		I-set	1158..1250	CDD:254352
		Ig	1178..1246	CDD:143165
		DUF1136	1256..1282	CDD:284093
		I-set	1291..1380	CDD:254352
		IGc2	1304..1372	CDD:197706
		DUF1136	1388..1414	CDD:284093
		I-set	1424..1515	CDD:254352
		Ig	1442..1513	CDD:143165
		DUF1136	1522..1548	CDD:284093
		I-set	1558..1645	CDD:254352
		IGc2	1571..1639	CDD:197706
		DUF1136	1655..1679	CDD:284093
		I-set	1691..1782	CDD:254352
		IGc2	1718..1772	CDD:197706
		DUF1136	1788..1814	CDD:284093
		I-set	1824..1916	CDD:254352
		IGc2	1838..1906	CDD:197706
		DUF1136	1922..1948	CDD:284093
		I-set	1958..2049	CDD:254352
		Ig	1985..2044	CDD:143165
		I-set	2089..2181	CDD:254352
		IGc2	2103..2171	CDD:197706
		DUF1136	2187..2213	CDD:284093
		I-set	2222..2314	CDD:254352
		IGc2	2236..2304	CDD:197706
		DUF1136	2320..2346	CDD:284093
		I-set	2356..2448	CDD:254352
		Ig	2384..2445	CDD:143165
		DUF1136	2454..2480	CDD:284093
		I-set	2488..2580	CDD:254352
		Ig	2516..2576	CDD:143165
		I-set	2622..2714	CDD:254352
		IGc2	2636..2704	CDD:197706
		I-set	2754..2844	CDD:254352
		Ig	2771..2840	CDD:143165
		IGc2	2908..2974	CDD:197706
		I-set	3029..3120	CDD:254352
		Ig	3057..3116	CDD:143165
		I-set	3130..3220	CDD:254352
		Ig	3148..3219	CDD:143165
		I-set	3263..3354	CDD:254352
		I-set	3401..3493	CDD:254352
		Ig	3429..3490	CDD:143165
		I-set	3539..3630	CDD:254352
		Ig	3556..3625	CDD:143165
		I-set	3676..3767	CDD:254352
IGc2	3690..3758	CDD:197706
I-set	3811..3900	CDD:254352
Ig	3828..3899	CDD:143165
I-set	3954..4046	CDD:254352
Ig	3963..4042	CDD:299845
I-set	4092..4180	CDD:254352
Ig	4102..4172	CDD:299845
I-set	4394..4483	CDD:254352
Ig	4411..4480	CDD:143165
I-set	4497..4581	CDD:254352
Ig	4519..4580	CDD:143165
I-set	4604..4693	CDD:254352
Ig	4621..4691	CDD:299845
I-set	4702..4792	CDD:254352
Ig	4702..4791	CDD:299845
COG4372	4996..>5260	CDD:226809
I-set	6536..6622	CDD:254352
Ig	6554..6622	CDD:143165
Ig	6654..6725	CDD:143165
I-set	6743..6829	CDD:254352
Ig	6760..6829	CDD:299845
I-set	6841..6928	CDD:254352
Ig	6858..6927	CDD:143165
I-set	6942..7033	CDD:254352
IGc2	6957..7023	CDD:197706
I-set	7066..7157	CDD:254352
Ig	7084..7153	CDD:143165
IGc2	7224..7289	CDD:197706
Ehrlichia_rpt	14571..15030	CDD:118064
SH3_p47phox_like	16753..16807	CDD:212790
I-set	16841..16931	CDD:254352
Ig	16858..16931	CDD:299845
I-set	16965..17060	CDD:254352
IGc2	16978..17050	CDD:197706
I-set	17068..17152	CDD:254352
Ig_2	17078..17152	CDD:290606
IG_like	17170..17253	CDD:214653
Ig	17180..17250	CDD:143165
I-set	17260..17342	CDD:254352
IGc2	17274..17331	CDD:197706
I-set	17347..17432	CDD:254352
IGc2	17367..17423	CDD:197706
I-set	17437..17521	CDD:254352
Ig	<17468..17521	CDD:299845
I-set	17528..17611	CDD:254352
Ig	17553..17602	CDD:143165
I-set	17618..17708	CDD:254352
Ig	17635..17708	CDD:299845
FN3	17712..17791	CDD:238020
I-set	17813..17898	CDD:254352
Ig	17830..17894	CDD:143165
Ig	17922..17994	CDD:299845
FN3	17998..18090	CDD:238020
FN3	18098..18189	CDD:238020
FN3	18207..18298	CDD:238020
FN3	18307..18398	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810