Protein Alignment PTK7 and CG31183

DIOPT Version :9

• Sequence 1: NP_001257327.1
• Gene: PTK7 / 5754
• HGNCID: 9618
• Length: 1078
• Species: Homo sapiens
• Sequence 2: NP_001287342.1
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Alignment Length: 1004
• Identity: 184/1004 - (18%)
• Similarity: 330/1004 - (32%)
• Gaps: 329/1004 - (32%)

Human   254 CQFSAQPPPSLQWLFEDE------------------TPITNRSR----------------PPH-- 282
            |...|...||..|.::.|                  ||.|..|.                |.|
  Fly    15 CLLQAHLFPSAAWFYDAESVGGVASIGVGSDEHSFKTPETKNSHKSQSTELVQHFPSLPMPDHRR 79

Human   283 --LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGS 345
              .||..||.   .||..|...|..  .||     .|.::....|.:..::.|.      |..||
  Fly    80 LGARRQLVFV---ALLPSVESDNKN--DCI-----MPKVLPVLELAIRHVQRMG------FVGGS 128

Human   346 EERVTCLP----------PKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCH 400
            ...:..:.          |.|..|....|       |....|:....|.|||.|:.. |.|:...
  Fly   129 HFDIQLISRDTFCSSKYGPIGFFEIYTQW-------PEVNAVFGLPCEYVLAPISRY-ADVWQVP 185

Human   401 AANLAGQRRQDVNITVATVPSWLKKPQD----SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLIS 461
            .....|..::           :.||.:.    ::|:..:...|..:.:|... :..|.|..::..
  Fly   186 VLTTGGNAKE-----------FNKKSESYSTLTRLKGAQVNNLGNVVRAILN-SFNWTRTALIYQ 238

Human   462 EDSRFEVFKNGTLRINSV---------------EVYD-----GTWYRCMSSTPAGSIEAQARVQV 506
            .:       |..::.|||               .||.     .||.:...:....::..|:|:.:
  Fly   239 NE-------NAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVI 296

Human   507 LEKLKFTPPPQPQQCMEFDKEATVPCSAT---------------------GREKPTIKWERADG- 549
            :    ...|...:|.|...:|..:..|..                     .:....:..|||..
  Fly   297 M----CADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKA 357

Human   550 -----SSLPEWVTDNAGTLHFARVTRD------DAGNYTCIASNGPQGQIRAHVQLTVAVFIT-- 601
                 :..|:...||    .:.||:.:      :..||| .:.|.|           ::.|:|
  Fly   358 YTAMLTVTPKQPNDN----EYTRVSNEIKAIAAEKYNYT-FSDNEP-----------ISAFVTSF 406

Human   602 --------------FKVEPERTT---------------VYQGHTALLQCEAQGDPKPLIQWKGKD 637
                          .:.:|...|               .:.|.|..:..:|.||......
  Fly   407 FDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYS----- 466

Human   638 RILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPV-------- 694
             :||   :.|....|:..:..:|:....::.:....||:     ..|||   .|:|:
  Fly   467 -LLD---MNPTTGRFEIVAHFLHNRLEFEANKEIHWAGD-----REEAP---PDRPICGYDGALC 519

Human   695 PEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEME---- 755
            |:     .|.|.|.::..:       :..::.|:.:.|:...|......:......:..:|
  Fly   520 PD-----NSLPGYAILSIV-------LGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMF 572

Human   756 --CLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFG-- 816
              ....|  ..|...:.:::...||.:.....:.|     .|:..|     .|:....||:..
  Fly   573 RDAAERG--LRGSFHSLVKQSSQLTLMSEDMVSIN-----GDRQIF-----IPVGMFRKSKVAIK 625

Human   817 EVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYM 881
            .|.:...|||         |.:||.           .||:....|.|.::|:..|.|.:....::
  Fly   626 PVEVDNVQGL---------LTRSLM-----------LELKRMKDLQHDHLVKFYGACLDQRRSFL 670

Human   882 VLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHL-SNNRFVHKDLAARNCL 945
            :.||...|.|:..|     ::|:.:   |....:::|...:..||:.| |::...|.:|.:.||:
  Fly   671 LTEYCPKGSLQDIL-----ENEQFQ---LDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCV 727

Human   946 VSAQRQVKVSALGLSK------DV------YNSEYYHFRQAWVPLRWMSPEAIL-------EGDF 991
            |.::..:|::..||..      |:      .||..|     |..|.|.:||.:.       ||
  Fly   728 VDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAY-----WSKLLWTAPELLRVEHNRPPEG-- 785

Human   992 STKSDVWAFGVLMWEVFTH------GEMPHGGQADDEVLADLQAG----KARLP-----QPEG-C 1040
            :.|.||:|||:::.|:.|.      |...:  :...:.:.:|..|    :.:.|     :|.| .
  Fly   786 TQKGDVYAFGIIVHEITTRQGPFYLGRCAY--EKSPQEIIELVKGYNPHRMQKPFRPELEPNGDT 848

Human  1041 PSKLYRLMQRCWALSPKDRPSFSEIASAL 1069
            .:.:..:::||||..|.:||.|:.:.|.:
  Fly   849 KADINGIIRRCWAEDPAERPDFNTLKSMI 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653	20/92 (22%)
		Ig	250..310	CDD:143165	20/93 (22%)
		IG	348..416	CDD:214652	14/77 (18%)
		IGc2	348..406	CDD:197706	13/67 (19%)
		I-set	420..506	CDD:254352	17/109 (16%)
		Ig	422..506	CDD:299845	17/107 (16%)
		I-set	511..596	CDD:254352	18/117 (15%)
		IGc2	528..582	CDD:197706	12/86 (14%)
		IG_like	606..689	CDD:214653	17/97 (18%)
		IGc2	613..677	CDD:197706	12/63 (19%)
		PTK_CCK4	798..1071	CDD:133178	72/310 (23%)
		STYKc	809..1069	CDD:214568	70/297 (24%)
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	76/481 (16%)
		ANF_receptor	108..473	CDD:279440	65/426 (15%)
		PK_GC-A_B	589..883	CDD:270944	76/336 (23%)
		Pkinase_Tyr	613..877	CDD:285015	71/300 (24%)
		HNOBA	<893..938	CDD:285003
		CYCc	917..1108	CDD:214485
		Guanylate_cyc	944..1130	CDD:278633

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910