Protein Alignment PTK7 and FER

DIOPT Version :9

• Sequence 1: NP_001257327.1
• Gene: PTK7 / 5754
• HGNCID: 9618
• Length: 1078
• Species: Homo sapiens
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1010
• Identity: 223/1010 - (22%)
• Similarity: 377/1010 - (37%)
• Gaps: 276/1010 - (27%)

Human   180 GQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVV 244
            |:..|.    :|..|.:||.|        ...|..|:....|..:.|:...|..|....|..
  Fly   453 GRGRHF----KRKSTPQPATP--------MTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSP--- 502

Human   245 ARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRC 309
            ||||....|   ..:...|:.:|.|:..  |:.:.||.|.|        |..||..      ..|
  Fly   503 ARYEPITNH---RLRQAASVHYLGEEIA--TSSTNPPDLTR--------LRRTQCS------MLC 548

Human   310 IGQGQRGPPIILEATLHLAEI--------------EDMPLFEPRVFTAGSEERVTCLPPKGLPEP 360
            :|:.:.  |::|.:...|.::              .|:.|.:.:..:...|.:...:.||
  Fly   549 LGEDEE--PVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPK----- 606

Human   361 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSW--- 422
                 ...:|:..:....|...:..|..|.|.:..:.......|  |...|||...:...:.
  Fly   607 -----KEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTL--QPSDDVNAIESAEENHIQT 664

Human   423 --LKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGT 485
              |.|..|||.:.......:|   .:.|.|....:..:..|:.|...:|.|
  Fly   665 RKLAKDPDSQTKRSSSSSSEC---RSSKDTSHSKKRSLSFSQKSISNIFSN-------------- 712

Human   486 WYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCS---ATGREKPTIKWERA 547
             .:..|.:|   :....:..:|.:             |.|.:.|.|..   ::|.:.||   ..:
  Fly   713 -LKEFSKSP---LVRMGKNHILNE-------------EQDAKRTQPSQHHHSSGSDCPT---NSS 757

Human   548 DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIAS--------------NGPQGQIRAHV----QL 594
            ..||     .:|....:.:..:...|...|.|.|              :....:::..|    :.
  Fly   758 SSSS-----NNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKK 817

Human   595 TVAVFITF----------------------KVEPERTT--------VYQ--GHTA---LLQCEAQ 624
            :.|:..||                      ::.|.::.        |.|  |..|   ...|...
  Fly   818 SKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPA 882

Human   625 GDP--KPLIQWKG-KDRILDPTKLGPRMHIFQ--NGSL-------VIHDVAPEDSG--------- 668
            |..  ||.:|..| ||            |.|:  :|.|       :.:|...|||.
  Fly   883 GQKPVKPSVQISGHKD------------HPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKD 935

Human   669 RYTCIAGNSCNIK-HTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMF 732
            ...|:...:.:|. .|..|||       ||....|..|..::::.:.......|...|
  Fly   936 HCYCVPSLAASISLSTNRPLY-------EEEWFHGVLPREEVVRLLNNDGDFLVRETI------- 986

Human   733 YCKKRCKAKRLQKQPEGEEPEM---ECLNG-----------GPLQ-NGQPSAEIQE--------E 774
                           ..||.::   .|.||           |..: .|.|.|.|||        |
  Fly   987 ---------------RNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSE 1036

Human   775 VALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKS 839
            :.:| :.||  |..:|....::.......:..:..:|:..||:|:.||.:..:..||     ||:
  Fly  1037 LPVT-VKSG--AILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVA-----VKT 1093

Human   840 LQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDE 903
            .: :..::|:..|.:|..:..:.:|.|:|:|:|:|.:.:|..:|:|.|..|.|..:||
  Fly  1094 CRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR------- 1151

Human   904 KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 968
             ..|..|:|:|::.:|...|.||.:|.:...:|:|||||||||..:..||:|..|:|::  ..||
  Fly  1152 -KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEY 1213

Human   969 Y---HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAG 1030
            .   ..:|  :|::|.:|||:..|.:::..|||::|:||||:|:.|:.|:.|..:......:..|
  Fly  1214 IVSDGMKQ--IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTG 1276

Human  1031 KARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1065
             .|:|.|:..|.::||||.:|||...:.||.|.||
  Fly  1277 -YRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237	11/49 (22%)
		IG_like	239..>309	CDD:214653	17/69 (25%)
		Ig	250..310	CDD:143165	12/59 (20%)
		IG	348..416	CDD:214652	12/67 (18%)
		IGc2	348..406	CDD:197706	8/57 (14%)
		I-set	420..506	CDD:254352	14/90 (16%)
		Ig	422..506	CDD:299845	14/88 (16%)
		I-set	511..596	CDD:254352	15/105 (14%)
		IGc2	528..582	CDD:197706	12/70 (17%)
		IG_like	606..689	CDD:214653	26/117 (22%)
		IGc2	613..677	CDD:197706	20/89 (22%)
		PTK_CCK4	798..1071	CDD:133178	89/272 (33%)
		STYKc	809..1069	CDD:214568	89/261 (34%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/114 (19%)
		TyrKc	1063..1311	CDD:197581	89/266 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/262 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910