DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and Dscam2

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	196/738 - (26%)
Similarity:	279/738 - (37%)	Gaps:	135/738 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    30 GRVGPGT--QTAIVFIKQPSSQDALQGRRALLRCEVE-APGPVHVYWLLDGA---PVQDTERRFA 88
            |.:.|..  .||.|.:    |||  :|  |:|.|..: .|.|.:.::..:||   ||....|...
  Fly   234 GIISPSVVEHTAHVQV----SQD--EG--AVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRL 290

Human    89 QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQT- 152
            .|..|:..||.. :|||.::|.| .:|.||      ||..::...|.|:       :.||.|..
  Fly   291 LGPILAIEAVTG-EDSGVYKCTA-GNVGGE------ASAELRLTVATPI-------QVEISPNVL 340

Human   153 ------QVTLRCHIDGHPRP----TYQWFRDGTPL-SDGQSNHTVSSKERNLTLRPAGPEHSGLY 206
                  ....||.:..:..|    ...|::||..| |.|:...|       |.:.....|:.|:|
  Fly   341 SVHMGGTAEFRCLVTSNGSPVGMQNILWYKDGRQLPSSGRVEDT-------LVVPRVSRENRGMY 398

Human   207 SCCAHSAFG---QACSSQNFTLSIADE------SFARVVLAPQDVVVARYEEAMFHCQFSAQPPP 262
            .|......|   ||.:.    |.:.|.      ||....|.|...|..:       |..:..|.|
  Fly   399 QCVVRRPEGDTFQATAE----LQLGDAPPVLLYSFIEQTLQPGPAVSLK-------CSAAGNPTP 452

Human   263 SLQWLFEDETPITNRSRPPHLRRATVFANGSLL----LTQVRPRNAGIYRCIGQGQRGPPIILEA 323
            .:.|.. |..|:.:..|  .:....:..:|.::    ::.|...:.|.|.||.:.:.|      .
  Fly   453 QISWTL-DGFPLPSNGR--FMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAG------R 508

Human   324 TLHLA--EIEDMPLFE--PRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLP--THGRVYQKGH 382
            ..|.|  .|..:|...  |:|.....|......|..|.|...:.||..|..||  ...||...|.
  Fly   509 VQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQRVQPDGS 573

Human   383 ELVLANIAESDAGVYTCHAANLAG-QRRQDVNITVATVPSWLKKPQDS--QLEEGKPGYLDCLTQ 444
            ..:......||:|||||.|.|..| ..|:...:|| .||..|...|.:  ||..|....|.|...
  Fly   574 LTISPVQKNSDSGVYTCWARNKQGHSARRSGEVTV-IVPPKLSPFQTNILQLNMGDRASLTCSVV 637

Human   445 ATPKP-TVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTW------YRCMSSTPAGSIE-AQ 501
            ....| |:.|.::...|.......|  ....:.||:.|.:...      |.|:....|..:| :|
  Fly   638 KGDLPLTINWRKDGRPIDPTQHMSV--KQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQ 700

Human   502 ARVQVLEKLKFTPPP----QPQQC-MEFDKEATVPCSATGREKPTIKWERADGSSLPEW------ 555
            |       |....||    :|... :|.::...:.|.|.|...|:|.|::|.||...|:
  Fly   701 A-------LLVNVPPRWIVEPVDANVERNRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRER 758

Human   556 ----VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHT 616
                :..| |:|....|..|..|.|.|.|:||....|...:||.|.....|........|.:|.|
  Fly   759 PFTKLLGN-GSLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDT 822

Human   617 ALLQCEAQGDPKPL-IQW--KGKDRILDPT---KLGPRMHIFQNG---SLVIHDVAPEDSGRYTC 672
            |||||...|| ||: |.|  .||: .|:|:   |:..:.....:|   .|.|..|...|||.|.|
  Fly   823 ALLQCAVSGD-KPINIVWMRSGKN-TLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFC 885

Human   673 IAGNSCNIKHTEAPLYVVDKPVP 695
            .|.|..........|.|.:.|:|
  Fly   886 RASNLYGNDQQLVQLQVQEPPLP 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653	26/77 (34%)
		IGc2	53..113	CDD:197706	20/63 (32%)
		Ig2_PTK7	154..230	CDD:143237	19/83 (23%)
		IG_like	239..>309	CDD:214653	13/73 (18%)
		Ig	250..310	CDD:143165	11/63 (17%)
		IG	348..416	CDD:214652	22/70 (31%)
		IGc2	348..406	CDD:197706	20/59 (34%)
		I-set	420..506	CDD:254352	22/95 (23%)
		Ig	422..506	CDD:299845	21/93 (23%)
		I-set	511..596	CDD:254352	28/99 (28%)
		IGc2	528..582	CDD:197706	19/63 (30%)
		IG_like	606..689	CDD:214653	31/91 (34%)
		IGc2	613..677	CDD:197706	28/72 (39%)
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	32/104 (31%)
		Ig	247..327	CDD:299845	29/95 (31%)
		I-set	332..418	CDD:254352	22/96 (23%)
		IGc2	344..407	CDD:197706	15/69 (22%)
		IG_like	432..517	CDD:214653	19/100 (19%)
		IGc2	436..507	CDD:197706	15/80 (19%)
		I-set	521..610	CDD:254352	28/89 (31%)
		IGc2	533..597	CDD:197706	21/63 (33%)
		Ig	630..699	CDD:143165	14/70 (20%)
		IG_like	714..802	CDD:214653	26/88 (30%)
		Ig	725..802	CDD:299845	24/77 (31%)
		Ig	823..894	CDD:143165	27/72 (38%)
		FN3	906..1006	CDD:238020	2/3 (67%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910