DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTK7 and Egfr

DIOPT Version :9

Sequence 1:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:1148 Identity:234/1148 - (20%)
Similarity:385/1148 - (33%) Gaps:405/1148 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   158 CHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQA---CS 219
            ||:     .|.||....:..:|...|:..::.||         |....:..|.|..:|:.   | 
  Fly   228 CHM-----RTIQWSEIVSNGTDAYYNYDFTAPER---------ECPKCHESCTHGCWGEGPKNC- 277

Human   220 SQNFTLSIADESFARVVLAPQDVVVARY-----EEAMFHCQFSAQPPPSLQWL----FEDETPIT 275
                      :.|:::..:||......|     |.....|......|.....:    |.|| .:.
  Fly   278 ----------QKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDE-GVC 331

Human   276 NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHL-----AEIEDMPL 335
            ....|| :|:    .|.:..:.:..|.....|        |...:.|...||     |.:...| 
  Fly   332 KEECPP-MRK----YNPTTYVLETNPEGKYAY--------GATCVKECPGHLLRDNGACVRSCP- 382

Human   336 FEPRVFTAGSEERVTCLPPKG-LPE--PSVWWEHAG--------------VRL------------ 371
             :.::...|.     |:|..| .|:  |.|...|||              :|:            
  Fly   383 -QDKMDKGGE-----CVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVY 441

Human   372 -------------------------------------------------PTHGRVYQKGHELVLA 387
                                                             ..|||...   |.:.|
  Fly   442 ANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLM---ESMFA 503

Human   388 NIAESDAGVYTCHAANL----AG----QRRQDVNITVATV--PSWLKKPQDSQLEEGKPGYLDCL 442
            .:|...:.:|:....||    :|    |..:|: ..|:.:  |:..|:|:..             
  Fly   504 ALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDL-CYVSNIRWPAIQKEPEQK------------- 554

Human   443 TQATPKPTVVWYRNQMLISEDSRFEVF-KNGTL---RINSVEVYDGTW----------------- 486
                     ||      ::|:.|.::. ||||:   :.|.    ||.|                 
  Fly   555 ---------VW------VNENLRADLCEKNGTICSDQCNE----DGCWGAGTDQCLTCKNFNFNG 600

Human   487 ------------YR------------CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCME---- 523
                        |:            |.:...||:...|..|.|.:         .|.|:.    
  Fly   601 TCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRD---------GQHCVSECPK 656

Human   524 ---FDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAG-----TLHFARVTRDDAGNYTCIA 580
               .|:.....|.||           .||.:.|:   |..|     |.:.| :..:||....|:.
  Fly   657 NKYNDRGVCRECHAT-----------CDGCTGPK---DTIGIGACTTCNLA-IINNDATVKRCLL 706

Human   581 SNG--PQG--------QIRAHVQLTVAVFITFKVEP--ERTTVYQGHTALL----------QCEA 623
            .:.  |.|        |.:..::......:..|..|  |..|.|..|..:.          |||.
  Fly   707 KDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCET 771

Human   624 Q----------------------GDPKPLIQWKGKD--------RILDPTKLGPRMHIFQNGSLV 658
            :                      |...|     |.|        ::.|..:.||.:         
  Fly   772 ECPADHYTDEEQRECFQCHPECNGCTGP-----GADDCKSCRNFKLFDANETGPYV--------- 822

Human   659 IHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP---GSPPPYKMIQTIGLSV--- 717
                   :|..:.|.:.....::|.......:         ||   .|||....| |..|.|   
  Fly   823 -------NSTMFNCTSKCPLEMRHVNYQYTAI---------GPYCAASPPRSSKI-TANLDVNMI 870

Human   718 ----GAAVAYIIAVLGLMFY-CKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVAL 777
                ||.:...|.:|.::.| |:::.|||:       |..:|.....|        .|..|.:..
  Fly   871 FIITGAVLVPTICILCVVTYICRQKQKAKK-------ETVKMTMALSG--------CEDSEPLRP 920

Human   778 TSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEG--VAETLVLVKSL 840
            :::|   |...|.....|      :.|:....||...||.|:  |...:.||  |...:.:.:.|
  Fly   921 SNIG---ANLCKLRIVKD------AELRKGGVLGMGAFGRVY--KGVWVPEGENVKIPVAIKELL 974

Human   841 QSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKL 905
            :|...:...:|.||..:...:.|.|:::||.:|..:: ..::.:.:.||.|..::|.::.|    
  Fly   975 KSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDK---- 1034

Human   906 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH 970
                :.:|..:...||:|.||.:|...|.||:||||||.||.....||::..||:| :.:|:...
  Fly  1035 ----IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAK-LLSSDSNE 1094

Human   971 FRQAW--VPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG-QADDEVLADLQAGKA 1032
            ::.|.  :|::|::.|.|....|::|||||||||.:||:.|.|:.||.. .|.|  :.||.....
  Fly  1095 YKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKD--IPDLIEVGL 1157

Human  1033 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1075
            :|.|||.|...:|..:..||.|....||:|.::.:...:...|
  Fly  1158 KLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARD 1200

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK7NP_001257327.1 IG_like 46..120 CDD:214653
IGc2 53..113 CDD:197706
Ig2_PTK7 154..230 CDD:143237 14/74 (19%)
IG_like 239..>309 CDD:214653 15/78 (19%)
Ig 250..310 CDD:143165 11/63 (17%)
IG 348..416 CDD:214652 22/153 (14%)
IGc2 348..406 CDD:197706 19/139 (14%)
I-set 420..506 CDD:254352 21/130 (16%)
Ig 422..506 CDD:299845 20/128 (16%)
I-set 511..596 CDD:254352 19/106 (18%)
IGc2 528..582 CDD:197706 13/58 (22%)
IG_like 606..689 CDD:214653 18/124 (15%)
IGc2 613..677 CDD:197706 13/103 (13%)
PTK_CCK4 798..1071 CDD:133178 86/277 (31%)
STYKc 809..1069 CDD:214568 85/264 (32%)
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 15/131 (11%)
GF_recep_IV 572..684 CDD:291509 21/138 (15%)
FU 573..>606 CDD:238021 4/36 (11%)
FU 617..659 CDD:214589 8/50 (16%)
FU 662..716 CDD:214589 15/68 (22%)
FU 739..786 CDD:238021 9/46 (20%)
FU 784..834 CDD:214589 9/70 (13%)
PTKc_EGFR_like 930..1208 CDD:270648 88/291 (30%)
STYKc 938..1194 CDD:214568 86/269 (32%)
Recep_L_domain 128..239 CDD:279382 5/15 (33%)
Furin-like 253..401 CDD:279142 33/188 (18%)
FU 255..292 CDD:214589 10/56 (18%)
FU 302..345 CDD:238021 9/48 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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