DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and otk

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster

Alignment Length:	1138	Identity:	325/1138 - (28%)
Similarity:	501/1138 - (44%)	Gaps:	250/1138 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    42 FIKQPSSQDALQGRRALLRCE-VEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 105
            |.:.|.||..::.......|| .::...:|..||.:|..:...:|....||:|...||.|.:|.|
  Fly    27 FQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVG 91

Human   106 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHP---RP- 166
            .:.|:|.:..:|....|..|..::.::|:..|.|..       ..:.::.|:||::|..   .|
  Fly    92 NYVCIATNLASGAREASPPAKLSVIYLESASVQLLG-------SNRNELLLKCHVEGASGDLEPL 149

Human   167 TYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADES 231
            ..:|:|:...||..::   |...:..|.:|..|.|..|||.|.|.:|.|:..|.|.:....:.:.
  Fly   150 EIEWYRNSEKLSTWKN---VQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKC 211

Human   232 FARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLL 296
            ..|:.....:.::..:::..|.|:........|:.|         .:.|..||
  Fly   212 LPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEAL---------PAAPEDLR------------ 255

Human   297 TQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPS 361
                         |.||..|..||.|                     |....:|||  ..||:
  Fly   256 -------------IVQGPIGQSIIKE---------------------GEPTALTCL--YELPD-- 282

Human   362 VWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKP 426
               |....|:...   ::|..:|:              ....|.|.         |.:|.
  Fly   283 ---ELKNQRIQLR---WRKDGKLL--------------RQVELGGS---------APIPG----- 313

Human   427 QDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFK-NGTLRINSVEVYDGTWYRCM 490
              ...:.||                     ..|:.||:|..:.| ||||...|:...|...|:|.
  Fly   314 --HSFDSGK---------------------DALLREDARLVLHKQNGTLSFASIIASDAGQYQCQ 355

Human   491 SSTPAGSIEAQARV-------QVLEKLKFTPPPQPQQCMEFDK-EATVPCSATGREKPTIKWER- 546
            .     .:||.|.:       :|:|:|||.|.|..:. :|.|. .|.|.|.|.|...|.::|.|
  Fly   356 L-----QLEAHAPINSSPGILEVIEQLKFVPQPTSKN-LELDAVVAKVHCKAQGTPTPQVQWVRD 414

Human   547 ADGSSLPEWV-TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEP--ER 608
            .:.::||:.| .|..|||.|..|..:..|||||:|:|. ||||.|.|.:.|.|...|.|.|  ..
  Fly   415 GENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNS-QGQINATVAINVVVTPKFSVPPVGPI 478

Human   609 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLG-PRMHIFQNGSLVIHDVAPEDSGRYTC 672
            .|..|| |.::.|:|.|||||.|||....:.|...... .|....:||:|.|.:|..||.|.|.|
  Fly   479 ETSEQG-TVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGC 542

Human   673 IAGNSCNIKHTEAPLYVV---DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYC 734
            ..|||..:|..:..|.|.   |...||||.|.|    :.:.:.:.:::..|:|||:.|:|||.:|
  Fly   543 TIGNSAGLKREDVQLVVKTTGDGFAPEESGGDG----FLVTRAVLITMTVALAYIVLVVGLMLWC 603

Human   735 KKRCKAKRLQ------KQPEGEEPEM----------ECL----NGGPLQNGQPSAEIQEEVALTS 779
            :.|.:|::.:      |:..|::|::          .||    ||......:.|.:.|:... |:
  Fly   604 RYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDD-TA 667

Human   780 LGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG------------------- 825
            ......|:.|.....:::..|||.|..:..:|:.|||:||:.|.:.
  Fly   668 CSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSN 732

Human   826 ------------------------------LEE------------GVAETLVLVKSLQS-KDEQQ 847
                                          :||            |: |.|||||:|.. ||||.
  Fly   733 SENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGL-EQLVLVKALNKVKDEQA 796

Human   848 QLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL-----RISKSKDEKLKS 907
            ..:|||:|::...::|..||||.|||||.:||||||||.|.|||||||     :::.:.......
  Fly   797 CQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSP 861

Human   908 QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR 972
            .||:|.|.:|:..|:|.||:.:...||.|:|||.|||::|::..||||...|.||.|:.||:..|
  Fly   862 PPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHR 926

Human   973 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHG-EMPHGGQADDEVLADLQAGKARLPQ 1036
            ...:|:||::||.|.|.:::||||::|:||::||:|... ::||....:::|:...|||......
  Fly   927 NTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSV 991

Human  1037 PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1069
            .|..|..|..::..||..:||:|||||::.:||
  Fly   992 AEATPDSLREILLSCWVSNPKERPSFSQLGAAL 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653	21/74 (28%)
		IGc2	53..113	CDD:197706	17/60 (28%)
		Ig2_PTK7	154..230	CDD:143237	23/79 (29%)
		IG_like	239..>309	CDD:214653	7/69 (10%)
		Ig	250..310	CDD:143165	7/59 (12%)
		IG	348..416	CDD:214652	11/67 (16%)
		IGc2	348..406	CDD:197706	10/57 (18%)
		I-set	420..506	CDD:254352	19/93 (20%)
		Ig	422..506	CDD:299845	18/91 (20%)
		I-set	511..596	CDD:254352	36/87 (41%)
		IGc2	528..582	CDD:197706	23/55 (42%)
		IG_like	606..689	CDD:214653	32/85 (38%)
		IGc2	613..677	CDD:197706	26/64 (41%)
		PTK_CCK4	798..1071	CDD:133178	122/340 (36%)
		STYKc	809..1069	CDD:214568	116/327 (35%)
otk	NP_523705.2	I-set	26..115	CDD:254352	24/87 (28%)
		Ig	31..115	CDD:299845	23/83 (28%)
		IGc2	133..195	CDD:197706	20/64 (31%)
		Ig	268..373	CDD:299845	33/191 (17%)
		Ig	395..460	CDD:143165	29/65 (45%)
		I-set	468..559	CDD:254352	34/91 (37%)
		IGc2	484..549	CDD:197706	27/65 (42%)
		PTK_CCK4	686..1026	CDD:133178	122/340 (36%)
		STYKc	692..1020	CDD:214568	117/328 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147252
Domainoid	1	1.000	213	1.000	Domainoid score	I2763
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43672
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2306
Isobase	1	0.950	-	0	Normalized mean entropy	S5350
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245153at33208
OrthoFinder	1	1.000	-	-		FOG0007317
OrthoInspector	1	1.000	-	-		otm41120
orthoMCL	1	0.900	-	-		OOG6_109217
Panther	1	1.100	-	-	LDO	PTHR26391
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4731
SonicParanoid	1	1.000	-	-		X6206
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740