DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK7 and dpr19

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	367	Identity:	77/367 - (20%)
Similarity:	121/367 - (32%)	Gaps:	108/367 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   292 GSLLLTQVRPRNAGIYRCIGQGQRGPPIIL--------EATLHLAEIEDMPLFEPRVFTAGSEER 348
            |:.|.:|...:|.  .|.|  .|:|...||        .||:.....:|..|....:.|..|::|
  Fly    35 GNTLQSQFNTKNN--TRVI--AQKGGLAILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKR 95

Human   349 VTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGH-ELVLANIAESDAGVYTCHAANLAGQRRQDV 412
            .                     |..|.|  ..|| .|.:..:.|.|.|.|.|..:....|... :
  Fly    96 F---------------------LVEHTR--HMGHWSLRIKAVREEDRGFYECQLSIYPTQSIV-I 136

Human   413 NITVATVPSWLKKPQDSQLEEGKPGYLDC-LTQATPKPT-VVWYRNQMLISEDSRFEVFKNGTLR 475
            .:.:....:.:....:..::|.....|:| |.:||..|. |.||.:..:|:.||:      |...
  Fly   137 ELKIVEAVAEISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYDSQ------GGFV 195

Human   476 INSV---EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATG- 536
            :.|:   ....|.:||   |:||..                            ..||:|..::.
  Fly   196 VTSIGQSNPQSGQFYR---SSPANK----------------------------SRATMPMESSNG 229

Human   537 ------REKPTIKWERADGSSLPEWVTD----------NAGTLHFARVTRDDAGNYTCIASNGPQ 585
                  .....||...|:..|...::|.          :...|...:|....||||||..||...
  Fly   230 VLNSLLGSSDAIKAPAANVPSSTPYMTQQHQSAYLLNPSVSVLTVKQVNFRHAGNYTCAPSNARP 294

Human   586 GQIRAHVQLTVAVFITFKVEPERTTVYQ-GHTALLQCEAQGD 626
            ..|..||           :..|:|...| .:.::|..|..|:
  Fly   295 ASITVHV-----------LRGEKTAAMQHANRSILDTETNGN 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653	4/16 (25%)
		Ig	250..310	CDD:143165	5/17 (29%)
		IG	348..416	CDD:214652	13/68 (19%)
		IGc2	348..406	CDD:197706	12/58 (21%)
		I-set	420..506	CDD:254352	21/90 (23%)
		Ig	422..506	CDD:299845	21/88 (24%)
		I-set	511..596	CDD:254352	21/101 (21%)
		IGc2	528..582	CDD:197706	16/70 (23%)
		IG_like	606..689	CDD:214653	6/22 (27%)
		IGc2	613..677	CDD:197706	4/15 (27%)
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	23/101 (23%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	20/92 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910