DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTK7 and Unc-89

DIOPT Version :9

Sequence 1:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens
Sequence 2:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster


Alignment Length:1350 Identity:267/1350 - (19%)
Similarity:447/1350 - (33%) Gaps:397/1350 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    30 GRVGPGTQTAIV-----FIKQPSSQDALQGRRALLRCEVE-APGPVHVYWLLDGAPV-------- 80
            ||.......|::     ||.||.||.....|....:..|. .|.|. :.|..|..|:        
  Fly  2098 GRAAVDFNLAVLVEKPTFIVQPESQSIHDYRPVSTKVLVHGVPLPT-IEWFKDDKPINYEAINKP 2161

Human    81 --------QDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPV 137
                    :||::...|..|:......|..|.|.:.|||.:::     ....|.|.:..:...|.
  Fly  2162 GKDKLYAKEDTKKGTDQIESVLDIKSFRENDVGAYTCVATNEI-----GVTKAPFKLAMLSLAPS 2221

Human   138 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGP 200
            .:|...:..::.....:.|.|.:||.|.||.||.:||..:...:|....::.:.  .|.:....|
  Fly  2222 FVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQP 2286

Human   201 EHSGLYSCCAHSAFGQ---ACSSQNFTLSIADESFARVVLAP---QDVVVARYEEAMFHCQFSAQ 259
            ..||.|.....:..|:   .|:     :::..|......|.|   |.|||.  |......|.:..
  Fly  2287 NDSGAYKLIISNPHGEKVALCA-----VAVKPEEMQPKFLKPITSQTVVVG--EPLKLEAQVTGF 2344

Human   260 PPPSLQWLFED-----ETPITNRSRPPHLRRATVFANG--SLLLTQVRPRNAGIYRCIGQGQRGP 317
            |.|.::| ::|     .:|..|....|         ||  .|::...:|.:||:|:|: ...:|.
  Fly  2345 PAPEVKW-YKDGMLLRPSPEINFINSP---------NGQIGLIIDAAQPLDAGVYKCL-IANKGG 2398

Human   318 PIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK------GLPEPSVWWEHAGVRL---PT 373
            .|...:.:.:...|..|:|...:..|.|.|.   .|.|      |.|:|.:.|.|.|..:   .:
  Fly  2399 EIEGVSKVEIVPKESKPVFVAELQDASSIEG---FPVKMDIKVVGNPKPKLQWFHNGHEIKPDAS 2460

Human   374 HGRVYQ---KGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---------TVPSWLKKP 426
            |..:.:   ....|::...|..|:|:|...|.|..|.......:.||         ..|.::...
  Fly  2461 HIAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAPKADETATEEAPQFVSAL 2525

Human   427 QDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGT---LRINSVEVYDGTWYR 488
            :|...:||:...|.....:.|.|.|:|.::.:.::.:.|..:..:|.   |.|...|..|...|.
  Fly  2526 RDVNADEGQELVLSAPFISNPMPEVIWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSGNYT 2590

Human   489 CMSSTPAGSIEAQARVQVLEKLK---FTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGS 550
            |:.:.|.|...:.....|.:..|   ||.....|| ..|...|.:|.:.:|...|.::|...| .
  Fly  2591 CLLANPLGEDSSACNANVRKVYKPPVFTQKISDQQ-QVFGNNAKIPVTVSGVPYPDLEWYFQD-K 2653

Human   551 SLP---EWVTDNAGTLHFARVT---RDDAGNYTCIASNG-----PQG------QIRAHVQLTVAV 598
            .:|   ::...|.|..|...|.   :.|.|.|.|||||.     .||      :|:.|.:....|
  Fly  2654 PIPKSEKYSIKNDGDHHMLIVNNCEKGDQGVYKCIASNREGKDITQGRLDIVNEIKKHSRSEPPV 2718

Human   599 FITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR--MHIFQNG--SLVI 659
            |:. |:..  ..:|:|..|.....|.|.|:|.::|...|:.|.|:   .|  :.|..||  .|.|
  Fly  2719 FLK-KIGD--CDIYEGMVAKFTACATGYPEPEVEWFKNDQKLFPS---DRFLIDIEPNGLLRLTI 2777

Human   660 HDVAPEDSGRYTCIAGN--SCNIKHTEAPLYVVD---KPVPEE------SEGPGSPPPY------ 707
            .:|...|.|||:|...|  ..:|.|.|.....:|   ||:.::      .:..|:|||.      
  Fly  2778 KNVTEYDVGRYSCRIFNPYGDDICHAELFYDSLDSQQKPLEDQYTDFKKYKKSGAPPPLSEGPII 2842

Human   708 -KMIQ---------TIGLSVGAAVAYIIAVLGL-----------MFYCKKRCKAKRLQK------ 745
             :|..         ::.|:....:.|.|.::.|           :..|  .|..:.|:.      
  Fly  2843 SRMTDRGLLLSWNPSVPLTPRYPITYQIEMMDLPEGDWRTLRTGVRSC--ACDIRNLEPFRDYRF 2905

Human   746 -----------------------------------------QPEG----------EEPEMECLNG 759
                                                     :||.          |.|..:.|..
  Fly  2906 RVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFPKDFDIERPPHDGLAQ 2970

Human   760 GP----------------------LQNGQPSAEIQ---EEVALTSLG--------SGPA------ 785
            .|                      ...|.|..::.   :::.:.|.|        :|.|      
  Fly  2971 APQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGGRFDQSYTRNGQATLFINK 3035

Human   786 ------------ATNKRHSTSDKMHF-----PRSSLQPITTL------GKSEF------------ 815
                        |||:......::..     ||...:|..|.      |:.|.            
  Fly  3036 MLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMARKNGRIEAKLVGIPLPEVHW 3100

Human   816 ----------------------------------GEVFLAKAQGLEEGVAETLVLVKSLQSKDE- 845
                                              |.::...|:.: .|...|.|.|...:::|: 
  Fly  3101 FKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISARNI-AGSISTSVTVHIEENEDQY 3164

Human   846 ------------QQQLDFR---------------------------------------------R 853
                        .:||.::                                             .
  Fly  3165 IYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGRPELRPFMLN 3229

Human   854 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVAL 918
            ||||....||.|::|............:::|....|:|        .:|..|:....:.:.....
  Fly  3230 ELEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGEL--------VRDNLLRRDYYTERDIAHY 3286

Human   919 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQ--VKVSALGLSKDVYNSEYYHFRQAWVPLRWM 981
            ..|...|:||:......|..|..::.|:|....  :|||..|||:.: |..........:| .::
  Fly  3287 IRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKI-NRHNLSTLDYGMP-EFV 3349

Human   982 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 1031
            |||.:.:...:...|:|..|::.: |...|..|..|..|.|.|..::.|:
  Fly  3350 SPEVVNKEGVNFSHDMWTVGLITY-VLLGGHNPFLGIDDRETLTKIREGR 3398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK7NP_001257327.1 IG_like 46..120 CDD:214653 20/90 (22%)
IGc2 53..113 CDD:197706 17/76 (22%)
Ig2_PTK7 154..230 CDD:143237 19/80 (24%)
IG_like 239..>309 CDD:214653 21/79 (27%)
Ig 250..310 CDD:143165 15/66 (23%)
IG 348..416 CDD:214652 17/79 (22%)
IGc2 348..406 CDD:197706 16/69 (23%)
I-set 420..506 CDD:254352 19/88 (22%)
Ig 422..506 CDD:299845 18/86 (21%)
I-set 511..596 CDD:254352 29/104 (28%)
IGc2 528..582 CDD:197706 17/59 (29%)
IG_like 606..689 CDD:214653 27/88 (31%)
IGc2 613..677 CDD:197706 23/69 (33%)
PTK_CCK4 798..1071 CDD:133178 58/350 (17%)
STYKc 809..1069 CDD:214568 55/334 (16%)
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254 2/9 (22%)
I-set 2113..2214 CDD:333254 25/106 (24%)
I-set 2220..2302 CDD:254352 19/81 (23%)
I-set 2318..2408 CDD:254352 25/102 (25%)
I-set 2415..2506 CDD:254352 22/93 (24%)
I-set 2519..2608 CDD:254352 19/88 (22%)
I-set 2615..2696 CDD:254352 24/82 (29%)
I-set 2717..2805 CDD:254352 29/93 (31%)
FN3 2834..2925 CDD:238020 10/92 (11%)
I-set <2996..3063 CDD:333254 9/66 (14%)
I-set 3067..3157 CDD:333254 12/90 (13%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 43/227 (19%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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