DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and robo3

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_608592.2	Gene:	robo3 / 33314	FlyBaseID:	FBgn0041097	Length:	1342	Species:	Drosophila melanogaster

Alignment Length:	842	Identity:	210/842 - (24%)
Similarity:	321/842 - (38%)	Gaps:	185/842 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   234 RVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQ 298
            |:|..|.|..|.|:|.|..:|:....|.|::|| ::|..|:   ...|...|.|:.|.|...|..
  Fly    24 RIVEHPIDTTVPRHEPATLNCKAEGSPTPTIQW-YKDGVPL---KILPGSHRITLPAGGLFFLKV 84

Human   299 VRPR---NAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPR--VFTAGSEERVTCLPPKGLP 358
            |..|   :||||.|..:.:.|......|||.:|.:.|....||:  ....|....:.|..|:|:|
  Fly    85 VNSRRETDAGIYWCEAKNELGVARSRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAAPRGIP 149

Human   359 EPSVWWEHAGVRLPTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDV-NITVAT 418
            ||:|.|:..|.:|...|    |:...|: |.:.:..::|.|.|.|.|.|..|.|...: .:.|..
  Fly   150 EPTVTWKKGGQKLDLEGSKRVRIVDGGN-LAIQDARQTDEGQYQCIAKNPVGVRESSLATLKVHV 213

Human   419 VPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYR-----NQMLISEDSRFEVFKNGTLRINS 478
            .|..::.|.|..:.||......|.....|.|.|:|.|     |..|    .|..|.::.:||:..
  Fly   214 KPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWLRTASGGNMPL----DRVSVLEDRSLRLER 274

Human   479 VEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIK 543
            |.:.|...|.|.:....|:|.|...:.|....||...| ..:.:|...:.:..|.|.|..||||.
  Fly   275 VTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRP-ASKSVELGADTSFECRAIGNPKPTIF 338

Human   544 WERADGSSLPEWVTDNAGTL------------------HFARVTRDDAGNYTCIASNGPQGQIRA 590
            |...:.|:|   :...|..|                  .|.|..:|..  ..|.|.| ....|.:
  Fly   339 WTIKNNSTL---IFPGAPPLDRFHSLNTEEGHSILTLTRFQRTDKDLV--ILCNAMN-EVASITS 397

Human   591 HVQLTV--------AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP 647
            .|||::        .:.|:   .|...|:.....|.|||:|.|.|.|.|.|. :|.|  |.:...
  Fly   398 RVQLSLDSQEDRPPPIIIS---GPVNQTLPIKSLATLQCKAIGLPSPTISWY-RDGI--PVQPSS 456

Human   648 RMHIFQNGSLVIHDV-APEDSGRYTCIAGNSCNIKHTEAPLYVVDKP---------VPEESEGPG 702
            :::|..:|.|:|.|: ..:|.|.|||:|.:... |.|.:....::.|         .||:::.|.
  Fly   457 KLNITTSGDLIISDLDRQQDQGLYTCVASSRAG-KSTWSGFLRIELPTNPNIKFYRAPEQTKCPS 520

Human   703 SPPPYKMIQTIGLSV----------GAAVAYIIAVLG--LMFYCKKRCK-----AKRLQKQPEGE 750
            :|...|::.....::          ||:     :.||  :..||..:.:     |.||      .
  Fly   521 APGQPKILNATASALTIVWPTSDKAGAS-----SFLGYSVEMYCTNQSRTWIPIASRL------S 574

Human   751 EP--EMECLNGGP-------LQNG---QPSAEIQEEVALTSL-----GSGPAAT----------- 787
            ||  .:|.|..|.       .:|.   .|.:.|.|.:....|     ||....|
  Fly   575 EPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVRDGSESTGTSQLLLSDVETL 639

Human   788 ------------NKRHSTSDKMHFPRSSLQPI-------TTLGKSEFGEV-FLAKAQGLEE---- 828
                        |...||:.::.:...|.|.|       ..|..||:..| .|.|.|||..
  Fly   640 LQANDVVELLEANASDSTTARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLNKGQGLSSCTVP 704

Human   829 GVAET----LVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG 889
            |:|:.    ..||...:|              :.||.:::..:|.|....||.|:.|  |.:...
  Fly   705 GLAKASTYEFFLVPFYKS--------------IVGKPSNSRRMRTLEDVPEAPPYGM--EAIQFN 753

Human   890 DLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHK----DLAARNCLVS 947
            ....||:       .|..||..|:..:.....|.:....:.|...:.|    |.||...|::
  Fly   754 RTSVFLK-------WLPPQPNRTRNGILTSYNVVVKGLDVHNTTRIFKNMTIDAAAPTLLLA 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653	25/72 (35%)
		Ig	250..310	CDD:143165	20/62 (32%)
		IG	348..416	CDD:214652	22/72 (31%)
		IGc2	348..406	CDD:197706	20/61 (33%)
		I-set	420..506	CDD:254352	24/90 (27%)
		Ig	422..506	CDD:299845	23/88 (26%)
		I-set	511..596	CDD:254352	26/102 (25%)
		IGc2	528..582	CDD:197706	17/71 (24%)
		IG_like	606..689	CDD:214653	28/83 (34%)
		IGc2	613..677	CDD:197706	24/64 (38%)
		PTK_CCK4	798..1071	CDD:133178	39/170 (23%)
		STYKc	809..1069	CDD:214568	36/152 (24%)
robo3	NP_608592.2	Ig	22..117	CDD:299845	32/96 (33%)
		I-set	23..116	CDD:254352	32/95 (34%)
		I-set	122..211	CDD:254352	25/89 (28%)
		Ig	125..211	CDD:299845	25/86 (29%)
		I-set	215..302	CDD:254352	24/90 (27%)
		Ig	232..302	CDD:299845	19/73 (26%)
		I-set	306..401	CDD:254352	24/101 (24%)
		Ig	320..411	CDD:299845	22/96 (23%)
		I-set	412..492	CDD:254352	28/86 (33%)
		IGc2	429..489	CDD:197706	24/62 (39%)
		FN3	519..612	CDD:238020	21/103 (20%)
		FN3	644..735	CDD:238020	22/104 (21%)
		fn3	743..832	CDD:278470	16/75 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910