DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK7 and dpr9

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001287332.1	Gene:	dpr9 / 2768670	FlyBaseID:	FBgn0038282	Length:	602	Species:	Drosophila melanogaster

Alignment Length:	287	Identity:	60/287 - (20%)
Similarity:	91/287 - (31%)	Gaps:	92/287 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   572 DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTT-------VYQGHTALLQCEAQGDPKP 629
            |:|.|.|..|..|  .:..::.|.|       |||....       :..|.|..|.|..|..|:|
  Fly   338 DSGIYECQVSTTP--HMSHYIHLNV-------VEPSTEIIGAPDLYIESGSTINLTCIIQNSPEP 393

Human   630 --LIQWKGKDRILDPTKL----GPR--MHIFQN------GSLVIHDVAPEDSGRYTCIAGNSCNI 680
              .|.|...:......::    .||  :.:..|      ..|:|....|.|||.|.|   |..|.
  Fly   394 PAYIFWNHNNAFPSHPQIINYDSPRGGVSVVTNKGDTTTSFLLIKSARPSDSGHYQC---NPSNA 455

Human   681 KHTEAPLYV-------VDKPVPEESEGPGSPPPYKMIQTIGLSVGAAV-------AYIIAVLGLM 731
            |.....::|       |.:.||..:...|:.....:..::.:.|...|       .:|.|:||..
  Fly   456 KPKSVTVHVLNGVSHSVSRGVPSSNAARGTSASSPLAHSLSVCVPVCVLLQLGACRWIAALLGAA 520

Human   732 FYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDK 796
            .......::.|   :..||.|            |.|             |..|.|.:.||..:..
  Fly   521 LATPPPLRSTR---RATGERP------------GSP-------------GCAPIACDMRHFLASV 557

Human   797 MHF-----------------PRSSLQP 806
            :.:                 ||..|:|
  Fly   558 LRWQWRWCWRWHWKGTQQQDPRHYLKP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653
		Ig	250..310	CDD:143165
		IG	348..416	CDD:214652
		IGc2	348..406	CDD:197706
		I-set	420..506	CDD:254352
		Ig	422..506	CDD:299845
		I-set	511..596	CDD:254352	7/23 (30%)
		IGc2	528..582	CDD:197706	4/9 (44%)
		IG_like	606..689	CDD:214653	24/103 (23%)
		IGc2	613..677	CDD:197706	20/77 (26%)
		PTK_CCK4	798..1071	CDD:133178	4/26 (15%)
		STYKc	809..1069	CDD:214568
dpr9	NP_001287332.1	Ig	263..361	CDD:299845	8/31 (26%)
		IG_like	263..360	CDD:214653	7/23 (30%)
		IG_like	371..464	CDD:214653	23/95 (24%)
		IGc2	377..456	CDD:197706	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910