DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK7 and trk-1

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_001360632.1	Gene:	trk-1 / 183575	WormBaseID:	WBGene00017039	Length:	842	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	167/713 - (23%)
Similarity:	277/713 - (38%)	Gaps:	176/713 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   474 LRINSVEV----YDGTWYRCMSSTPAGSIEAQARVQ--------VLEKLKFTPPPQPQQC----- 521
            :.||...:    :...|...:.:....|...|...|        :.||:  |.|...::|
Worm    96 IHINKCNLTSLPWQSIWTETLKTVDFSSCPIQCSCQNQWMRAKEIFEKI--TEPKSLRKCAWNCD 158

Human   522 ---------------------MEFDKEA---TVPCSATGREKPTIKWERADGSSLP----EWVTD 558
                                 :.||.:.   |:       :||...|.   .|..|    |.:.:
Worm   159 PGKMMFPGVIYSKNGDNVTVHVGFDDQVLNRTI-------DKPYFDWA---FSKHPHKHEEIIAE 213

Human   559 NAGTLHFARVTRDDAG-----NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGH--- 615
            ....|....:.|:|.|     .:.|:.....:.::||:..:.||.....:::.: ..|..|:
Worm   214 KGADLMITNLKREDMGVIGVKCWHCLDFLVGKIELRANYPVKVAFVDKTRLDTD-FLVVTGYPID 277

Human   616 ---TALLQCEAQGDPKPLIQWKGKDRILDPT---KLGPRMHIFQNGSLVI-HDVAPED--SG--R 669
               .|:.:.::.......: .:.||.|...:   ::..|...:|....|. .|.|..|  ||  |
Worm   278 NISMAITKMQSNYSETNFV-GREKDAIFFSSLVVRMEKRPLFYQKTYRVFTKDAAEGDHLSGDLR 341

Human   670 YTCIAGNSCNI--KH---------TEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAY 723
            :......||:.  ||         |.....:|:.|..:|            ||.:...:  .:..
Worm   342 FEVCTNGSCDAIEKHVSHLGLINGTIDDFIIVEYPYKQE------------IQIVVFLI--VICL 392

Human   724 IIAVLGLMFYCKKRCKA----------KRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALT 778
            :|.|..|.||.:.:.::          ||:....|             ||..:.|.|.:|.:...
Worm   393 LIVVSALAFYHRLKLQSFLREKILSFRKRISLAQE-------------LQTRRASQETEETLLRL 444

Human   779 SLGSGPAA--TNKRHSTSDKMHFP---RSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVK 838
            ...|..|:  ||        |..|   ..:::....|||..||||:||.    .:......|.||
Worm   445 EERSSLASDYTN--------MTLPFIDMGNIEIHEMLGKGHFGEVYLAS----WDYTGPRSVAVK 497

Human   839 SLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDE 903
            |::..|    :...:|..:...|.|.|:|:|.|:.|......:|.|:::.||||.:|    .:..
Worm   498 SIRRVD----MATEKEARVLQDLEHPNIVKLYGMTRNNFNLLLVFEHMNHGDLKTYL----EQRA 554

Human   904 KLKS------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQR------------ 950
            .:||      .||...:...:..::..|:.:|.....||:|||||||||:...
Worm   555 PVKSVYLQYPPPLVIDELKWIIKEITTGLVYLVEQSIVHRDLAARNCLVAGDSDLKATSHFERPP 619

Human   951 -QVKVSALGLSKDVY-NSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGE 1012
             :||:|..|:|:.:| :||||.. .:..:|:||:.|||:....|:..||:|:.||.|||..::|.
Worm   620 IRVKISDFGMSRRLYDHSEYYTMDHRGALPVRWLPPEAVQSHKFTYNSDIWSLGVTMWECMSYGR 684

Human  1013 MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1075
            .|..|.::.||.:...||...| :||.||..:|.||.:||.:.|..|.:..:|   |.|...|
Worm   685 QPFDGLSNLEVSSFTLAGMRPL-KPERCPQDMYDLMVKCWHMEPVKRITAKQI---LEDELFD 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653
		Ig	250..310	CDD:143165
		IG	348..416	CDD:214652
		IGc2	348..406	CDD:197706
		I-set	420..506	CDD:254352	6/43 (14%)
		Ig	422..506	CDD:299845	6/43 (14%)
		I-set	511..596	CDD:254352	19/122 (16%)
		IGc2	528..582	CDD:197706	12/65 (18%)
		IG_like	606..689	CDD:214653	20/107 (19%)
		IGc2	613..677	CDD:197706	14/77 (18%)
		PTK_CCK4	798..1071	CDD:133178	93/296 (31%)
		STYKc	809..1069	CDD:214568	91/280 (33%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	91/282 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910