DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK7 and sid-3

DIOPT Version :9

Sequence 1:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens
Sequence 2:	NP_510783.2	Gene:	sid-3 / 181756	WormBaseID:	WBGene00002207	Length:	1237	Species:	Caenorhabditis elegans

Alignment Length:	311	Identity:	96/311 - (30%)
Similarity:	148/311 - (47%)	Gaps:	41/311 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   773 EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEV---FLAKAQGLEEGVAETL 834
            ::|.:.:..|.||    ::|..:|...|...::....:|:..|..|   ...::.|....||
Worm    80 KQVYIQADQSMPA----QNSIDEKALIPNEQIKLYELIGEGSFAVVKRGTWTQSNGTHVNVA--- 137

Human   835 VLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG--------DL 891
              ||.|:........|.|.|.....||.|.:::||.|:.|  :|..||.|..:.|        |.
Worm   138 --VKILRDISPNIMDDLRVEASHLLKLQHPSLIRLYGIVR--QPAMMVFELCEGGSLLDRLRDDK 198

Human   892 KQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA-QRQVKVS 955
            |..|.:|:..|               .|.|:|..::.|.:...||:|:||||.|::. :|.||:.
Worm   199 KAILLVSRLHD---------------YCMQIAKALQFLESKHCVHRDVAARNILLARDERTVKIC 248

Human   956 ALGLSKDVYNSE--YYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQ 1018
            ..||.:.:..:|  |....|..||..|..|||:....||..||||::||.:|||||.||.|..|.
Worm   249 DFGLMRALKENEQMYTMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGC 313

Human  1019 ADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1069
            ...:||.::.||: ||.:|:.|..::|::|:.||..:|.:|..|..|...|
Worm   314 RAIDVLKNIDAGE-RLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDL 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653
		IGc2	53..113	CDD:197706
		Ig2_PTK7	154..230	CDD:143237
		IG_like	239..>309	CDD:214653
		Ig	250..310	CDD:143165
		IG	348..416	CDD:214652
		IGc2	348..406	CDD:197706
		I-set	420..506	CDD:254352
		Ig	422..506	CDD:299845
		I-set	511..596	CDD:254352
		IGc2	528..582	CDD:197706
		IG_like	606..689	CDD:214653
		IGc2	613..677	CDD:197706
		PTK_CCK4	798..1071	CDD:133178	90/286 (31%)
		STYKc	809..1069	CDD:214568	88/273 (32%)
sid-3	NP_510783.2	SAM_TNK-like	9..70	CDD:188938
		STYKc	107..363	CDD:214568	88/278 (32%)
		PTKc_Ack_like	111..365	CDD:270636	89/276 (32%)
		SH3	371..421	CDD:214620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910