DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTK7 and hir-1

DIOPT Version :9

Sequence 1:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens
Sequence 2:NP_504458.1 Gene:hir-1 / 178936 WormBaseID:WBGene00016059 Length:903 Species:Caenorhabditis elegans


Alignment Length:876 Identity:213/876 - (24%)
Similarity:333/876 - (38%) Gaps:247/876 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   350 TC----LPPKGLPEPS---------VWWEHAGVRLPTHGRV-YQKGHELVLANIAESDAGVYTCH 400
            ||    :|.|.||.|:         :.|.      |..|.| |..|:..:.:....||..|.|  
 Worm    73 TCNGELVPEKTLPAPTNLTLKGVRGLSWS------PVPGAVMYYIGYRTLNSKTFTSDDFVIT-- 129

Human   401 AANLAGQRRQDVNITVAT---VPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTV--------VWY 454
                   .:|.|:::..|   ..|.|:....:..|:|.......|..::||||.        :.|
 Worm   130 -------EKQTVDLSTLTNIDPCSELEVAVAAFSEDGIGNESKELKISSPKPTANPKLDLLELQY 187

Human   455 RNQMLISEDSRFEVFKNGTLRINSVEVYDGTWY---------------RCM-------------- 490
            .|..|:|:..:    .|.|:.:......| .|:               .|:              
 Worm   188 LNTTLVSDFYQ----ANATVHVEFRYKTD-PWFLGPDDLDVQPLFHLISCVDPDLSQGIPVPDFD 247

Human   491 ----SSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWE-----R 546
                :||.:.||.:....:....:.:......::|....:..:.|.||.    .||:.|     .
 Worm   248 VHVKNSTISTSIGSDMMDRKCRYVYYLQSVMSKKCNTMTEMPSPPSSAL----QTIQVECDIVKN 308

Human   547 ADGSSLPEWVTDNAGTLH---FARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV-FITFKVEPE 607
            |....:|.:.....|.:.   |:.::| |..|....|||           |||.| ||......|
 Worm   309 APCVKVPSYQPPLCGMVENVAFSVLSR-DRENLNDPASN-----------LTVNVTFIPVTRNNE 361

Human   608 RTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRM-HIF------------------- 652
            ..|:|  :..:....::...|.           :.|.||..: |:.                   
 Worm   362 MPTLY--YIGIFGTASEYHTKE-----------EETFLGVNITHVIGKESSCTGFDSSGNCLAEN 413

Human   653 QNGSLVIHDVAPE-----------------------DSGRYTCIAGNSCNIKHTEAPLYVVDKPV 694
            .|.|:|:..:.|:                       ||..:...|.....:.||           
 Worm   414 LNRSIVLQGIHPKTLYGLTICAVKDIRNLTLPDVTLDSKSFRAKADRIMLVAHT----------- 467

Human   695 PEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNG 759
                    |..|..||  ||:.:|:.|..::|::.:.||.:|:.:..:.:.|.|           
 Worm   468 --------SNNPVGMI--IGIVIGSLVVILVAIVVIWFYFRKKSENMKFKFQME----------- 511

Human   760 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSL--QPITTLGKSEFGEVFLAK 822
               |.|:.:.....:..:.      ||.|      |.....|.:|  .....||...||.|:|.|
 Worm   512 ---QVGKNNMNRYIDFPIM------AAKN------DIWEIERRNLIIHNDKKLGSGAFGAVYLGK 561

Human   823 AQGLE---------EGV----AETL-VLVKSL-QSKDEQQQLDFRRELEMFGKLN-HANVVRLLG 871
            ..|..         .|:    ||.. |.||.| :..||..:.:|.||:.:...|. |..:|.:|.
 Worm   562 LIGKSLAHKDANSPLGINLMRAENCQVAVKMLPEYADEMSKHEFLREIALMKTLGYHERLVNMLA 626

Human   872 LCREAEPHYMVLEYVDLGDLKQFLR-----ISKSKD-----------EKLKSQPLST-KQKVALC 919
            ...|:||..:|:||.|.|||.:|||     :.|..|           |...:..:.| ||.:...
 Worm   627 CVTESEPLCLVVEYCDNGDLLKFLRERCKYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFA 691

Human   920 TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY-NSEYYHFRQAWVPLRWMSP 983
            .|::.|:|:||...|||:|:||||.||......|:...||.:.:| :...|..:...:||:||||
 Worm   692 VQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSP 756

Human   984 EAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLM 1048
            |||...:||.|||:|:||:|::||.|.|..|:.|...::||..|:.| .|:.:|:.||...|.:|
 Worm   757 EAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPGMPPEDVLPFLEGG-GRIEKPDNCPENFYDVM 820

Human  1049 QRCWALSPKDRPSFSEI----ASALGDSTVD 1075
            .:||...|.||..||::    |:.|.|.|.|
 Worm   821 MQCWNADPDDRIEFSDVRMQLATQLEDITED 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTK7NP_001257327.1 IG_like 46..120 CDD:214653
IGc2 53..113 CDD:197706
Ig2_PTK7 154..230 CDD:143237
IG_like 239..>309 CDD:214653
Ig 250..310 CDD:143165
IG 348..416 CDD:214652 19/79 (24%)
IGc2 348..406 CDD:197706 17/69 (25%)
I-set 420..506 CDD:254352 22/126 (17%)
Ig 422..506 CDD:299845 21/124 (17%)
I-set 511..596 CDD:254352 18/92 (20%)
IGc2 528..582 CDD:197706 14/61 (23%)
IG_like 606..689 CDD:214653 17/125 (14%)
IGc2 613..677 CDD:197706 12/106 (11%)
PTK_CCK4 798..1071 CDD:133178 108/312 (35%)
STYKc 809..1069 CDD:214568 105/297 (35%)
hir-1NP_504458.1 fn3 85..163 CDD:365830 19/92 (21%)
PTKc 547..842 CDD:270623 104/295 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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