DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MIB1 and ASP3-3

DIOPT Version :9

Sequence 1:	NP_065825.1	Gene:	MIB1 / 57534	HGNCID:	21086	Length:	1006	Species:	Homo sapiens
Sequence 2:	NP_013259.1	Gene:	ASP3-3 / 850855	SGDID:	S000004148	Length:	362	Species:	Saccharomyces cerevisiae

Alignment Length:	308	Identity:	58/308 - (18%)
Similarity:	110/308 - (35%)	Gaps:	77/308 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   371 RVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEEL 435
            ::::..:.|...:::.||..|        :||.||..:..:|..:...:..|.|...|  |.|:
Yeast    23 KIREEKNSSLPSIKIFGTGGT--------IASKGSTSATTAGYSVGLTVNDLIEAVPS--LAEK- 76

Human   436 VKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRA 500
                ||.|..:|.::                   .::...:..::.|....:..:.::|..|...
Yeast    77 ----ANLDYLQVSNV-------------------GSNSLNYTHLIPLYHGISEALASDDYAGAVV 118

Human   501 VHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS-EGD 564
            .|.....:|.|..       .||...:::   |:.||   |.::           |:...| :|.
Yeast   119 THGTDTMEETAFF-------LDLTINSEK---PVCIA---GAMR-----------PATATSADGP 159

Human   565 TPLHDAISKKRDDILAVLLEAGADVTITNN----NGF-----NALHHAALRGNPSAMRVLLSKLP 620
            ..|:.|:|     |.|.....|....||.|    :||     ||......|.:........|...
Yeast   160 MNLYQAVS-----IAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDD 219

Human   621 RPWIVDEKKDDGYTALHLAALNNHVEVAELLV---HQG-NANLDIQNV 664
            ..:.....|.:|:....::.|.:..|:.|:::   :|| |..|.::.|
Yeast   220 VEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAV 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MIB1	NP_065825.1	MIB_HERC2	15..72	CDD:399589
		ZZ_Mind_bomb	83..127	CDD:239079
		MIB_HERC2	154..218	CDD:399589
		SH3_15	246..311	CDD:408152
		SH3_15	333..397	CDD:408152	4/25 (16%)
		ANK 1	430..460		6/29 (21%)
		PHA03095	439..>710	CDD:222980	44/240 (18%)
		ANK 2	463..492		1/28 (4%)
		ANK repeat	464..494	CDD:293786	1/29 (3%)
		ANK repeat	496..560	CDD:293786	11/63 (17%)
		ANK 3	496..525		6/28 (21%)
		ANK 4	529..558		5/28 (18%)
		ANK repeat	562..593	CDD:293786	8/30 (27%)
		ANK 5	562..591		7/28 (25%)
		ANK 6	595..627		6/36 (17%)
		ANK repeat	631..663	CDD:293786	8/35 (23%)
		ANK 7	631..661		8/33 (24%)
		ANK repeat	665..696	CDD:293786	58/308 (19%)
		ANK 8	665..694		58/308 (19%)
		Ank_2	670..770	CDD:403870
		ANK 9	698..729
		RING1-HC_MIB1	818..854	CDD:319638
		RING2-HC_MIB1	865..901	CDD:319639
		RING3-HC_MIB1	962..1003	CDD:319641
ASP3-3	NP_013259.1	asnASE_II	9..359	CDD:273115	58/308 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910