DRSC/TRiP Functional Genomics Resources

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Protein Alignment MIB1 and mib1

DIOPT Version :9

Sequence 1:NP_065825.1 Gene:MIB1 / 57534 HGNCID:21086 Length:1006 Species:Homo sapiens
Sequence 2:NP_648826.2 Gene:mib1 / 39750 FlyBaseID:FBgn0263601 Length:1226 Species:Drosophila melanogaster


Alignment Length:1147 Identity:710/1147 - (61%)
Similarity:829/1147 - (72%) Gaps:170/1147 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     8 RVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILD 72
            |..:|||||||:|||||||.|||||||||||||:|||.|||||||||||||||||:|||||||||
  Fly   102 RFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILD 166

Human    73 SAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLL 137
            |||||:||:||||||||||||.|||||||||.|||||::||||||||||||||||||||.||.:|
  Fly   167 SAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTML 231

Human   138 ESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAK 202
            |.||||||:.|||||.||||||||||||||||||.||||||.||||||::||.|||||:||||:|
  Fly   232 EPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSK 296

Human   203 NLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHG 267
            ||||||||||:|||.|.||||.:.||||.|:|||....:.|.|.||||.|.:|||||||||||||
  Fly   297 NLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHG 361

Human   268 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQ 332
            ||||||||||.|:..|.|.||||||||||.|.||||||||||||||   |.|...|      ..:
  Fly   362 HGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTK---VSSPTTA------PPE 417

Human   333 FQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV 397
            |||||:|::|.|:|.||:|||||||||:||..||||:|||||:|.|:||||||..|||||||.||
  Fly   418 FQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAV 482

Human   398 SKVASAGSAISNA-----SGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLL------ 451
            .||||:.::..:.     |.||||.:||||||...|||..||.|||||||..|:.|:.|      
  Fly   483 CKVASSTASDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAAQP 547

Human   452 --------KRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD 508
                    ..|||:|||..|||||:||||||||::::::||:..||||.||||||||||||||||
  Fly   548 STSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGD 612

Human   509 EGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
            |.||||:|.:..||||||||||||.||||||||||.||||||..|||||||||||||||||||||
  Fly   613 EAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISK 677

Human   574 KRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHL 638
            :.|::|::||:.|||:|:.|||||||||||||:||||||::||:|..|||||:||||||||||||
  Fly   678 EHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHL 742

Human   639 AALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL 703
            ||||||||:||||||.|.||:|.||||.||||||||||||.|||:|||:.||.|:|.||||||||
  Fly   743 AALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPL 807

Human   704 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSI 768
            ||||||||||||:||||::..||           |:||| .....||::||||||||||||||::
  Fly   808 HEALRHHTLSQLKQLQDVEGFGK-----------LLMGL-RNANNKKASASIACFLAANGADLTL 860

Human   769 RNKKGQSPLDLCPDPNLCKALAKCHKEK------VSGQVGSRSPSM------------------- 808
            :|:|.|:||||||||||||.|.||:.|:      :.|.|...|.|.                   
  Fly   861 KNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNMPL 925

Human   809 ----------------------ISND------------SETLEECMVCSDMKRDTLFGPCGHIAT 839
                                  |:|:            |.:|:||:||||.||||:|.||||::.
  Fly   926 SSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKPCGHVSC 990

Human   840 CSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVV 904
            |..|:|||||||||:|.|.||.||:||:||||::|||.|:|||||.|||:|:.||||||.||..:
  Fly   991 CETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRTQI 1055

Human   905 ERRVPFIMCCGGKSSED------------------------------------------------ 921
            :..:.|.:||||....:                                                
  Fly  1056 DEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVTPV 1120

Human   922 ------------------ATDDIS----SGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCP 964
                              |:.::|    :||..|...:.:|..:: |||||:|||||||||||||
  Fly  1121 AGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMD-DVQKLKQQLQDIKEQTMCP 1184

Human   965 VCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY 1006
            ||.||:|||:|||||||||:|||::..||||||.:|:||||:
  Fly  1185 VCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF 1226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MIB1NP_065825.1 MIB_HERC2 15..72 CDD:399589 51/56 (91%)
ZZ_Mind_bomb 83..127 CDD:239079 39/43 (91%)
MIB_HERC2 154..218 CDD:399589 55/63 (87%)
SH3_15 246..311 CDD:408152 52/64 (81%)
SH3_15 333..397 CDD:408152 46/63 (73%)
ANK 1 430..460 17/43 (40%)
PHA03095 439..>710 CDD:222980 207/284 (73%)
ANK 2 463..492 18/28 (64%)
ANK repeat 464..494 CDD:293786 18/29 (62%)
ANK repeat 496..560 CDD:293786 53/63 (84%)
ANK 3 496..525 22/28 (79%)
ANK 4 529..558 24/28 (86%)
ANK repeat 562..593 CDD:293786 20/30 (67%)
ANK 5 562..591 19/28 (68%)
ANK 6 595..627 25/31 (81%)
ANK repeat 631..663 CDD:293786 26/31 (84%)
ANK 7 631..661 25/29 (86%)
ANK repeat 665..696 CDD:293786 23/30 (77%)
ANK 8 665..694 22/28 (79%)
Ank_2 670..770 CDD:403870 65/99 (66%)
ANK 9 698..729 24/30 (80%)
RING1-HC_MIB1 818..854 CDD:319638 25/35 (71%)
RING2-HC_MIB1 865..901 CDD:319639 25/35 (71%)
RING3-HC_MIB1 962..1003 CDD:319641 29/40 (73%)
mib1NP_648826.2 MIB_HERC2 109..165 CDD:284184 50/55 (91%)
ZZ_Mind_bomb 177..221 CDD:239079 39/43 (91%)
MIB_HERC2 248..312 CDD:284184 55/63 (87%)
Ank_4 568..620 CDD:290365 39/51 (76%)
ANK repeat 568..598 CDD:293786 18/29 (62%)
ANK repeat 600..631 CDD:293786 24/30 (80%)
Ank_2 606..697 CDD:289560 70/90 (78%)
ANK 628..756 CDD:238125 104/127 (82%)
ANK repeat 633..664 CDD:293786 26/30 (87%)
ANK repeat 666..695 CDD:293786 19/28 (68%)
ANK repeat 699..733 CDD:293786 26/33 (79%)
Ank_2 704..800 CDD:289560 76/95 (80%)
ANK 734..872 CDD:238125 105/149 (70%)
ANK repeat 735..767 CDD:293786 26/31 (84%)
ANK repeat 769..800 CDD:293786 23/30 (77%)
Ank_2 774..862 CDD:289560 65/99 (66%)
ANK repeat 802..862 CDD:293786 44/71 (62%)
zf-C3HC4_3 968..1011 CDD:290631 28/42 (67%)
zf-C3HC4_3 1013..1058 CDD:290631 29/44 (66%)
zf-C3HC4_3 1179..1222 CDD:290631 32/42 (76%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142962
Domainoid 1 1.000 126 1.000 Domainoid score I5449
eggNOG 1 0.900 - - E1_KOG4582
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10810
Inparanoid 1 1.050 1324 1.000 Inparanoid score I149
Isobase 1 0.950 - 0 Normalized mean entropy S3154
OMA 1 1.010 - - QHG46014
OrthoDB 1 1.010 - - D119594at33208
OrthoFinder 1 1.000 - - FOG0002693
OrthoInspector 1 1.000 - - oto89508
orthoMCL 1 0.900 - - OOG6_104088
Panther 1 1.100 - - LDO PTHR24202
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4659
SonicParanoid 1 1.000 - - X100
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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