DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HACE1 and hace1

DIOPT Version :9

Sequence 1:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens
Sequence 2:	XP_701235.5	Gene:	hace1 / 572430	ZFINID:	ZDB-GENE-110411-52	Length:	905	Species:	Danio rerio

Alignment Length:	923	Identity:	788/923 - (85%)
Similarity:	840/923 - (91%)	Gaps:	33/923 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MERAME----QLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAF 61
            ||||||    ||||||||||||||||||||:|||||||||||||||||||||||.||||||||||
Zfish     2 MERAMEHLNVQLNRLTRSLRRARTVELPEDSETAVYTLMPMVMADQHRSVSELLLNSKFDVNYAF 66

Human    62 GRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||.:||||:|||||
Zfish    67 GRVKRSLLHIAANCGSVECLVLLLKRGANPNYQDISGCTPLHLAARNGQKKCMGRLLEYNADVNI 131

Human   127 CNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADIN 191
            ||||||||||||||||||||||||||||::|||||||||||||||||||||||||||||||||||
Zfish   132 CNNEGLTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADIN 196

Human   192 RPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLF 256
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||:|||:|.|||
Zfish   197 RPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDRNGVTPLDLCVQGGYGETCEILIQHHGRLF 261

Human   257 QTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLL 321
            ||:||||||:|::||||||||||:|||::|.|.:||||||||||||||||||||||::.|.||||
Zfish   262 QTLIQMTQNDDIKENMLRQVLEHVSQQNDSNYQRILTSLAEVATTNGHKLLSLSSNFEVQTKSLL 326

Human   322 RIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKRDST 386
            ||:|:|||||.:|||||:||.||||||||||||||||||||||||||||||||:|||.|...|:|
Zfish   327 RIIRIFCHVFCLGPSSPNNGNDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLISTELEKEITDTT 391

Human   387 ------EITSILLKQKGQDQDAASIPPFEPPGPGSYEN----LSTGTRESKPDALAGRQEASADC 441
                  :|.|:.||::..|...:|            ||    |...:....|       |..||.
Zfish   392 RSSSGNDIASLFLKKQEVDHSVSS------------ENPQLLLDASSVMKTP-------EVYADG 437

Human   442 QDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLL 506
            ||||||.||||||||||||||||||||.||||||||||||||||||||||.|||||||:||||||
Zfish   438 QDVISMIANRLSAVIQAFYMCCSCQMPHGMTSPRFIEFVCKHDEVLKCFVTRNPKIIFNHFHFLL 502

Human   507 ECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVS 571
            ||||||||||||||.||||||||||||||.:||||||||||||||||||||||||:|||||||||
Zfish   503 ECPELMSRFMHIIKGQPFKDRCEWFYEHLLAGQPDSDMVHRPVNENDILLVHRDSLFRSSCEVVS 567

Human   572 KANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPD 636
            |::..||||||||||||||||||||||||||||||||:||||||||||||||||||||||.||||
Zfish   568 KSSNEKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIINPDYALFTQSADGTTFQPNSNSSVNPD 632

Human   637 HLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISD 701
            ||||||||||||||||.||||||||||||||||||||||:||||:||||||||||||||||||||
Zfish   633 HLNYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWILDNDISD 697

Human   702 LGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHM 766
            |||||||||||||||.||||||||||.:|.|||:||.|||||||||||||||||||||||||||.
Zfish   698 LGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHT 762

Human   767 FIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLL 831
            |||||||||||||||||||||||||||.||.:||||||||:.::|||||||||||::||||||||
Zfish   763 FIPPSLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVLL 827

Human   832 LQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLL 896
            ||||||||||||||||.:|||||||.||:||||||.|||||||||||||||||||||::|:||||
Zfish   828 LQFVTGSSRVPHGGFAFLMGGSGLQKFTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLL 892

Human   897 VALHCGSYGYTMA 909
            |||||||||||||
Zfish   893 VALHCGSYGYTMA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	238/255 (93%)
		ANK 1	64..93		27/28 (96%)
		ANK repeat	66..95	CDD:293786	27/28 (96%)
		ANK	92..217	CDD:238125	119/124 (96%)
		ANK repeat	97..128	CDD:293786	27/30 (90%)
		ANK 2	97..126		25/28 (89%)
		ANK repeat	130..161	CDD:293786	28/30 (93%)
		ANK 3	130..159		26/28 (93%)
		ANK repeat	163..194	CDD:293786	30/30 (100%)
		ANK 4	163..192		28/28 (100%)
		ANK 5	196..226		29/29 (100%)
		ANK repeat	196..221	CDD:293786	24/24 (100%)
		ANK 6	228..257		25/28 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		6/38 (16%)
		HECTc	554..903	CDD:238033	314/348 (90%)
hace1	XP_701235.5	ANK repeat	71..100	CDD:293786	27/28 (96%)
		ANK	71..98	CDD:197603	25/26 (96%)
		Ank_2	74..199	CDD:289560	118/124 (95%)
		ANK	97..222	CDD:238125	119/124 (96%)
		ANK repeat	102..133	CDD:293786	27/30 (90%)
		ANK repeat	135..166	CDD:293786	28/30 (93%)
		Ank_2	140..227	CDD:289560	84/86 (98%)
		ANK repeat	168..199	CDD:293786	30/30 (100%)
		ANK repeat	201..226	CDD:293786	24/24 (100%)
		Ank_4	204..254	CDD:290365	47/49 (96%)
		ANK repeat	233..261	CDD:293786	24/27 (89%)
		HECTc	550..899	CDD:238033	314/348 (90%)
		HECTc	575..898	CDD:214523	293/322 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194323920
Domainoid	1	1.000	556	1.000	Domainoid score	I2089
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10807
Inparanoid	1	1.050	1584	1.000	Inparanoid score	I808
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43689
OrthoDB	1	1.010	-	-		D140374at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		oto51296
orthoMCL	1	0.900	-	-		OOG6_112018
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6931
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410