Protein Alignment HACE1 and hace1

DIOPT Version :10

• Sequence 1: NP_065822.2
• Gene: HACE1 / 57531
• HGNCID: 21033
• Length: 909
• Species: Homo sapiens
• Sequence 2: NP_001410905.1
• Gene: hace1 / 572430
• ZFINID: ZDB-GENE-110411-52
• Length: 905
• Species: Danio rerio
• Alignment Length: 923
• Identity: 788/923 - (85%)
• Similarity: 840/923 - (91%)
• Gaps: 33/923 - (3%)

Human     1 MERAME----QLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAF 61
            ||||||    ||||||||||||||||||||:|||||||||||||||||||||||.||||||||||
Zfish     2 MERAMEHLNVQLNRLTRSLRRARTVELPEDSETAVYTLMPMVMADQHRSVSELLLNSKFDVNYAF 66

Human    62 GRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||.:||||:|||||
Zfish    67 GRVKRSLLHIAANCGSVECLVLLLKRGANPNYQDISGCTPLHLAARNGQKKCMGRLLEYNADVNI 131

Human   127 CNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADIN 191
            ||||||||||||||||||||||||||||::|||||||||||||||||||||||||||||||||||
Zfish   132 CNNEGLTAIHWLAVNGRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADIN 196

Human   192 RPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLF 256
            |||||||||||||||||||||||||||||||||||:|||||||||||||||||||:|||:|.|||
Zfish   197 RPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDRNGVTPLDLCVQGGYGETCEILIQHHGRLF 261

Human   257 QTIIQMTQNEDLRENMLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLL 321
            ||:||||||:|::||||||||||:|||::|.|.:||||||||||||||||||||||::.|.||||
Zfish   262 QTLIQMTQNDDIKENMLRQVLEHVSQQNDSNYQRILTSLAEVATTNGHKLLSLSSNFEVQTKSLL 326

Human   322 RIVRMFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKRDST 386
            ||:|:|||||.:|||||:||.||||||||||||||||||||||||||||||||:|||.|...|:|
Zfish   327 RIIRIFCHVFCLGPSSPNNGNDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLISTELEKEITDTT 391

Human   387 ------EITSILLKQKGQDQDAASIPPFEPPGPGSYEN----LSTGTRESKPDALAGRQEASADC 441
                  :|.|:.||::..|...:|            ||    |...:....|       |..||.
Zfish   392 RSSSGNDIASLFLKKQEVDHSVSS------------ENPQLLLDASSVMKTP-------EVYADG 437

Human   442 QDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLL 506
            ||||||.||||||||||||||||||||.||||||||||||||||||||||.|||||||:||||||
Zfish   438 QDVISMIANRLSAVIQAFYMCCSCQMPHGMTSPRFIEFVCKHDEVLKCFVTRNPKIIFNHFHFLL 502

Human   507 ECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVS 571
            ||||||||||||||.||||||||||||||.:||||||||||||||||||||||||:|||||||||
Zfish   503 ECPELMSRFMHIIKGQPFKDRCEWFYEHLLAGQPDSDMVHRPVNENDILLVHRDSLFRSSCEVVS 567

Human   572 KANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPD 636
            |::..||||||||||||||||||||||||||||||||:||||||||||||||||||||||.||||
Zfish   568 KSSNEKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIINPDYALFTQSADGTTFQPNSNSSVNPD 632

Human   637 HLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISD 701
            ||||||||||||||||.||||||||||||||||||||||:||||:||||||||||||||||||||
Zfish   633 HLNYFRFAGQILGLALYHRQLVNIYFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWILDNDISD 697

Human   702 LGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHM 766
            |||||||||||||||.||||||||||.:|.|||:||.|||||||||||||||||||||||||||.
Zfish   698 LGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHT 762

Human   767 FIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLL 831
            |||||||||||||||||||||||||||.||.:||||||||:.::|||||||||||::||||||||
Zfish   763 FIPPSLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVLL 827

Human   832 LQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLL 896
            ||||||||||||||||.:|||||||.||:||||||.|||||||||||||||||||||::|:||||
Zfish   828 LQFVTGSSRVPHGGFAFLMGGSGLQKFTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLL 892

Human   897 VALHCGSYGYTMA 909
            |||||||||||||
Zfish   893 VALHCGSYGYTMA 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HACE1	NP_065822.2	N-terminal helix important for homodimerization. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367	1..21		19/23 (83%)
		ANK 1. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	23..55		29/31 (94%)
		ANKYR	26..249	CDD:440430	212/222 (95%)
		ANK 2. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	64..93		27/28 (96%)
		ANK repeat	66..95	CDD:293786	27/28 (96%)
		ANK repeat	97..128	CDD:293786	27/30 (90%)
		ANK 3. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	97..126		25/28 (89%)
		ANK repeat	130..161	CDD:293786	28/30 (93%)
		ANK 4. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	130..159		26/28 (93%)
		ANK repeat	163..194	CDD:293786	30/30 (100%)
		ANK 5. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	163..192		28/28 (100%)
		ANK 6. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	196..226		29/29 (100%)
		ANK repeat	196..221	CDD:293786	24/24 (100%)
		ANK 7. /evidence=ECO:0000269|PubMed:37537642, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8H8X, ECO:0007744|PDB:8HAE, ECO:0007744|PDB:8PWL	228..253		22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..433		6/38 (16%)
		HECTc	554..903	CDD:238033	314/348 (90%)
hace1	NP_001410905.1	ANKYR	37..254	CDD:440430	207/216 (96%)
		ANK repeat	71..100	CDD:293786	27/28 (96%)
		ANK repeat	102..133	CDD:293786	27/30 (90%)
		ANK repeat	135..166	CDD:293786	28/30 (93%)
		ANK repeat	168..199	CDD:293786	30/30 (100%)
		ANK repeat	201..226	CDD:293786	24/24 (100%)
		ANK repeat	233..261	CDD:293786	24/27 (89%)
		HECTc	550..899	CDD:238033	314/348 (90%)