DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HACE1 and ptr1

DIOPT Version :9

Sequence 1:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens
Sequence 2:NP_594902.1 Gene:ptr1 / 2542537 PomBaseID:SPAC19D5.04 Length:3227 Species:Schizosaccharomyces pombe


Alignment Length:1024 Identity:274/1024 - (26%)
Similarity:451/1024 - (44%) Gaps:255/1024 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     2 ERAMEQLNR-LTRSLRRARTV----ELPEDN---ETAVYTLMPMVMADQHRSVSELLSNSKFD-- 56
            |..||:::: .|.|..|.::|    ::|..|   ...:|:|:.::...||..     .|..:|  
pombe  2343 EVEMEEIDQGGTVSEHREKSVKPVKKIPVPNLLDRQGLYSLIRLIFISQHNG-----KNPYYDLI 2402

Human    57 VNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPN-------YQDISGCTPLHLAARNGQKKCM 114
            ||.:..:..|:         .:..|:|.:.:.|:.|       |:|::     ..:..|.|:|.:
pombe  2403 VNISENKQHRA---------DIVGLLLYILQEASINDRASEKCYRDLT-----VKSLNNSQQKEV 2453

Human   115 SK---LLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSD---------VDVEDAMGQTA 167
            .|   |||....|.:.|  |::|...:...|     .||:.|::.         :.:.|..|..:
pombe  2454 KKSTGLLESLCKVPVVN--GISAPALILQQG-----IDLLSHLATWADHFASFFLSMHDFSGIAS 2511

Human   168 LHVACQNGHKTTVQCLLDSGADIN-------RPNVSGAT---------------PL--YFACSHG 208
            ...|.:...::.|..:    |.||       |..:.|.|               ||  ::.....
pombe  2512 KKSAGRKNRESNVYKI----APINVLLGLLAREELFGNTLVMNTFSELLSTLTKPLLSFYKSEKL 2572

Human   209 QRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENML 273
            |:|:|..                        ||                     |.::|.|.:.:
pombe  2573 QKDSATT------------------------GY---------------------TNDQDSRGSTV 2592

Human   274 RQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMK---SLLRIVRMFCHVFRIGP 335
            .:                 ......|:....|:||..:..|..::   ||:.........|:   
pombe  2593 PK-----------------QDPGTTASRKDKKILSPPNILDENLRLAASLITTDSCSSRTFQ--- 2637

Human   336 SSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATEL------MKNKRDSTEITSILL- 393
                |.:.:.::.:..|::::....|||.|. .|:...|..:|      :|:.::.:|:...|. 
pombe  2638 ----NALSVMFHLSSIPKAKILIGKELLRHG-QEYGNSITNDLSRLCADVKSGKNESELQVALAP 2697

Human   394 ------------------------KQKGQDQDAASIPPFEPPGPGS-------YENLSTGTRESK 427
                                    :.|||:|           .||:       |:||.       
pombe  2698 FCPASSNQAKLLRCLKALDYIFERRPKGQEQ-----------SPGNIIQLLEFYDNLK------- 2744

Human   428 PDALAGRQEASADC----QDVISMT--ANRLSAVIQAFYMCCS---CQMPPGM---TSP------ 474
               .:...|..::|    :|..|:|  :..|..:|::..:.|.   .::|..:   .||      
pombe  2745 ---FSSLWEVLSECLSALRDHTSITHVSTVLLPLIESLMVICRLVFIELPEDVGKHISPILERFK 2806

Human   475 -RFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSG 538
             .||.|..:|.:::...|...|.::...|..|::.|:::.          |:::..:|...||  
pombe  2807 TLFISFTEEHRKIINMMVFTTPSLMSGSFSLLVKNPKVLE----------FENKRNYFNRQLH-- 2859

Human   539 QPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLK-QGIAVRFHGEEGM-GQGVVREWF 601
            :..:...:.|:|    :.|.||.:|..|...:...:..::| ..:.:.|..|||: ..||.|||.
pombe  2860 EEAAKEQYPPLN----ITVRRDHVFLDSYRALHFKDADEVKFSKLNIHFRDEEGVDAGGVTREWL 2920

Human   602 DILSNEIVNPDYALFTQ-SADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRS 665
            .:|:.::.|||||||.. :.|.|||.||.:|.||||||::|:|.|:|:|.||...:|::.:|:|:
pombe  2921 QVLARQMFNPDYALFLPVTGDATTFHPNRDSSVNPDHLSFFKFTGRIIGKALYDGRLLDCHFSRA 2985

Human   666 FYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSI 730
            .|||:|...|:.:|:.|:||:|.|:|.|:|:|||:|:..| .|:||.||||....|.|.|.|.:|
pombe  2986 VYKHMLHRSVSVKDIESLDPDYYKSLVWMLNNDITDIITE-EFAVEKDVFGEKTVVDLIPNGRNI 3049

Human   731 LVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSD 795
            .||:.||..||..:.:.::..:::.|:.:.|.||...||..|||:|:|.|||||:||:||||:.|
pombe  3050 PVTELNKQNYVNRMVDYKLRESVKDQLKSLLDGFSDIIPSHLIQIFNEQELELLISGLPEIDIDD 3114

Human   796 WIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTI 860
            |..|||| .||....|.:||||..|....:|||..||||.||:|:||..||..:.|.||.|.|.|
pombe  3115 WKNNTEY-HGYNVSSPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPLNGFKELEGMSGFQRFNI 3178

Human   861 AAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 909
            .....:.|.||.|.||.|.|.||||.:.|.|:..||.|::.||.|:..|
pombe  3179 HKSYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSMLLTAINEGSEGFGFA 3227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894 51/303 (17%)
ANK 1 64..93 5/35 (14%)
ANK repeat 66..95 CDD:293786 6/35 (17%)
ANK 92..217 CDD:238125 33/167 (20%)
ANK repeat 97..128 CDD:293786 8/33 (24%)
ANK 2 97..126 8/31 (26%)
ANK repeat 130..161 CDD:293786 6/39 (15%)
ANK 3 130..159 6/37 (16%)
ANK repeat 163..194 CDD:293786 7/37 (19%)
ANK 4 163..192 6/35 (17%)
ANK 5 196..226 7/46 (15%)
ANK repeat 196..221 CDD:293786 7/41 (17%)
ANK 6 228..257 2/28 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433 7/41 (17%)
HECTc 554..903 CDD:238033 156/351 (44%)
ptr1NP_594902.1 DUF908 96..367 CDD:283630
DUF913 436..735 CDD:283642
HARE-HTH <1930..2018 CDD:294801
DUF4414 2267..2347 CDD:291075 1/3 (33%)
HUL4 2314..3227 CDD:227354 273/1022 (27%)
HECTc 2870..3225 CDD:238033 160/360 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.870

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