DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK6 and LSB1

DIOPT Version :9

Sequence 1:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens
Sequence 2:	NP_011652.1	Gene:	LSB1 / 853037	SGDID:	S000003368	Length:	241	Species:	Saccharomyces cerevisiae

Alignment Length:	185	Identity:	39/185 - (21%)
Similarity:	73/185 - (39%)	Gaps:	55/185 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    12 KYV-GLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVES 75
            :|| .|:||:::.|.:||.:.||...|..|....|:.   .::...:  |..|.||:
Yeast    56 EYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYR---GKSNNKI--GIFPANYV-------- 107

Human    76 EPWFFGCISRSEAVRRLQAEGNATGAFLIRVS-EKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139
            :|.|    :||.:.:..:|..::|   :.|.| ..||.:...|...:|.|
Yeast   108 KPAF----TRSASPKSAEAASSST---VSRPSVPPPSYEPAASQYPSQQV--------------- 150

Human   140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHE---PEPLPHWDDWERPREEF 191
                   |.|        .:...|...|.|.::.:   |.|.|..:.:::|::::
Yeast   151 -------SAP--------YAPPAGYMQAPPPQQQQAPLPYPPPFTNYYQQPQQQY 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	17/57 (30%)
		SH2_PTK6_Brk	75..174	CDD:198221	18/99 (18%)
		Linker	171..190		4/21 (19%)
		PTKc_Srm_Brk	184..444	CDD:133248	1/8 (13%)
		STYKc	192..441	CDD:214568	39/185 (21%)
LSB1	NP_011652.1	SH3	55..108	CDD:214620	17/64 (27%)
LSB1	NP_011652.1	PRK14971	<100..>156	CDD:237874	19/100 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000