DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTK6 and Src64B

DIOPT Version :9

Sequence 1:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	197/452 - (43%)
Similarity:	262/452 - (57%)	Gaps:	31/452 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWW----ATLLDEAGGAVAQGYVPHNYLAERETVE 74
            |.|:|:|||.:.:|||..||...|....|..||    .|...|       |.:|.|::||..:|.
  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQE-------GLIPLNFVAEERSVN 158

Human    75 SEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQ-----AVRHYKIWRRAG 134
            ||.|||..:.|.||.:.|.||.|..|.||:|.||.....|.|||:|.:     .|:||:|.....
  Fly   159 SEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDN 223

Human   135 GRLHLNEAVSFLSLPELV-NYHRAQSLSHGLRLAAPCRKHEPEPLPHW-------DDWERPREEF 191
            |..::....:|.||..|| .|.:..:|.....|:.||.|.:|:   .|       |.:|.||.|.
  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQ---MWDLGPELRDKYEIPRSEI 285

Human   192 TLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256
            .|.||||.|.|||||.|.|::.:.||:|.:....:.....|| |...|||.||..::|||||.|.
  Fly   286 QLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQ-EAAIMKKFRHNRLVALYAVCSQ 349

Human   257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG 321
            .:|:||:.|.|:|||||:.||:.|.:.|...:|:.||.|||.||.||||:..|||||||||:|:|
  Fly   350 EEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIG 414

Human   322 ENTLCKVGDFGLARLIKEDVYL-SHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQ 385
            ||.:.|:.||||||:|.:|.|. ......|.|||||||:..|.:|.||||||:||||.|:|:.||
  Fly   415 ENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQ 479

Human   386 VPYPGMSNHEAFLRVDAGYRMPCPLE--CPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFT 445
            ||||||.:.|....::.|:|||.|..  .|.::::|:|.||...||:||.|:.|.....||:
  Fly   480 VPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	20/58 (34%)
		SH2_PTK6_Brk	75..174	CDD:198221	39/104 (38%)
		Linker	171..190		7/25 (28%)
		PTKc_Srm_Brk	184..444	CDD:133248	130/262 (50%)
		STYKc	192..441	CDD:214568	126/251 (50%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/55 (35%)
		SH2_Src_family	158..259	CDD:199827	36/100 (36%)
		STYKc	285..537	CDD:214568	126/252 (50%)
		PTKc_Src_like	289..538	CDD:270630	125/249 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820