DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK6 and wnd

DIOPT Version :9

Sequence 1:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	86/270 - (31%)
Similarity:	132/270 - (48%)	Gaps:	31/270 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   182 DDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKH 246
            :||:.|.|..|....||||..|.||.|..|:.. ||:|.:       :::.:::|:.::||.|::
  Fly   152 EDWQIPFESITELEWLGSGAQGAVFSGRLKNET-VAVKKV-------KELKETDIKHLRKLDHEN 208

Human   247 ILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHR 311
            |:....|.:......||.|....|.|..:|:  :|:|:..|.|:..:.|:|.||.||.|...|||
  Fly   209 IIKFKGVCTQSPVFCIIMEFCPYGPLQNILK--EEQVMLPSRLVSWSKQIALGMQYLHSHKIIHR 271

Human   312 DLAARNILVGENTLCKVGDFGLARLIKE-DVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGI 375
            ||.:.|||:..|.:.|:.|||.:|...| ...:|....:  .|.|||.:.....|.|.|:||:|:
  Fly   272 DLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTV--AWMAPEVIRNEPCSEKVDIWSYGV 334

Human   376 LLHEMFSRGQVPYP---------GMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQR 431
            :|.||.: .::||.         |:.|:...|.|        |..||.....|:..||...|..|
  Fly   335 VLWEMLT-CEIPYKDVDSSAIIWGVGNNSLKLLV--------PSTCPEGFKLLVKLCWKSKPRNR 390

Human   432 PCFKALRERL 441
            |.|:.:...|
  Fly   391 PSFRQILSHL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781
		SH2_PTK6_Brk	75..174	CDD:198221
		Linker	171..190		3/7 (43%)
		PTKc_Srm_Brk	184..444	CDD:133248	85/268 (32%)
		STYKc	192..441	CDD:214568	81/258 (31%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	81/259 (31%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	81/255 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910