DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTK6 and src-2

DIOPT Version :9

Sequence 1:	NP_005966.1	Gene:	PTK6 / 5753	HGNCID:	9617	Length:	451	Species:	Homo sapiens
Sequence 2:	NP_493502.1	Gene:	src-2 / 173296	WormBaseID:	WBGene00005078	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	184/443 - (41%)
Similarity:	272/443 - (61%)	Gaps:	13/443 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    13 YVGLWDFKSRTDEELSFRAGDVFHVARKEE-QWWWATLLDEAGGAVAQGYVPHNYLAERETVESE 76
            :|.|:.:.:|||::|||:..|:..:....: .||:|.  .:|.|..  ||:|.||:|..:::||:
Worm    62 FVALFQYDARTDDDLSFKKDDILEILNDTQGDWWFAR--HKATGRT--GYIPSNYVAREKSIESQ 122

Human    77 PWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNE 141
            ||:||.:.|.:|.:.|....|..||||:|.||....|..||||:..:|:||:|.:...|...:..
Worm   123 PWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYFIAR 187

Human   142 AVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHE-PE--PLPHWDDWERPREEFTLCRKLGSGYFG 203
            ...|.:|.:|:.:::.::....:.|.|||.|.| |:  ...:.|.||..|....|.|::|:|.||
Worm   188 RRPFATLHDLIAHYQREADGLCVNLGAPCAKSEAPQTTTFTYDDQWEVDRRSVRLIRQIGAGQFG 252

Human   204 EVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMA 268
            ||:||.|...|.||:|.:..........| :|.|.||||||..:|:||||.:..:|:.|:||||.
Worm   253 EVWEGRWNVNVPVAVKKLKAGTADPTDFL-AEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQ 316

Human   269 KGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGL 333
            :..|..|.|...:..:|  :|::|:.|||.||.|||..|:|||||||||||:..:...|:.||||
Worm   317 ENLLTFLQRRGRQCQMP--QLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGL 379

Human   334 AR-LIKEDVYLSH-DHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEA 396
            || |:||:.|.:. ....|.|||||||.:...::||||||||||||.|:.:.|::|||||:|.|.
Worm   380 ARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEV 444

Human   397 FLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYEN 449
            ..:||||||||||..||.:::.:|..||..||::||.|:.|:.:|....:.::
Worm   445 LQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLFNLDS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTK6	NP_005966.1	SH3_Brk	12..69	CDD:212781	19/56 (34%)
		SH2_PTK6_Brk	75..174	CDD:198221	34/98 (35%)
		Linker	171..190		7/21 (33%)
		PTKc_Srm_Brk	184..444	CDD:133248	126/261 (48%)
		STYKc	192..441	CDD:214568	122/250 (49%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	17/53 (32%)
		SH2_Src_Src42	120..215	CDD:198233	31/94 (33%)
		PTKc_Frk_like	231..496	CDD:270653	127/267 (48%)
		Pkinase_Tyr	240..489	CDD:285015	122/251 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820