Protein Alignment STARD9 and klp8

DIOPT Version :10

• Sequence 1: XP_011520133.1
• Gene: STARD9 / 57519
• HGNCID: 19162
• Length: 4705
• Species: Homo sapiens
• Sequence 2: NP_594675.1
• Gene: klp8 / 2542849
• PomBaseID: SPAC144.14
• Length: 511
• Species: Schizosaccharomyces pombe
• Alignment Length: 534
• Identity: 142/534 - (26%)
• Similarity: 227/534 - (42%)
• Gaps: 148/534 - (27%)

Human     2 ANVQVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRP--DGFGDSREK-----VMAFGF 59
            |||:|.|||||.|.||..:....::.||.     .|..|...|  .|...||.|     ...|.|
pombe     4 ANVRVIVRVRPKSLRELSKSAEDLLSVDS-----HNKTVTITPPKHGLKHSRHKNRVNGPRTFAF 63

Human    60 DYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPASVGLTP 124
            |.|:....||....:.|:.|::..|..::..:.:|:|.|...|||.|:||||:::|.....|:.|
pombe    64 DECFAPSAPESKNLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGLRGQPGIIP 128

Human   125 RICEGLF-----VREKDCASLPSSCRIKVSFLEIYNERVRDLLK---QSGQKKSYTLRVREHPEM 181
            .|.|.:|     :::|   |..::..:.:|..||..|...|||:   .|......|:.|::....
pombe   129 HISESIFEEIDKLKKK---SPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLT 190

Human   182 GPYVQGLSQHVVTNYKQV---IQLLEEGIANRITAATHVHEASSRSHAIFTIHYTQAILENNLPS 243
            |.::.|||:..|.:.:::   ::|..:.|...::..:.|.    :.|::|::...|.|::.....
pombe   191 GYHLHGLSEFEVGSAQEIDAFLRLAAKNIRTELSDISGVR----KGHSVFSLVVQQRIIDPKTRH 251

Human   244 EM--ASKINLVDLA----GSERADPSYCKDRIA--EGANINKSLVTLGIVISTLAQNSQVFSSCQ 300
            .:  ||::.::|||    ||:|      .:.|:  |.::.||||..|..||:.|..
pombe   252 SLKKASRLQIIDLASFSKGSQR------NESISSFESSSNNKSLSVLNRVIAALTS--------- 301

Human   301 SLNSSVSNGGDSGILSSPSGTSSGGAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAH 365
                                       .:....|||:|||||.||:|:||||.:|||:..|||.
pombe   302 ---------------------------KKNDVLIPYKDSVLTTLLQDALGGNCRTIMLTCVSPC- 338

Human   366 TSYSETMSTLRYASSAKNIINKPRVN------------------------------EDAN---LK 397
             .:.:|.|.|||:.:|:.|.|...:|                              |:.:   ||
pombe   339 -DFDDTFSALRYSEAARRIKNISNINCKEAYSTNNEGELDDILTTLESDREQLRRHEEHSQKLLK 402

Human   398 LIRELREEI-ERLKAL-----LLSFELR------------NFSSLSDENLK-------ELVLQNE 437
            .|.|:|.:. ||:.||     .|...||            ||   .|:|:|       .:..:.|
pombe   403 FIEEIRNDYEERIHALESQNSALKAHLRLAVDAYLNPLEFNF---DDKNVKLKEFGSPNIAYKQE 464

Human   438 L-----KIDQLTKD 446
            |     ::..|.||
pombe   465 LNSFQGELSSLFKD 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STARD9	XP_011520133.1	KISc_KIF1A_KIF1B	2..391	CDD:276816	118/414 (29%)
		Kinesin_assoc	390..501	CDD:465047	24/120 (20%)
		FHA_KIF16A_STARD9	471..589	CDD:438783
		COG4913	<580..>786	CDD:443941
		START_STARD9-like	4496..4705	CDD:176883
klp8	NP_594675.1	KISc	5..354	CDD:276812	114/404 (28%)