Protein Alignment MTA3 and MTA1-like

DIOPT Version :10

• Sequence 1: NP_001317371.1
• Gene: MTA3 / 57504
• HGNCID: 23784
• Length: 594
• Species: Homo sapiens
• Sequence 2: NP_001262293.1
• Gene: MTA1-like / 40693
• FlyBaseID: FBgn0027951
• Length: 922
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 327/763 - (42%)
• Similarity: 426/763 - (55%)
• Gaps: 186/763 - (24%)

Human     1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKE 65
            ||.||||||||||.|.:.::||||||||||||..:|||||||:|||||||:.|.|:.|||||...
  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65

Human    66 IEEES-----------ETTVEAD------------------------------------------ 77
            ..|:|           .|.|..:
  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130

Human    78 -----------------------------LTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVAL 113
                                         ||.||::|:||||||||||.||:|||.|||||||.|
  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195

Human   114 LNETESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLE 178
            ||||||:.|||:|:|||||.||:||:.|||||||||||||.|||.|||..|.:..:|:|:..:||
  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260

Human   179 VKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYR 243
            ..||.|...||||:|||||||:|::|||||||||||||:|||||||||||||||||||||:.|::
  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325

Human   244 HSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIE 308
            |.|.:..::|.|||..||||||||:|:||||||:||||||||||||||||||||||||:|..|||
  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390

Human   309 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAV-GTTFQPQN 372
            ||||||||||||||||:||.|||.||||||||.|:.......:::....|..||.. |:|....|
  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSN 455

Human   373 PLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEK----------- 426
               |:.||||..|:|.||.|....:...|||..||.||::||.:|..|:.:..:
  Fly   456 ---GKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAA 517

Human   427 ---------LSPSPT-----TEDPRV----------------------RSHVSRQAMQ--GMPVR 453
                     |:.:||     .:|.::                      ::|::|...|  |:.:
  Fly   518 STPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAI- 581

Human   454 NTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADR-----H 513
            ::|||:..:|||.||:|||...|:.||.:|::.::.::|||:...|||...::.|:.:|     .
  Fly   582 SSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQ 646

Human   514 AELS--------------------GSP--------LKSKSTRKPLACIIGYLEIHPAKKPN---- 546
            ||:.                    |:|        :.:...:.||..::.:.:  |.|.|:
  Fly   647 AEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPK--PPKAPDGSLV 709

Human   547 ---VIRSTPS-LQTPTTKRMLTTPNHTSLSILGKRNYSHH----NGLD 586
               |...:|. :..|..|.:...|...:.:|   |..:|.    ||.:
  Fly   710 YDRVPNKSPDVVAVPADKELTIIPTQATSTI---RKRAHEDQQLNGTE 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTA3	NP_001317371.1	BAH_MTA	3..170	CDD:240060	115/248 (46%)
		ELM2	150..201	CDD:460214	29/50 (58%)
		SANT_MTA3_like	270..315	CDD:212559	39/44 (89%)
		ZnF_GATA	376..425	CDD:214648	21/48 (44%)
		MTA_R1	461..537	CDD:465388	26/108 (24%)
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	115/249 (46%)
		ELM2	232..284	CDD:460214	29/51 (57%)
		SANT_MTA3_like	352..397	CDD:212559	39/44 (89%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
		MTA_R1	589..670	CDD:465388	22/80 (28%)