Protein Alignment NLGN4X and nlgn4xa

DIOPT Version :10

• Sequence 1: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 853
• Identity: 694/853 - (81%)
• Similarity: 756/853 - (88%)
• Gaps: 26/853 - (3%)

Human     1 MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNE 65
            |||.:|..|:||  |.|..:....:..|: .||..:..|....|:|:|.|||||:|||:||||||
Zfish     1 MSRLRGTPWIPL--TMVHPLATLRLFTWI-VLAAAWLAITWAQQHPIVTTNYGKLRGLKTPLPNE 62

Human    66 ILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTA 130
            ||||||||||:|||.||||||||||||||.||.||||.||||.||||.|::|.||:||||:||||
Zfish    63 ILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTA 127

Human   131 NLDTLMTYVQDQNEDCLYLNIYVPTED-GANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHG 194
            ||||::||||||:|||||||||||||| |||   ..||.|:|:.||::||||:|..:||||||||
Zfish   128 NLDTVVTYVQDQSEDCLYLNIYVPTEDVGAN---KGDDFTNNEGGENKDIHDENGLRPVMVYIHG 189

Human   195 GSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVG 259
            ||||||||||||||||||||||||:|:|||||:|||||||||||||||||||||||||||:||:.
Zfish   190 GSYMEGTGNMIDGSILASYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWIKENIQ 254

Human   260 AFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKV 324
            ||.||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||:||
Zfish   255 AFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKV 319

Human   325 GCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIML 389
            ||||||:.|:||||:||||||||:|.||.|.||||||||||||||||||||||||||||||||||
Zfish   320 GCNMLDSIDLVECLQNKNYKELIEQYITQAKYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIML 384

Human   390 GVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPE 454
            |||||||.||||||||:||||:.|||||:||:|||:|||||||||||||||||||||||||||||
Zfish   385 GVNQGEGFKFVDGIVDSEDGVSANDFDFAVSDFVDHLYGYPEGKDTLRETIKFMYTDWADKENPE 449

Human   455 TRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGI 519
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish   450 TRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWSDSAHGDEVPYVFGI 514

Human   520 PMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNP 584
            ||:|||:||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   515 PMLGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNP 579

Human   585 KDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSP 649
            |||||||||||||||||||||||||||||||||||:||:|||||||||:||.|.|.||| |:|.
Zfish   580 KDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNINELFQYVSTTTKIPPQDTTPFPY-TKRL- 642

Human   650 AKIWP-TTKRPAITPANNPKHSKDPHKTG--PEDTTVLIETKRDYSTELSVTIAVGASLLFLNIL 711
            .|.|| ||:.|.:.|||. |.:.|..|..  .:|:.|:|||||||||||||||||||||||||||
Zfish   643 GKTWPSTTRHPGVPPANT-KQTTDQRKGNDLSDDSAVVIETKRDYSTELSVTIAVGASLLFLNIL 706

Human   712 AFAALYYKKDKRRHETHRR-PSPQRNT--------TNDIAHIQNEEIMSLQMKQL----EHDHEC 763
            |||||||||||||||::|| ||||||:        .|||||:|::|:|||||||.    ||.|||
Zfish   707 AFAALYYKKDKRRHESNRRGPSPQRNSAPANVVANANDIAHLQSDELMSLQMKQQQMEHEHHHEC 771

Human   764 ESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNLP 828
            :|||||||||||||.||||||||||||||||||:|||||||||.|||.||.||||.|.|||||||
Zfish   772 DSLQAHDTLRLTCPADYTLTLRRSPDDIPLMTPSTITMIPNTLAGMQTLHNFNTFGGSQNSTNLP 836

Human   829 HGHSTTRV 836
            ||||||||
Zfish   837 HGHSTTRV 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	502/566 (89%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	501/564 (89%)