Protein Alignment NLGN4X and Nlg3

DIOPT Version :10

• Sequence 1: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 288/916 - (31%)
• Similarity: 422/916 - (46%)
• Gaps: 216/916 - (23%)

Human    39 IDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNT 103
            :.:|....::||..|.|.|:...|....|.|||.|.|:||||||.|..||.||...:.|:|::..
  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKA 213

Human   104 TQFAAVCPQHLDERSLLH------DMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTE------ 156
            .:|:.||||.|.:   :|      :.:|......|..|:.|:|:|:|||||||||||.:
  Fly   214 DRFSPVCPQRLPD---IHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDS 275

Human   157 DGANTKKNADDITSNDRGEDEDIHDQN-----------SKKPVMVYIHGGSYMEGTGNMIDGSIL 210
            .|:::..:|...:|...|........:           :|.||:|::||.||...:||..|||:|
  Fly   276 SGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVL 340

Human   211 ASYGNVIVITINYRLGILGFLSTG-DQAAK--GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFG 272
            ||||.::|:|||||||:||||:.. |:.:|  .||||:|.|.||.|::||:.||||||..:|:.|
  Fly   341 ASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAG 405

Human   273 SGAGASCVSLLTLS-HYSEG-LFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGC-NMLDTTDM 334
            .|.||:||..|..| ...|| ||.:||:.||:.|:.|::...||||..|:|..|.| :.|....:
  Fly   406 HGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHL 470

Human   335 VECLRNKNYKELIQQTITPATYHIAFGPVIDGDVI---------PDDPQ---------------- 374
            ::|||.|...:|:...|.|..:..||||.|||.||         |..|.
  Fly   471 MKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG 535

Human   375 --------------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVDGIVDNEDGVTPNDF 415
                                :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:..:..
  Fly   536 GEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIEADRR 598

Human   416 DFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADKENP-----ETRRKTLVALFTDHQWVAP 472
            ...:..:|.|.|.:     .|.|   ||...||||   |.|     ..|.:||.|| :|.|.|||
  Fly   599 SRILKAYVRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAP 654

Human   473 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDV 537
            |..|.|||:.....:|.|.|.:..:....|......||:::||:||.|::|....|:.|::|.::
  Fly   655 AAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEI 719

Human   538 MLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWSKYNPKDQLYLHIGLKPRVR 599
            .||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||:::
  Fly   720 SLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLK 780

Human   600 DHYRATKVAFWLELVPHLHN--------------------------------------------- 619
            :||||.:::|||.|:|.||.
  Fly   781 NHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAA 845

Human   620 -------LNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTG 677
                   .|::|..::.::    |..:....|||....||:|......            .|..|
  Fly   846 MANFTIFTNQVFSLLNLSS----PSSSLQRNGTRYGGGKIYPDDMMDG------------DHAGG 894

Human   678 PEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQ-------- 734
            ....:...:....|||.||||||:|.|||.||:|.||.:||::||.|..   .|.||
  Fly   895 AASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLS---EPRPQTKLKRQEN 956

Human   735 ----RNTTNDIAHIQNEEIMSLQMKQ-----LEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790
                .|...|:      |.:::..|.     |.|.|   ::|.|.    ..||::.        |
  Fly   957 GQMPNNICGDL------ETLTIHAKSDPATILSHHH---AMQHHQ----LPPPEFA--------D 1000

Human   791 IPLMTP 796
            ||...|
  Fly  1001 IPHRAP 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	228/654 (35%)
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	228/654 (35%)