Protein Alignment NLGN4X and Nlgn4l

DIOPT Version :10

• Sequence 1: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Sequence 2: NP_001423254.1
• Gene: Nlgn4l / 100113365
• MGIID: 3775191
• Length: 945
• Species: Mus musculus
• Alignment Length: 954
• Identity: 556/954 - (58%)
• Similarity: 640/954 - (67%)
• Gaps: 166/954 - (17%)

Human    32 LAIKFTLIDSQAQ------YPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQP 90
            |.:...|..:|..      :|||.|||||:||:|..||.::||||.|:||||||:||||||||||
Mouse     9 LCLALALASAQPSPPPPPPFPVVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQP 73

Human    91 PEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPT 155
            |||||||.|:|:.|:||.|||||||||:||.|.||.||.||||.:..|||||:|||||||:|||
Mouse    74 PEPPSSWAGVRDATRFAPVCPQHLDERALLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVP- 137

Human   156 EDGANTKKNADDITSNDRGEDEDIHDQN--------SKKPVMVYIHGGSYMEGTGNMIDGSILAS 212
             .|||.||.|||:|.||.|:|:|..|..        ::||||||||||||||||.|::|||:|||
Mouse   138 -GGANGKKMADDVTGNDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLAS 201

Human   213 YGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGA 277
            ||:|||:|:|||||:||||||||||||||||||||||||||:|||.|||||||.|||:|||||||
Mouse   202 YGDVIVVTVNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGA 266

Human   278 SCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNM------------LD 330
            |||||||||||||||||||||||||||||||||||||:|.|.|.::|||..            .|
Mouse   267 SCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWD 331

Human   331 TTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGE 395
            :..:|.|||.|...||.:..:||||||:||||.:|||||||||||||||||||||||||||||||
Mouse   332 SASLVSCLRGKAAGELARARVTPATYHVAFGPTVDGDVIPDDPQILMEQGEFLNYDIMLGVNQGE 396

Human   396 GLKFVDGIVDNED-----------------------------GVTPNDFDFSVSNFVDNLYGYPE 431
            |.:||||:....|                             ||:..:||.:||.|:::|||.||
Mouse   397 GARFVDGLGGGHDGGYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPE 461

Human   432 GK-DTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHH 495
            |: |.||||:|||||||||:::||.||||||||||||||||||||||||||:||||||||||||.
Mouse   462 GRGDALRETVKFMYTDWADRDSPEARRKTLVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHR 526

Human   496 CQ----------------------SEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVM 538
            |.                      .|.:|:|||:|||||||||||:||.||.::|.||||:||||
Mouse   527 CHGGGGGGGGVDGVAGGVAGGVGGEEARPAWADAAHGDEVPYVFGVPMAGPGDVFGCNFSRNDVM 591

Human   539 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYR 603
            ||||||||||||||||||||||.|||:|:||:|||||||||:||:|:.||||||||:||||||||
Mouse   592 LSAVVMTYWTNFAKTGDPNQPVAQDTRFVHTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYR 656

Human   604 ATKVAFWLELVPHLHNLNE---IFQYVSTTTKVPPPDMTSFP---YGTRRSPAKIWPTTKRPAIT 662
            |.|||||||||||||.|..   .:...:.|...|..|....|   .|.||.|.   |.|:|||:.
Mouse   657 AAKVAFWLELVPHLHGLAADPGAYLSAAATRAAPSGDPDRDPGGGGGGRRRPR---PATRRPAVM 718

Human   663 PAN---------NPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYY 718
            .::         :...|.....:|...:.|||||:|||||||||||||||||||||:||||||||
Mouse   719 TSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAVGASLLFLNVLAFAALYY 783

Human   719 KKDKRRHETHRRPSP-------------QRNTTNDIAHIQNEEIMSLQMKQLEHDHECESL---- 766
            |||||||||||||.|             .||...|.....            ....||.::
Mouse   784 KKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAG------------RRGGECGAVVTAM 836

Human   767 --------QAHD---------------TLRLTCPPDYTLTLRRSPDDIPL--MTPNTITMIPNTL 806
                    ..||               .|||.|||||.|||||||||:|.  ..|..:|:||..|
Mouse   837 AAEASAGGLGHDGVGGVGVGGVIGGVAGLRLACPPDYALTLRRSPDDVPRAGAGPGAMTLIPGAL 901

Human   807 --TGMQPLHTFNTFSGG------------QNSTNLPHGHSTTRV 836
              .|...:|.||||..|            |....||||||||||
Mouse   902 GGGGGGAVHGFNTFGSGVGVAGVAGVATSQAGPGLPHGHSTTRV 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	431/643 (67%)
Nlgn4l	NP_001423254.1	COesterase	30..663	CDD:395084	430/634 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..167		10/21 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..742		14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..828		14/52 (27%)