Protein Alignment ADGRB1 and Adgrb1

DIOPT Version :9

• Sequence 1: XP_016869180.1
• Gene: ADGRB1 / 575
• HGNCID: 943
• Length: 1663
• Species: Homo sapiens
• Sequence 2: XP_038935459.1
• Gene: Adgrb1 / 362931
• RGDID: 1305608
• Length: 1615
• Species: Rattus norvegicus
• Alignment Length: 1663
• Identity: 1520/1663 - (91%)
• Similarity: 1554/1663 - (93%)
• Gaps: 48/1663 - (2%)

Human     1 MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANA 65
            ||||||||||:|||||||||||||||.||||:|||.|||.|.|.|||||||||||||||||||||
  Rat     1 MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAVFPANA 65

Human    66 SRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPS 130
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat    66 SRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPS 130

Human   131 APLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDA 195
            |||||||||||||||:||||||...|    ||.|..||||||||||||||||.||||||||||||
  Rat   131 APLAFLQASKQFLQMQRQQPPQDGDL----GPQGSGDDFSVEYLVVGNRNPSHAACQMLCRWLDA 191

Human   196 CLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGA 260
            ||||||||||||||||||||||||||..|:.||.|||||||||.||||||||||||||||||||:
  Rat   192 CLAGSRSSHPCGIMQTPCACLGGEAGDTASSPLVPRGDVCLRDGVAGGPENCLTSLTQDRGGHGS 256

Human   261 TGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQ 325
            .|||||||||||||||||||||||||||.|..||||.||||||||||.|||:||||.||||||||
  Rat   257 AGGWKLWSLWGECTRDCGGGLQTRTRTCSPTLGVEGRGCEGVLEEGRLCNRKACGPTGRTSSRSQ 321

Human   326 SLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQC 390
            ||||||||||||.||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   322 SLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQC 386

Human   391 SGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKF 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   387 SGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKF 451

Human   456 CNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 520
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
  Rat   452 CNIALCPGRAVDGNWNEWSSWSTCSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 516

Human   521 VDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDN 585
            |||||||||||||||||||.||||||||||||||||||||||||||||||.||||||||||||||
  Rat   517 VDGKWQAWASWGSCSVTCGGGSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDN 581

Human   586 FGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHL 650
            ||||:||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||
  Rat   582 FGAVVWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHL 646

Human   651 AKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQI 715
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   647 AKAQRGLPGEGVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQI 711

Human   716 LSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG 780
            :|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
  Rat   712 ISNLLAEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG 776

Human   781 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNT 845
            ||||||||||||||||||||||||||||||||||||.|||::|||||||||||||||||||||||
  Rat   777 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLALQRNT 841

Human   846 TVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCR 910
            |||||||||||||||||||.||||||||||||||||||||||||||.||||||||||||||||||
  Rat   842 TVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPSSSAPPQLGPWSWRGCR 906

Human   911 TVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRY 975
            |||||||||||||||||||||||||||||.|:|.|:|||||||||||||||||||||||||||||
  Rat   907 TVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTVPSVTLIVGCGVSSLTLLMLVIIYVSVWRY 971

Human   976 IRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAV 1040
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   972 IRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAV 1036

Human  1041 TGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLV 1105
            ||.||:||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1037 TGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLV 1101

Human  1106 NMVIGILVFNKLVSKDGITDKKLKERAGQPSPHPLGRALKCAECGVLSAADATSDATSNAMASLW 1170
            |||||||||||||||||||||||||||||....||||||.||||||||||:||||||||||||||
  Rat  1102 NMVIGILVFNKLVSKDGITDKKLKERAGQLPVPPLGRALTCAECGVLSAAEATSDATSNAMASLW 1166

Human  1171 SSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDR 1235
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1167 SSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDR 1231

Human  1236 QEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSGPEAVTGSGFLSCGEANGPCSLWSFRYLKSTF 1300
            |||||||||||||||||||||||||||||||||| |.:|
  Rat  1232 QEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSG-ERLT-------------------------- 1269

Human  1301 SRDSPGRGAGTAPVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLH 1365
                         |||||||||||||||||.||||||||||:||  |||||..||||||||||||
  Rat  1270 -------------VLNKDIAACRTATITGTFKRPSLPEEEKMKL--AKGPPPTFNSLPANVSKLH 1319

Human  1366 LHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTAT 1430
            |||||||||||||||||||||||:||||||||:||||||||||||||||||||||||||||||||
  Rat  1320 LHGSPRYPGGPLPDFPNHSLTLKKDKAPKSSFIGDGDIFKKLDSELSRAQEKALDTSYVILPTAT 1384

Human  1431 ATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPP 1495
            |||||||||||||||:|||||||||||||.||:||.|.||||:|:||.|.|||.||.| ||||||
  Rat  1385 ATLRPKPKEEPKYSINIDQMPQTRLIHLSMAPDASFPTRSPPAREPPGGAPPEVPPVQ-PPPPPP 1448

Human  1496 PPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDF 1560
            ||||||||:||||:||||||||||.|||:||||||:|..||||||||||||||||||||||||||
  Rat  1449 PPPPPQQPIPPPPSLEPAPPSLGDTGEPSAHPGPSSGAGTKNENVATLSVSSLERRKSRYAELDF 1513

Human  1561 EKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKQPEKQQTPNKRPWESLRKAHGTPTWVKK 1625
            |||||||||||||||||||||||||||:|||.|.|:| ||||||||||.||||||.||||.||||
  Rat  1514 EKIMHTRKRHQDMFQDLNRKLQHAAEKEKEVPGVDNK-PEKQQTPNKRAWESLRKPHGTPAWVKK 1577

Human  1626 ELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV 1663
            |||||.||||||||||||::||||||||||||||||||
  Rat  1578 ELEPLPPSPLELRSVEWEKAGATIPLVGQDIIDLQTEV 1615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRB1	XP_016869180.1	None
Adgrb1	XP_038935459.1	AGRB_N	43..216	CDD:408958	162/176 (92%)
		TSP1	260..310	CDD:214559	43/49 (88%)
		TSP1	355..403	CDD:214559	47/47 (100%)
		TSP1	408..458	CDD:214559	49/49 (100%)
		TSP1	466..516	CDD:214559	48/49 (98%)
		TSP1	521..571	CDD:214559	47/49 (96%)
		HormR	573..639	CDD:214468	63/65 (97%)
		GAIN	657..855	CDD:406802	191/197 (97%)
		GPS	876..934	CDD:197639	56/57 (98%)
		7tmB2_BAI_Adhesion_VII	941..1230	CDD:320379	278/288 (97%)
		TM helix 1	943..967	CDD:320379	23/23 (100%)
		TM helix 2	977..998	CDD:320379	20/20 (100%)
		TM helix 3	1008..1030	CDD:320379	21/21 (100%)
		TM helix 4	1048..1064	CDD:320379	15/15 (100%)
		TM helix 5	1084..1107	CDD:320379	22/22 (100%)
		TM helix 6	1165..1187	CDD:320379	21/21 (100%)
		TM helix 7	1192..1217	CDD:320379	24/24 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	758	1.000	Domainoid score	I3015
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1287
Inparanoid	1	1.050	3092	1.000	Inparanoid score	I484
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41304
OrthoDB	1	1.010	-	-		D11632at32523
OrthoFinder	1	1.000	-	-		FOG0010992
OrthoInspector	1	1.000	-	-		oto139833
orthoMCL	1	0.900	-	-		OOG6_105378
Panther	1	1.100	-	-	LDO	PTHR12011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X8565
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	15.480