DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRB1 and Cirl

DIOPT Version :9

Sequence 1:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens
Sequence 2:	NP_001260807.1	Gene:	Cirl / 35846	FlyBaseID:	FBgn0033313	Length:	1711	Species:	Drosophila melanogaster

Alignment Length:	1238	Identity:	257/1238 - (20%)
Similarity:	418/1238 - (33%)	Gaps:	334/1238 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   533 SCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAG 597
            |.||..|.||.  .|..:......|...|..||.:.           .|...:...:.|..|..|
  Fly   295 SGSVVPGNGSV--VRTINNINLNAAGMSGGDDESKL-----------FCGPTHARNLYWNMTRVG 346

Human   598 EVAAVRCPRNATGLILRRC------------ELDEE------------------------GIAY- 625
            :|....||..|.|:...||            |.|::                        .:|:
  Fly   347 DVNVQPCPGGAAGIAKWRCVLMKRIPDSGYDEYDDDISSTTPAPSGGDCLHNSSSCEPPVSMAHK 411

Human   626 -----------WEP--PTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGT 677
                       |.|  |...:|.|:...|::|...:.         ...:..:...:.|::...|
  Fly   412 VNQRLRNFEPTWHPATPDLTQCRSLWLNNLEMRVNQR---------DSSLISIANDMSEVTSSKT 467

Human   678 SYSGDLLSTIDVLRNMTEIFRRAYYSPT-PGDVQNFVQIL----------SNLLAEENRDKWEEA 731
            .|.||:|.|..:::.::|  :..:...| |...|....|:          ||||.|.....|.:.
  Fly   468 LYGGDMLVTTKIIQTVSE--KMMHDKETFPDQRQREAMIMELLHCVVKTGSNLLDESQLSSWLDL 530

Human   732 QLAGPNAKELFRLVEDF---VDVIGFRMKDL----RDAYQVTDNLVLSIHKLPASG-ATDISFP- 787
                 |.::..|:....   ::...|.:.|.    |...|...|::||:..|.... .:.:.||
  Fly   531 -----NPEDQMRVATSLLTGLEYNAFLLADTIIRERSVVQKVKNILLSVRVLETKTIQSSVVFPD 590

Human   788 MKGWRATGDWAKVPE-------------------DRVTVSKSVFSTGLTEAD--EASVFVVGTVL 831
            ...|..:.|..::|.                   ||:   :|:........|  .:..:|..|.:
  Fly   591 SDQWPLSSDRIELPRAALIDNSEGGLVRIVFAAFDRL---ESILKPSYDHFDLKSSRSYVRNTAI 652

Human   832 YRNLGSFLA--LQRNTTVLNSKVISVTV-KPPPRSLRTPLEIEFAHM-YNGTTNQTCILWDETDV 892
            ..|.....|  :|:...:|||||||.:: |.....|..|:.:...|: ....||.||:.|:..|
  Fly   653 LSNDSDVNAGEIQQRLRILNSKVISASLGKGRHIQLSQPITLTLKHLKTENVTNPTCVFWNYID- 716

Human   893 PSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQL----------SADANMEKATLP 947
                     ..||..||.....:...:.|.|:.|:.||||..:          ..|.||.
  Fly   717 ---------HAWSANGCSLESTNRTHSVCSCNHLTNFAILMDVVDEHQHSLFTMFDGNMR----- 767

Human   948 SVTLIVGCGVSSLTLLMLVIIYVSVWR--YIRSERSVILINFCLSIISSNALILIGQTQTRNKVV 1010
             :.:.:..|: .:..:::.::.:.::.  :::|.|:.|..:..|.:::...|.|:|..||...:.
  Fly   768 -IFIYISIGI-CVVFIVIALLTLKLFNGVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSIF 830

Human  1011 CTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRK--------RFLCLGWGLPALVVAI 1067
            |..:..|||...||...|...||:.||..:|.   :.|:.:        .:..|.:||...||||
  Fly   831 CGFITIFLHCAILSGTAWFCYEAFHSYSTLTS---DELLLEVDQTPKVNCYYLLSYGLSLSVVAI 892

Human  1068 SVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKK----- 1127
            |:....:. |:..:||.|.....|.||           ..||.:|||  .|:..|.|...
  Fly   893 SLVIDPST-YTQNDYCVLMEANALFYA-----------TFVIPVLVF--FVAAIGYTFLSWIIMC 943

Human  1128 LKERAGQPSPHPLGRALKCAECGVLSAADATSDATSNAMASLWSSC--VVLPLLALTWMSAVL-- 1188
            .|.|.|          ||            |.:.|..|.......|  |.|.||:..|.||..
  Fly   944 RKSRTG----------LK------------TKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYL 986

Human  1189 ---AVTDRRSALFQILFAVFDSLEGFVIVMVHCI----LRREVQDAVKCRVVDRQEEGNGDSGGS 1246
               .:.|..:.::...|..|::|.|..|.:.|||    :|||.:..|      ||
  Fly   987 RGAKMDDDTADVYGYCFICFNTLLGLYIFVFHCIQNEKIRREYRKYV------RQ---------- 1035

Human  1247 FQNGHAQLMTDFEKDVDLACRSGPEAVTGSGFLSCGEANGP-----CSLWSFRYLK-----STFS 1301
                ||.|.         .|....:....||.::   .|||     ||:.:.:..|     |..:
  Fly  1036 ----HAWLP---------KCLRCSKTSISSGIVT---GNGPTAGTLCSVSTSKKPKLPLGVSEEA 1084

Human  1302 RDSPGRGAGTAPVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHL 1366
            .|.|.:...|...:.:|       .|.|......|.|.::.:            :|.:.:....|
  Fly  1085 HDDPQQQQQTPVPITED-------AIMGATSDCELNEAQQRR------------TLKSGLMTGTL 1130

Human  1367 HGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATA 1431
            ...|:..||.:......:|......:|.|| .|...:......:..:.|:..|..||.
  Fly  1131 QAPPQTLGGHVVLERGSTLRSTGHASPTSS-AGSTHLIFAHKQQQQQQQQGPLGESYY------- 1187

Human  1432 TLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPE----ASLPARSPP--------SRQPPSG--GPP 1482
                   .:|.|  :..:.|.|....|.|..|    |...|.||.        :::|.||  |..
  Fly  1188 -------HQPDY--YSWKQPSTGTGGLKTPREYYNNAGAAASSPQQAHEVFYWTQKPNSGHNGKK 1243

Human  1483 E----APPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHP--GPSTGPSTKNENVA 1541
            :    ..||.|............|.|..|...:.      .||:|..:|  ..:..|.....|.|
  Fly  1244 KRGAGGVPASPSGSLHSRTAAASQVLFYPSYKKT------KPGQPTGYPQYAEALDPPLATGNAA 1302

Human  1542 TLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKQPEKQQTPN 1606
            .......:.|:.:         :|.:::.|.. |.|:.. :..||:...:|....:...:||.|.
  Fly  1303 AYYQQQQQLRRQQ---------LHQQQQQQQQ-QQLSSD-EEQAEQHAHLLHLQRRAGSQQQLPA 1356

Human  1607 KRP 1609
            ..|
  Fly  1357 PPP 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRB1	XP_016869180.1	None
Cirl	NP_001260807.1	Gal_Lectin	33..113	CDD:280328
		GAIN	453..680	CDD:293098	49/236 (21%)
		GPS	705..752	CDD:197639	17/56 (30%)
		7tm_4	763..1014	CDD:304433	70/296 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010