DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRB1 and adt-3

DIOPT Version :9

Sequence 1:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens
Sequence 2:	NP_508681.3	Gene:	adt-3 / 180675	WormBaseID:	WBGene00020567	Length:	940	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	133/543 - (24%)
Similarity:	174/543 - (32%)	Gaps:	222/543 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   186 CQMLCRWLDACLAGS---RSSHP------CGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVA 241
            |||:  |   |..|.   |::||      ||.                       |.:|.:....
Worm   466 CQMV--W---CGNGEGVIRTAHPALEGTYCGF-----------------------GMICRQGQCV 502

Human   242 GGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGG-----------GLQTRTRTC-LPAPGV 294
            |..:  |..:|        .|||..|:  ......|||           .:....|.| .|:...
Worm   503 GSSQ--LMRVT--------VGGWSTWN--DRPAPTCGGRCSQCEIRGQIRIMRSIRQCNNPSSNN 555

Human   295 EGGGCEGVLEEGRQCNREACGP------AGRTSSRSQSLRSTDARRREELGDELQQF-------- 345
            .|..|:|....|..|:|:.|..      |.|..||   ||..:|.....|..|..||
Worm   556 GGAPCQGDEARGMVCHRDVCNGDSIENYATRVCSR---LRDENAIPNTILSGEGMQFEQAMCKIW 617

Human   346 -------------GFP--AP----------------------------------QT--------- 352
                         .||  ||                                  ||
Worm   618 CLISGSTNIRTVSNFPDGAPCGPGQYCIKGECRPLLCGSTTLAYSEADCPLSVLQTTTTPPMPHV 682

Human   353 -----------------GDPAAEEWSPWSVCSS----TC-GEGWQTRTRFCVSSSYSTQCSGPLR 395
                             ..|...|||.|||.|.    .| .:|.:.|.|.|::.    .|:|.||
Worm   683 HSVDQFAGKTNPYKEHKKTPFLNEWSGWSVWSECVTYDCHTQGVKVRVRRCLAG----VCAGALR 743

Human   396 EQRLC--------------------NNSAVCPVHGAW--------DEWSPWSLCSSTCGRGFRDR 432
            |::.|                    .|..:.|:....        |.|.|||.||.|||.|.:.|
Worm   744 ERQPCTRPCTGSERPLTTSPPQQTFRNRFIAPLPNRQTNMILRKVDHWGPWSACSVTCGTGQKLR 808

Human   433 TRTCRPPQFGGNPCEGPE-KQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNG 496
            .|         ..|.|.| .:|..|.:..|  |.....|.|||.||.||.:|.:|.|.|.|.|
Worm   809 RR---------ENCIGQECAETGPCVMQSC--RENKNTWTEWSQWSDCSVNCGEGVQFRKRAC-- 860

Human   497 PSYGGAECQGHWVETRDCFLQQC-------PV---DGKWQAWASWGSCSVTCGAGSQRRERVCSG 551
               ..|.|:|...:.|:|:.|:|       |:   .|.|..|:||.|||..||.|.:.|.|.|
Worm   861 ---FAAFCRGKDSDVRNCYGQRCSETTTRRPLVNRSGLWTGWSSWSSCSTKCGIGQRTRRRRC-- 920

Human   552 PFFGGAACQGPQDEYRQCGTQRC 574
              :.| :|.|..:|..:|...:|
Worm   921 --YQG-SCLGDDNEKERCIGSQC 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRB1	XP_016869180.1	None
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801
		ADAM_CR_2	434..502	CDD:375321	13/63 (21%)
		TSP_1	<699..751	CDD:387593	19/55 (35%)
		TSP1	791..829	CDD:214559	17/46 (37%)
		TSP1	836..881	CDD:214559	20/49 (41%)
		TSP1	896..940	CDD:214559	18/48 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810