DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRB1 and lat-2

DIOPT Version :9

Sequence 1:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens
Sequence 2:	NP_001040724.1	Gene:	lat-2 / 173771	WormBaseID:	WBGene00002252	Length:	1338	Species:	Caenorhabditis elegans

Alignment Length:	1344	Identity:	279/1344 - (20%)
Similarity:	461/1344 - (34%)	Gaps:	382/1344 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   308 QCNREAC--GPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQT-----GDPAAEEWSPWSV 365
            ||   :|  |..|:| ..:||..:..|..:...|....||..|..||     ....|:|
Worm   206 QC---SCPNGYGGQT-CETQSTTNQQASTQRTCGSNDFQFSCPNDQTITVDFASFGAQE------ 260

Human   366 CSSTCGEGWQTRTRFCVS-SSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGF 429
             ||.|.:..|:|.:.|.: :|..|..:.       |.....|.:
Worm   261 -SSMCNQASQSREQTCSNVNSLQTVINA-------CQGLQSCEI--------------------- 296

Human   430 RDRTRTCRPPQFGGNPCEGPEKQ---TKF-CNIA--------------LCPGRAVDGNWNEWSSW 476
            |:.|.|     |...||..|::|   |:. |..|              .|....::.|..:..:.
Worm   297 RNLTST-----FSNTPCPVPQEQYLETRMRCETAQQPSCLSGLIQFDSRCYSMTIETNEKKQRTM 356

Human   477 SACSASCSQG------------RQQRTRECNGPSYGGAECQGHWVET-RDCFL----------QQ 518
            ......|||.            .||..::.|..:   .:....|:.| .:|.|          .|
Worm   357 EDAQTYCSQSGGSIITSPPDALLQQIVQKVNAET---KKTVNFWIGTPNNCQLLMVTGSSTSYSQ 418

Human   519 CPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQ--------CGTQRCP 575
            ||....       .:.:|.|....|....|.:.|     ....|.|...|        .|.|...
Worm   419 CPSSPS-------STANVICSTVPQSTASVSARP-----TQSAPVDPVSQTMARREVYTGVQPPS 471

Human   576 EPHEI-----CDEDNFGAVIWKETPAGEVAAVRC--PRNATGLILRRCELDEEGIAYWEPPTYIR 633
            .|..|     |.::....:.:::|.|..:....|  |:|..|.:.|.|...   .|.||.|....
Worm   472 VPDSINKPRYCKKEKKDGITYEQTRACMLHEQPCPDPQNVEGTVTRYCNCQ---TAKWETPDTTN 533

Human   634 CVSIDYRNIQMMTREHLAKAQRGL----PGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMT 694
            |           |...:|:.:..:    |.|.:|..:...::.:.:.|.:.||:..|:.:..:|.
Worm   534 C-----------THRWVAEMETAIKDNQPVEDISSTVNRQLKSTIERTLFGGDITGTVRLSNDML 587

Human   695 EIFRRAY-----YSPTPGDVQNFVQIL----SNLLAEENRDKWEE--AQLAGPNAKELFRLVEDF 748
            .:.|..:     .:......:||.:.|    ..||:......|::  :.:...:|.:|..::|..
Worm   588 SLARNQFSVLNDRNLRENKARNFTENLGGSGDQLLSPVAATVWDQLSSTIRIQHASKLMSVLEQS 652

Human   749 VDVIGFRMKDLRDAYQVTDNLVLSIHK-------LPASGATDISFPMKGWR--ATGDWAKVPEDR 804
            |.::|..|.|.:...|.. |..:.:.:       ..|:.:.::...|...|  |....|..||..
Worm   653 VLLLGDYMTDQKLNLQYI-NWAMEVERSEPEVQTFGAAASPNVQDDMGMMRVMAAAPPAPQPETN 716

Human   805 VTV--------------SKSVFSTGLTEA--------------DEASVFVVGTV-LYRN------ 834
            .|:              |.|:.|:..:..              |:..|.:..|. |.||
Worm   717 TTIMFPSLKLSPTITLPSASLLSSLASPTPVAGGGPSILSSFQDDTPVGMASTPNLNRNPVKLGY 781

Human   835 -----LGSFLALQRNTTVLNSKVISVTVKPPPRSLRTPLE----IEFAHM-YNGTTNQTCILWDE 889
                 .|..|....:.|::||:||..:::...:|:..|::    ..|.|: ..|.:|..|:.||.
Worm   782 YAFAGFGQLLNNNNDHTLINSQVIGASIQNATQSVTLPVDHPVTFTFQHLTTKGVSNPRCVYWDL 846

Human   890 TDVPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPS---VTL 951
            .:          ..||..||..:...:..::|.|..|::||||..:|.........|.|   |..
Worm   847 ME----------SKWSTLGCTLIATSSNSSQCSCTHLTSFAILMDISGQVGRLSGGLASALDVVS 901

Human   952 IVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAA 1016
            .:||.:|.:.|.:.|.:: :.:|.:::.|:.|..|.||.::.:..:.:||..:|.|:..|.:||.
Worm   902 TIGCAISIVCLALSVCVF-TFFRNLQNVRNSIHRNLCLCLLIAELVFVIGMDRTGNRTGCGVVAI 965

Human  1017 FLHFFFLSSFCWVLTEAWQSYM---AVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYS 1078
            .||:||||||||:|.|.:|.||   .|....|.|:......|  :|.||:|||||.|. |.:.|.
Worm   966 LLHYFFLSSFCWMLLEGYQLYMMLIQVFEPNRTRIFLYYLFC--YGTPAVVVAISAGI-KWEDYG 1027

Human  1079 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGQPSPHPLGRA 1143
            |.:|||:......::|||.|...::..|::..::                              |
Worm  1028 TDSYCWIDTSTPTIWAFVAPIIVIIAANIIFLLI------------------------------A 1062

Human  1144 LKCAECGVLSAADATSDATSNAMASLWSSCVVLPLLALTWMSAVL-AVTDRRSALFQILFAVFDS 1207
            ||.    |||............:..|..|..:|.||.:||:...| ||.......|..:|.:.:.
Worm  1063 LKV----VLSVQSRDRTKWGRIIGWLKGSATLLCLLGITWIFGFLTAVKGGTGTAFAWIFTILNC 1123

Human  1208 LEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSGPEA 1272
            .:|..|.::|.:|..:|:                          |.::......:.....:...|
Worm  1124 TQGIFIFVLHVVLNEKVR--------------------------ASIVRWLRTGICCLPETSSAA 1162

Human  1273 VTGSGFLSCGE-------ANGPCSLWSFRYLKSTFSRDSPGRGAGTAPVLNKDIAACRTATITGT 1330
            .....|||..:       .||       ....||.|.|            :|:.........|..
Worm  1163 YNSRSFLSSRQRILNMIKVNG-------HSYPSTASTD------------DKEKQLTPITKTTDW 1208

Human  1331 LKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKS 1395
            |.|  ||.::.:.:     |.:|||:|...:...:|               |.:...:.|:.|
Worm  1209 LSR--LPNQDSVSI-----PESNFNNLNGTLENSNL---------------NSAEIKEEDEIP-- 1249

Human  1396 SFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPK--PKEEPKYSIHIDQMPQTRLIHL 1458
                          ||.|              ..|..|.|.  ...|.:...|....|:...|..
Worm  1250 --------------ELRR--------------RVTVDLNPMIVSNNEIERMSHASSDPRGSQIIE 1286

Human  1459 STAPEASLPARSPP----SRQPPSG----------GPPEAPPAQ 1488
            .||.|...|.:...    ::|...|          .|||:|.::
Worm  1287 VTAVEKKAPVKRIKFPLGAKQSERGSQHRTKAKVIAPPESPVSE 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRB1	XP_016869180.1	None
lat-2	NP_001040724.1	CLECT	52..193	CDD:214480
		Gal_Lectin	242..322	CDD:280328	24/119 (20%)
		CLECT	330..>399	CDD:295302	9/71 (13%)
		HormR	479..542	CDD:214468	16/76 (21%)
		GAIN	556..>660	CDD:293098	18/103 (17%)
		GPS	837..884	CDD:197639	15/56 (27%)
		7tm_4	894..1129	CDD:304433	78/272 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010