DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRB1 and Adgrb1

DIOPT Version :9

Sequence 1:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens
Sequence 2:	XP_006520332.1	Gene:	Adgrb1 / 107831	MGIID:	1933736	Length:	1620	Species:	Mus musculus

Alignment Length:	1663	Identity:	1519/1663 - (91%)
Similarity:	1554/1663 - (93%)	Gaps:	43/1663 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANA 65
            ||||||||||:|||||||||||||||.||||:|||.|||.|.|.|||||||||||||||||||||
Mouse     1 MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAVFPANA 65

Human    66 SRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPS 130
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.|
Mouse    66 SRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDSS 130

Human   131 APLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDA 195
            |||||||||||||||:||||||...|.|:...|..:||||||||||||||||.||||||||||||
Mouse   131 APLAFLQASKQFLQMQRQQPPQDGDLGPQGEFPSSSDDFSVEYLVVGNRNPSHAACQMLCRWLDA 195

Human   196 CLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGA 260
            |||||||||||||||||||||||:.|.||:.||.|||||||||.||||||||||||||||||||:
Mouse   196 CLAGSRSSHPCGIMQTPCACLGGDVGDPASSPLVPRGDVCLRDGVAGGPENCLTSLTQDRGGHGS 260

Human   261 TGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQ 325
            .|||||||||||||||||||||||||||||..|||||||||||||||.|||:||||.||:|||||
Mouse   261 AGGWKLWSLWGECTRDCGGGLQTRTRTCLPTLGVEGGGCEGVLEEGRLCNRKACGPTGRSSSRSQ 325

Human   326 SLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQC 390
            ||||||||||||.||||||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse   326 SLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQC 390

Human   391 SGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKF 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 SGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKF 455

Human   456 CNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 520
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse   456 CNIALCPGRAVDGNWNEWSSWSTCSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 520

Human   521 VDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDN 585
            |||||||||||||||||||.||||||||||||||||||||||||||||||.||||||||||||||
Mouse   521 VDGKWQAWASWGSCSVTCGGGSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDN 585

Human   586 FGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHL 650
            ||||:||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||
Mouse   586 FGAVVWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHL 650

Human   651 AKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQI 715
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 AKAQRGLPGEGVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQI 715

Human   716 LSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG 780
            :|||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 ISNLLAEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG 780

Human   781 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNT 845
            ||||||||||||||||||||||||||||||||||||.|||::|||||||||||||||||||||||
Mouse   781 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLALQRNT 845

Human   846 TVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCR 910
            |||||||||||||||||||.||||||||||||||||||||||||||.||||||||||||||||||
Mouse   846 TVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPSSSAPPQLGPWSWRGCR 910

Human   911 TVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRY 975
            |||||||||||||||||||||||||||||.|:|.|:|||||||||||||||||||||||||||||
Mouse   911 TVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTVPSVTLIVGCGVSSLTLLMLVIIYVSVWRY 975

Human   976 IRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAV 1040
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   976 IRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAV 1040

Human  1041 TGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLV 1105
            ||.||:||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1041 TGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLV 1105

Human  1106 NMVIGILVFNKLVSKDGITDKKLKERAGQPSPHPLGRALKCAECGVLSAADATSDATSNAMASLW 1170
            |||||||||||||||||||||||||||||....||||||.||||||||||:|.||||||||||||
Mouse  1106 NMVIGILVFNKLVSKDGITDKKLKERAGQLPVPPLGRALTCAECGVLSAAEANSDATSNAMASLW 1170

Human  1171 SSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDR 1235
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1171 SSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDR 1235

Human  1236 QEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSGPEAVTGSGFLSCGEANGPCSLWSFRYLKSTF 1300
            |||||||||||||||||||||||||||||||||| |.:|
Mouse  1236 QEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSG-ERLT-------------------------- 1273

Human  1301 SRDSPGRGAGTAPVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLH 1365
                         |||||||||||||||||.||||||||||:||  |||||..||||||||||||
Mouse  1274 -------------VLNKDIAACRTATITGTFKRPSLPEEEKMKL--AKGPPPTFNSLPANVSKLH 1323

Human  1366 LHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTAT 1430
            |||||||||||||||||||||||:||||||||:||||||||||||||||||||||||||||||||
Mouse  1324 LHGSPRYPGGPLPDFPNHSLTLKKDKAPKSSFIGDGDIFKKLDSELSRAQEKALDTSYVILPTAT 1388

Human  1431 ATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPP 1495
            |||||||||||||||:|||||||||||||.||:||.|.||||:|:||.|.|||.||.||||||||
Mouse  1389 ATLRPKPKEEPKYSINIDQMPQTRLIHLSMAPDASFPTRSPPAREPPGGAPPEVPPVQPPPPPPP 1453

Human  1496 PPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDF 1560
            ||||||||:||||.||||||||||.||||||||||:|...|||||||||||||||||||||||||
Mouse  1454 PPPPPQQPIPPPPTLEPAPPSLGDTGEPAAHPGPSSGAGAKNENVATLSVSSLERRKSRYAELDF 1518

Human  1561 EKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKQPEKQQTPNKRPWESLRKAHGTPTWVKK 1625
            |||||||||||||||||||||||||||:|||.|.||| ||||||||||.||||||.||||.||||
Mouse  1519 EKIMHTRKRHQDMFQDLNRKLQHAAEKEKEVPGADSK-PEKQQTPNKRAWESLRKPHGTPAWVKK 1582

Human  1626 ELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV 1663
            |||||.||||||||||||::||||||||||||||||||
Mouse  1583 ELEPLPPSPLELRSVEWEKAGATIPLVGQDIIDLQTEV 1620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRB1	XP_016869180.1	None
Adgrb1	XP_006520332.1	TSP1	264..314	CDD:214559	45/49 (92%)
		TSP1	359..407	CDD:214559	47/47 (100%)
		TSP1	412..462	CDD:214559	49/49 (100%)
		TSP1	470..520	CDD:214559	48/49 (98%)
		TSP1	525..575	CDD:214559	47/49 (96%)
		HormR	577..643	CDD:214468	63/65 (97%)
		GAIN	661..859	CDD:374574	191/197 (97%)
		GPS	880..938	CDD:197639	56/57 (98%)
		7tmB2_BAI_Adhesion_VII	945..1234	CDD:320379	277/288 (96%)
		TM helix 1	947..971	CDD:320379	23/23 (100%)
		TM helix 2	981..1002	CDD:320379	20/20 (100%)
		TM helix 3	1012..1034	CDD:320379	21/21 (100%)
		TM helix 4	1052..1068	CDD:320379	15/15 (100%)
		TM helix 5	1088..1111	CDD:320379	22/22 (100%)
		TM helix 6	1166..1191	CDD:320379	24/24 (100%)
		TM helix 7	1196..1221	CDD:320379	24/24 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83956482
Domainoid	1	1.000	766	1.000	Domainoid score	I3134
eggNOG	1	0.900	-	-		E1_KOG3538
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1287
Inparanoid	1	1.050	3102	1.000	Inparanoid score	I562
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41304
OrthoDB	1	1.010	-	-		D11632at32523
OrthoFinder	1	1.000	-	-		FOG0010992
OrthoInspector	1	1.000	-	-		oto123669
orthoMCL	1	0.900	-	-		OOG6_105378
Panther	1	1.100	-	-	LDO	PTHR12011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9921
SonicParanoid	1	1.000	-	-		X8565
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300